tert-butyl 4-(pyriMidin-5-yl)piperazine-1-carboxylate
- Product Name
- tert-butyl 4-(pyriMidin-5-yl)piperazine-1-carboxylate
- CAS No.
- 634468-96-5
- Chemical Name
- tert-butyl 4-(pyriMidin-5-yl)piperazine-1-carboxylate
- Synonyms
- Nicotinamide Impurity 203;tert-butyl 4-(pyriMidin-5-yl)piperazine-1-carboxylate;1-Piperazinecarboxylic acid, 4-(5-pyrimidinyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB22645090
- Molecular Formula
- C13H20N4O2
- Formula Weight
- 264.32
- MOL File
- 634468-96-5.mol
tert-butyl 4-(pyriMidin-5-yl)piperazine-1-carboxylate Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Light brown to brown Solid
N-Bromosuccinimide Price
- Product number
- Z4977
- Product name
- tert-Butyl4-(pyrimidin-5-yl)piperazine-1-carboxylate
- Packaging
- 5g
- Price
- $444
- Updated
- 2021/12/16
- Product number
- CHM0394198
- Product name
- TERT-BUTYL-4-(PYRIMIDIN-5-YL)PIPERAZINE-1-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.71
- Updated
- 2021/12/16
- Product number
- FB143442
- Product name
- tert-Butyl 4-(pyrimidin-5-yl)piperazine-1-carboxylate
- Packaging
- 5G
- Price
- $656.25
- Updated
- 2021/12/16
- Product number
- A225813
- Product name
- tert-Butyl4-(pyrimidin-5-yl)piperazine-1-carboxylate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $16
- Updated
- 2021/12/16
- Product number
- A225813
- Product name
- tert-Butyl4-(pyrimidin-5-yl)piperazine-1-carboxylate
- Purity
- 98%
- Packaging
- 1g
- Price
- $36
- Updated
- 2021/12/16
tert-butyl 4-(pyriMidin-5-yl)piperazine-1-carboxylate Chemical Properties,Usage,Production
Synthesis
4595-59-9
57260-71-6
634468-96-5
(1) Preparation of tert-butyl 4-(pyrimidin-5-yl)piperazine-1-carboxylate: a 100 mL aubergine flask was charged with 5-bromopyrimidine (3.16 g, 20 mmol), N-BOC-piperazine (3.72 g, 20 mmol), 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP, 2.49 g, 4 mmol), cesium carbonate ( 13.0 g, 40 mmol) and tris(dibenzylideneacetone)dipalladium (Pd2(dba)3, 1.83 g, 2 mmol). Toluene (80 mL) was then added as solvent. The reaction mixture was heated to 90 °C and stirred for 12 h under the protection of nitrogen atmosphere. Upon completion of the reaction, the mixture was filtrated and the filtrate was concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with the eluent ratio of dichloromethane:methanol=50:1, and tert-butyl 4-(pyrimidin-5-yl)piperazine-1-carboxylate (3.1 g, 58.7% yield) was finally obtained.
References
[1] Tetrahedron Letters, 2006, vol. 47, # 15, p. 2549 - 2552
[2] Patent: EP3091008, 2016, A1. Location in patent: Paragraph 0380; 0381
[3] Patent: US2005/176722, 2005, A1. Location in patent: Page/Page column 20
tert-butyl 4-(pyriMidin-5-yl)piperazine-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
tert-butyl 4-(pyriMidin-5-yl)piperazine-1-carboxylate Suppliers
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