Iohexol

ChemicalBook > CAS DataBase List > Iohexol

Non-ionic contrast agent Pharmacological effects Clinical application Intravascular applications Dosage and Usage Medicine interactions Adverse effects Precautions Uses

Product Name: Iohexol
CAS No.: 66108-95-0
Chemical Name: Iohexol
Synonyms: Lohexol;NYCODENZ;omnipaque;Iohexal;iohexole;Histodenz;5-(n-dhp-acetamido)-2,4,6-triiodo-n,n’-bis-dhp-isophthalami;5-[Acetyl(2,3-dihydroxypropyl)amino]-N,Nbis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide;5-[acetyl(2,3-dihydroxypropyl)amino]-1-N,3-N-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide;Iohexo
CBNumber: CB2262877
Molecular Formula: C19H26I3N3O9
Formula Weight: 821.14
MOL File: 66108-95-0.mol

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Iohexol Property

Melting point:: 254-2560C
Boiling point:: 891.5±65.0 °C(Predicted)
Density: 1.078 g/mL±0.002 g/mL at 25 °C(lit.)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Very soluble in water, freely soluble in methanol, practically insoluble in methylene chloride.
pka: 11.35±0.46(Predicted)
color: White
Merck: 14,5052
BRN: 2406632
Stability:: Hygroscopic
InChIKey: NTHXOOBQLCIOLC-UHFFFAOYSA-N
LogP: -0.5
CAS DataBase Reference: 66108-95-0(CAS DataBase Reference)
EPA Substance Registry System: 1,3-Benzenedicarboxamide, 5-[acetyl(2,3-dihydroxypropyl)amino]-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo- (66108-95-0)

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Safety

Safety Statements: 22-24/25
WGK Germany: 1
RTECS: CZ2205000
HS Code: 2924296000
Toxicity: LD50 in male, female rats, mice (g Iodine/kg): 15.0, 12.3, 24.3, 25.1 i.v. (Salvesen)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 74147
Product name: Iohexol
Purity: analytical standard
Packaging: 50mg
Price: $114
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1344600
Product name: Iohexol
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 550MG
Price: $581
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1344600
Product name: Iohexol
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $445
Updated: 2022/05/15

TCI Chemical

Product number: I0903
Product name: Iohexol (mixture of isomers)
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $39
Updated: 2024/03/01

TCI Chemical

Product number: I0903
Product name: Iohexol (mixture of isomers)
Purity: >98.0%(HPLC)(N)
Packaging: 25g
Price: $117
Updated: 2024/03/01

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Iohexol Chemical Properties,Usage,Production

Non-ionic contrast agent

Iohexol is a non-ionic contrast agent with its pure product appearing as white or light gray powder and having hygroscopicity. In the early 80s of last century, it has been successfully developed by the Nycomed Company (Norwegian) and has first entered into market in 1982 in Norway and Sweden. In 1985, it has obtained the approval of the US Food and Drug Administration (FDA) for entering into US market; in the early 90s, Schering AG and Japan's first pharmaceutical Co., Ltd. were respectively subject to transferee production with product sales in Europe and the Asia-Pacific countries.
The six hydroxyl groups in its molecules are evenly distributed around the benzene ring, effective shielding the lipophilic iodobenzene ring, making it have high hydrophilic, low viscosity, low permeability than ordinary ion-type contrast agent and low toxicity against the nerve system, etc. It is the raw material for the production of water-soluble, non-ionic X-CT contrast agent in pharmaceutical factory. Iohexol is also currently one of the best contrast agents. The developed countries have completely used it to replace ionography agent. It is suitable for myelography, cardiovascular, arteriovenous, lymphatic system, urography and enhanced CT scan. The general dosage is as follows: decision regarding spinal canal imaging is based on the location; lumbar thoracic 24% solution: 8~12ml, neck 24% solution: 10~15ml, CT scan Cisternography 8~12ml.

Pharmacological effects

Iohexol contrast agent belongs to non-ionic water-soluble contrast agent with a similar osmotic pressure with plasma as well as moderate viscosity. It is easily for injection. Clinical angiography and urography have proved less toxic than ionic contrast agents, and can be safely used for myelography. The reason is that the non-ionic contrast agent has weak stimulation on the mast cell with less histamine release and less likely to cause allergic reactions. This product is weak vasodilator, not easy to cause hypotension; it causes very small injury on vascular endothelium, difficult to form thrombosis; small effect on heart and kidney function. It has a lower toxicity than amikacin. This product almost does not penetrate the cell membrane. After intravenous injection, it is mainly distributed in the interstitial cavity without being absorbed by organ and tissue. It is not metabolized by the body and is released mostly with the urine in the prototype form. PBP is smaller than 20%.
Non-ionic intravascular contrast agents: such as iobitridol, ioversol, iodohexol, iopamidol, iopromide and iodixanol.

