JW55
- Product Name
- JW55
- CAS No.
- 664993-53-7
- Chemical Name
- JW55
- Synonyms
- JW55;CS-1095;JW55 ，S6745;JW 55; JW-55;JW 55, >=98%;JW 55, 10 mM in DMSO;Tankyrase1/2 Inhibitor IV, JW55;Tankyrase1/2 Inhibitor IV, JW55 - CAS 664993-53-7 - Calbiochem;N-[4-[[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYLCARBAMOYL]PHENYL]FURAN-2-CARBOXAMIDE;N-(4-((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)MethylcarbaMoyl)phenyl)furan-2-carboxaMide
- CBNumber
- CB22645126
- Molecular Formula
- C25H26N2O5
- Formula Weight
- 434.48
- MOL File
- 664993-53-7.mol
JW55 Property
- Boiling point:
- 572.6±50.0 °C(Predicted)
- Density
- 1.235±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO: soluble15mg/mL, clear
- form
- powder
- pka
- 12.41±0.70(Predicted)
- color
- white to beige
- InChI
- 1S/C25H26N2O5/c1-30-21-10-6-19(7-11-21)25(12-15-31-16-13-25)17-26-23(28)18-4-8-20(9-5-18)27-24(29)22-3-2-14-32-22/h2-11,14H,12-13,15-17H2,1H3,(H,26,28)(H,27,29)
- InChIKey
- ZJZWZIXSGNFWQQ-UHFFFAOYSA-N
- SMILES
- O1C=CC=C1C(NC1=CC=C(C(NCC2(C3=CC=C(OC)C=C3)CCOCC2)=O)C=C1)=O
Safety
- WGK Germany
- 3
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 575547
- Product name
- Tankyrase1/2 Inhibitor IV, JW55
- Packaging
- 25mg
- Price
- $229
- Updated
- 2026/03/19
- Product number
- SML0630
- Product name
- JW55
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $104
- Updated
- 2025/07/31
- Product number
- 16260
- Product name
- JW 55
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 16260
- Product name
- JW 55
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- SML0630
- Product name
- JW55
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $428
- Updated
- 2022/05/15
JW55 Chemical Properties,Usage,Production
Description
JW 55 is an inhibitor of the PARP domain of tankyrases (TNKS) 1 and 2 (IC50s = 1.9 and 0.83 μM, respectively). By inhibiting TNKS1/2, JW 55 stabilizes Axin2 and increases degradation of β-catenin, inhibiting the β-catenin signaling pathway (IC50 = 470 nM). It has been shown to decrease canonical Wnt signaling in SW480 and HCT15 colon carcinoma cell lines and to reduce proliferation of SW480 cells in vitro.
Uses
JW-55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin. JW-55 inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines. JW-55 reduces cell cycle progression and proliferation in SW480 cells in vitro.
Definition
ChEBI: N-[4-[[[4-(4-methoxyphenyl)-4-oxanyl]methylamino]-oxomethyl]phenyl]-2-furancarboxamide is a member of furans and an aromatic amide.
in vivo
JW 55 (100 mg/kg, orally) reduces tumor development in conditional Apc knockout mice. JW55 reduces XWnt8-induced axis duplication inXenopus embryos and Tamoxifen-induced polyposis formation in conditional APC mutant mice[1].
IC 50
TNKS2: 0.83 μM (IC50); TNKS1: 1.9 μM (IC50)
storage
Store at +4°C
References
[1] waaler j, machon o, tumova l, dinh h, korinek v, wilson sr, paulsen je, pedersen nm, eide tj, machonova o, gradl d, voronkov a, von kries jp, krauss s. a novel tankyrase inhibitor decreases canonical wnt signaling in colon carcinoma cells and reduces tumor growth in conditional apc mutant mice. cancer res. 2012;72(11):2822-32.
JW55 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from JW55 manufacturers
- Product
- JW55 664993-53-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98-100%
- Supply Ability
- 1000kg
- Release date
- 2018-08-20