BMS 582949

Product Name: BMS 582949
CAS No.: 623152-17-0
Chemical Name: BMS 582949
Synonyms: CS-2900;PS540446;BMS 582949;BMS582949(HCl);BMS 582949; BMS582949;BMS582949, 10 mM in DMSO;4-[5-(cyclopropylcarbamoyl)-2-methylanilino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide;4-[[5-[(Cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide;Pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propyl-
CBNumber: CB22627609
Molecular Formula: C22H26N6O2
Formula Weight: 406.48
MOL File: 623152-17-0.mol

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BMS 582949 Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: A crystalline solid
InChIKey: GDTQLZHHDRRBEB-UHFFFAOYSA-N
SMILES: N12C=C(C(NCCC)=O)C(C)=C1C(NC1=CC(C(NC3CC3)=O)=CC=C1C)=NC=N2

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H360May damage fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P281Use personal protective equipment as required.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22892
Product name: BMS 582949
Purity: ≥98%
Packaging: 1mg
Price: $77
Updated: 2024/03/01

Cayman Chemical

Product number: 22892
Product name: BMS 582949
Purity: ≥98%
Packaging: 5mg
Price: $340
Updated: 2024/03/01

Cayman Chemical

Product number: 22892
Product name: BMS 582949
Purity: ≥98%
Packaging: 25mg
Price: $1036
Updated: 2024/03/01

AK Scientific

Product number: 3947BB
Product name: Bms-582949
Packaging: 25mg
Price: $1251
Updated: 2021/12/16

Axon Medchem

Product number: Axon2856
Product name: BMS582949
Purity: 98%
Packaging: 25mg
Price: $599.5
Updated: 2021/12/16

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BMS 582949 Chemical Properties,Usage,Production

Uses

BMS-582949 (compound 7k) is an orally active and highly selective p38α MAP kinase inhibitor, with IC50 values of 13 nM for p38α, and 50 nM for cellular TNFα. BMS-582949 can be used for research on rheumatoid arthritis[1].

Biological Activity

bms-582949 is a p38 mapk inhibitorp38r map kinase plays a key role in regulating the biosynthesis of various inflammatory cytokines, such as tumor necrosis factor alpha and interleukin-1β. thus, p38r inhibitors are considered as a promising therapy for inflammatory disease treatment.

in vitro

bms-582949 was found to be 450-fold selective over jnk2, a map kinase involved in inflammation, and 190-fold selective against raf. moreover, the binding mode of bms-582949 with p38r was further demonstrated by x-ray crystallographic analyses [1].

in vivo

in a pseudoestablished rat adjuvant arthritis model, bms-582949 at doses of 10 and 100 mg/kg was found to display dose-dependent reduction in paw swelling with qd dosing. in addition, with bid dosing at doses of 1 and 5 mg/kg, bms-582949 showed improved efficacy, resulting in great reduction in paw swelling. moreover, the statistically significant reduction in paw swelling was also observed with the treatment of bms-582949 at doses as low as 0.3 mg/kg bid [1].

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 13 nM

Target	Value
p38 MAPK (Cell-free assay)

IC 50

13 nm

References

[1]. liu c, et al. discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl- n-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (bms-582949), a clinical p38α map kinase inhibitor for the treatment of inflammatory diseases. j med chem. 2010 sep 23;53(18):6629-39.
[2]. emami h, et al. the effect of bms-582949, a p38 mitogen-activated protein kinase (p38 mapk) inhibitor on arterial inflammation: a multicenter fdg-pet trial. atherosclerosis. 2015 jun;240(2):490-6.

BMS 582949 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS 582949 Suppliers

China 71 United States 10 Global 81

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623152-17-0, BMS 582949Related Search:

BMS 582949

BMS582949(HCl)

4-[[5-[(Cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide

4-[5-(cyclopropylcarbamoyl)-2-methylanilino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide

CS-2900

BMS 582949; BMS582949

PS540446

Pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propyl-

BMS582949, 10 mM in DMSO

623152-17-0