Clinical application

It can be used for angiography, urography, cerebral angiography, peripheral and various kinds of arterial angiography, venography, digital subtraction and CT enhanced scan. Myelography and the use of subarachnoid injection for brain pool CT scan. It can also be applied to various kinds of body cavity examinations.
Subarachnoid space application
①It should be done of iodine allergy test before the application. Patients of positive result should be disabled. Patients of a history of epilepsy should be disabled.
②Patients having a history of allergies or being suspected allergic to this product, but must be subject to the angiography of this product can choose to apply adrenal cortex hormones and antihistamines before the contrast to prevent. But the spinal cord should be disabled of applying adrenal corticosteroid drugs.
③Patients of local or systemic bacterial infection should not carry out lumbar puncture, of course, can’t use this product for angiography.
④If necessary, it can be given of sedation agents such as diazepam before surgery. Upon severe pain, it can be administrated of analgesics.
⑤Good body fluid condition can reduce the incidence of adverse reactions, therefore it should be prevented of dehydration of patients.
⑥After angiography, allow the patients to sit in bed. The head should be elevated for at least 6 hours. The patient should maintain the supine position for 24 hours without self-move or bending down to prevent the residual contrast agent from flowing into the brain and reduce the leakage of cerebrospinal fluid.
⑦If the patients get nausea, vomiting, it should be applied of intravenous fluids to replace the fluid food; if necessary, it should be given of antiemetic.
⑧Upon myelography failure, it is not appropriate for immediate repeated angiography.
⑨Upon seizures, it should be immediately applied of intravenous injection of 10mg diazepam. To prevent recurrence of epilepsy, it can be applied of intramuscular injection of 0.2 g phenobarbital sodium at 20 to 30 minutes after the stopping of pathogenesis.
⑩The relative density of iohexol injection should be higher than that of cerebrospinal fluid.

Intravascular applications

①Before use, it should be applied of allergy testing. Positive patients should be disabled.
②Patients having a history of allergy, being allergic to iodine, of asthma should be disabled or used with caution.
③Patients of severe liver and kidney dysfunction, severe thyroid disease, bone marrow leukemia should be used with caution; These patients should be disabled upon dehydration. Patients of diabetes having a serum creatinine concentration of more than 0.5mmol /L should be disabled.
④pregnant women should be used with caution. Under conditions that it must be applied, it should be used of the lowest dose.
⑤This product can interfere with thyroid function tests, so that the ability of thyroid tissue binding to iodine will be reduced, and it should be taken of several days or even two weeks for fully recover.
⑥contrast agent should not be mixed with other drugs for compatibility, instead should be used of a dedicated syringe.

Dosage and Usage

Intrathecal injection: Dose should be according to the check project and the usage technical decisions. It can be referred to the following table.

▼

▲

Application items

Concentration (mg/ml)

Usage amount (ml/per time)

Waist, thoracic
angiography

180
240

0~15
8~12

Cervical angiography
CT scan Cisternography

240
180
240

10~12
5~15
4~12

Myelography for children

<2 years old
2～6 years old
>6 years old

180
180
180

2~6
4~8
6~12

It can be used for cardiovascular, arterial intravenous and urinary tract radiography. The iodine concentration and dosage used should be generally the same as other angiographic contrast agents currently used.

Medicine interactions

1, Patients subjecting to metformin treatment, if subjecting to simultaneous injection of iohexol contrast agent, may get lactic acidosis and acute renal failure.
2, Simultaneous administration of tricyclic antidepressants or monoamine oxidase inhibitors during the intrathecal injection of the drug can reduce the threshold of seizures, and lead to seizures.
3. Patients treated with interleukin-2 within 2 weeks had an increased risk of delayed response (cold-like symptoms and skin reactions).
4, Ⅲ antiarrhythmic drugs such as amiodarone, in the recommended dose, can extend the QT interval. The effect of prolonging the QT interval when combined with this product has additive effect.
This information was edited by Chemicalbook (2015-08-03).

Adverse effects

1. Adverse effects after application in subarachnoid space are generally the same as that of receiving the lumbar puncture, but are mostly mild. The incidence of headache is less than that of using meglumine. Severe headache lasting several days may be intermittent. Other may have nausea, vomiting, dizziness, neck back pain, limb pain and paresthesia. EEG showed no clear short wave.
2. Adverse effects after intravascular administration were significantly lower than those of other ionic contrast agents in frequency and severity, and adverse reactions were similar to that of meglumine. A small number of patients have mild reactions, such as warm feeling, red, nausea, vomiting, mild chest pain, skin itching, urticaria, numbness and lower limbs.

Precautions

1, Patients with allergic history to iodine and allergic constitution should take with caution.
2, Patients of liver and kidney dysfunction, heart and circulatory system dysfunction, physical weakness, cerebral arteriosclerosis, diabetes, goiter and leukemia should take with caution.
3, Patients of severe hyperthyroidism should be disabled.
4, generally it should be prepared well of acute allergic reactions rescue.
Chemical properties
It appears as white or light gray powder with hygroscopicity.

