MTEP
- Product Name
- MTEP
- CAS No.
- 1186195-60-7
- Chemical Name
- MTEP
- Synonyms
- MTEP HCl;3-((2-Methyl-1;3-thiazol-4-yl)ethyn-yl)pyridine hydrochloride;3-[2-(2-Methyl-4-thiazolyl)ethynyl]pyridine hydrochloride (1:1);3-((2-METHYL-1;3-THIAZOL-4-YL)ETHYN-YL)PYRIDINE HYDROCHLORIDE;MTEP;Metabotropic glutamate receptors,mGluR,inhibit,Inhibitor,MTEP hydrochloride;3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine, 3-[(2-Methyl-4-thiazolyl)ethynyl]pyridine
- CBNumber
- CB22628565
- Molecular Formula
- C11H9ClN2S
- Formula Weight
- 236.72056
- MOL File
- 1186195-60-7.mol
MTEP Property
- Melting point:
- 154-156℃ (isopropanol )
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- crystalline solid
- color
- Light cream
N-Bromosuccinimide Price
- Product number
- 14961
- Product name
- MTEP (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 14961
- Product name
- MTEP (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 14961
- Product name
- MTEP (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $112
- Updated
- 2024/03/01
- Product number
- 14961
- Product name
- MTEP (hydrochloride)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $475
- Updated
- 2024/03/01
- Product number
- M759900
- Product name
- MTEPHydrochloride
- Packaging
- 1mg
- Price
- $50
- Updated
- 2021/12/16
MTEP Chemical Properties,Usage,Production
Description
Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-
Uses
MTEP Hydrochloride is a potent mGlu5 receptor antagonist, acting as a negative allosteric modulator.
in vitro
like mpep, mtep showed a nanomolar affinity for mglur5, but seemed to be superior to mpep in term of specificity. mtep did not influence mglur2, mglur7, nmda, ampa or kainate receptors, while inhibited maoa at a concentration three times higher than mpep. moreover, recent study indicated that mtep was five times stronger that mpep as an anxiolytic compound [1].
in vivo
mtep with doses between 0.5 and 3 mg/kg was found to decrease the haloperidol-induced muscle rigidity, which was measured as an increased muscle resistance of the rat hind leg. the longest and strongest effect was observed with the dose of 1 mg/kg. mtep was also found to reduce the haloperidol-induced increase in electromyographic activity recorded in the tibialis anterior and gastrocnemius muscles. 3 and 5 mg/kg of mtep could inhibit the haloperidol- induced catalepsy [1].
IC 50
5 nm
storage
+4°C (desiccate)
References
[1] ossowska k,konieczny j,wolfarth s,pilc a. mtep, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mglur5), produces antiparkinsonian-like effects in rats. neuropharmacology.2005 sep;49(4):447-55.
MTEP Preparation Products And Raw materials
Raw materials
Preparation Products
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