Uses

It is the raw material for the production of water-soluble, non-ionic X-CT contrast agent in pharmaceutical factory. The trade name of this contrast agent is Omnipaque. This contrast agent is usually injected into the vein before CT angiography to be used for angiography, urinary system, spinal cord and joint, lymphatic system angiography, with advantages of low contrast density, low toxicity and good tolerance type. Iohexol is also currently one of the best contrast agents. The developed countries have completely used it to replace ionography agent. It is also a diagnostic drug.
It can be used as non-ionic X-CT contrast agent.

Chemical Properties

White Solid

Uses

antibacterial

Uses

Imaging agent.

Definition

ChEBI: A benzenedicarboxamide compound having N-(2,3-dihydroxypropyl)carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an N-(2,3-dihydroxypropyl)acetamido group at the 5-position.

brand name

Omnipaque (GE Healthcare).

General Description

Iohexol is a low-osmolar, nonionicmonomer with 46% iodine content. Iohexol is one ofthe few iodinated contrast agents indicated for intrathecaluse (myelography). Only selected concentrations of theproduct have this indication. Besides myelography, iohexolfinds widespread use in excretory urography, angiography,and CT procedures. Specific concentrations may have additionalindications in adults and/or children for arthrography,hysterosalpingography, endoscopic retrograde pancreatography,cholangiopancreatography, herniography, voidingcystourethrography, oral pass-thru examination of the GItract or CT of the abdomen.

Iohexol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Iohexol manufacturers

Wuhan Boyuan Import & Export Co., LTD

Product: Iohexol CAS NO.66108-95-0 CAS NO.66108-95-0 66108-95-0
Price: US $1.00/G
Min. Order: 100G
Purity: 99.9%
Supply Ability: 50000 tons
Release date: 2018-10-17

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Iohexol 66108-95-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 2000kg/month
Release date: 2021-06-23

Anhui Yisheng Technology Co., LTD

Product: Iohexol 66108-95-0
Price: US $65.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 2000 kg
Release date: 2023-01-11

66108-95-0, IohexolRelated Search:

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win39424

5-[Acetyl(2,3-dihydroxypropyl)amino]-N,Nbis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide

Accudenz

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histodenz solution

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5-(N-2,3-Dihydroxypropylacetamido)-2,4,6-triiodo-N,N-bis-(2,3 dihydroxypropy)isophthaamide

Histodenz

5-[acetyl(2,3-dihydroxypropyl)amino]-1-N,3-N-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide

5-[acetyl(glyceryl)amino]-N,N'-diglyceryl-2,4,6-triiodo-isophthalamide

N1,N3-bis(2,3-dihydroxypropyl)-5-[2,3-dihydroxypropyl(ethanoyl)amino]-2,4,6-triiodo-benzene-1,3-dicarboxamide

Histodenz,5-(N-2,3-Dihydroxypropylacetamido)-2,4,6-triiodo-N,N′-bis(2,3-dihydroxypropyl)isophthalamide, Nycodenz

Iohexol (200 mg)

1-N,3-N-bis[(2S)-2,3-dihydroxypropyl]-5-{N-[(2S)-2,3-dihydroxypropyl]acetaMido}-2,4,6-triiodobenzene-1,3-dicarboxaMide

Iohexol,iohexole,nycodenz,oMnipaque

Iohexol COS

Iohexal

5-[N-(2,3-Dihydroxypropyl)acetamido]-2,4,6-triiodo-N,N′-bis(2,3-dihydroxypropyl)isophthalamide solution

5-(acetyl-(2,3-dihydroxypropyl)amino)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-benzene-1,3-dicarboxamide

5-(acetyl-(2,3-dihydroxypropyl)amino)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide

5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide

bis(2,3

N,N'-bis(2,3-dihydroxypropyl)-5-(2,3-dihydroxypropyl-ethanoyl-amino)-2,4,6-triiodo-benzene-1,3-dicarboxamide

N1,N3-bis(2,3-dihydroxypropyl)-5-(N-(2,3-dihydroxypropyl)acetamido)-2,4,6-triiodoisophthalamide

Iohexol (mixture of isomers)

5-(N-2,3-Dihydroxypropylacetamido)-2,4,6-triiodo-N,N′-bis(2,3-dihydroxypropyl)isophthalamide

Iohexolum

Iodixanol Impurity 1(Iodixanol EP Impurity A)

Iohexol CAS NO.66108-95-0 CAS NO.66108-95-0

Iohexol for peak identification CRS

Iohexol CRS

Iohexol, isomer mixture

Iohexol (mixture of isomers) &gt

1,3-Benzenedicarboxamide, 5-[acetyl(2,3-dihydroxypropyl)amino]-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-

Iohexol (mixture of isomers) [for iTOMEI]

Iohexol for peak identification (Y0000672)Q: What is Iohexol for peak identification (Y0000672) Q: What is the CAS Number of Iohexol for peak identification (Y0000672)