AST-1306

ChemicalBook > CAS DataBase List > AST-1306

Product Name: AST-1306
CAS No.: 1050500-29-2
Chemical Name: AST-1306
Synonyms: AST-6;CS-249;AST-130;AST-1306 (TsOH);AST1306 tosilate;AST-1306 mesylate;AST 1306 tosylate;AST1306; AST 1306;Allitinib tosylate;AST-1306 USP/EP/BP
CBNumber: CB22646572
Molecular Formula: C31H26ClFN4O5S
Formula Weight: 621.0783432
MOL File: 1050500-29-2.mol

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AST-1306 Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29708
Product name: AST-1306 (tosylate)
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 29708
Product name: AST-1306 (tosylate)
Packaging: 25mg
Price: $616
Updated: 2024/03/01

Cayman Chemical

Product number: 29708
Product name: AST-1306 (tosylate)
Packaging: 5mg
Price: $262
Updated: 2024/03/01

Cayman Chemical

Product number: 29708
Product name: AST-1306 (tosylate)
Packaging: 10mg
Price: $412
Updated: 2024/03/01

ChemScene

Product number: CS-1209
Product name: Allitinibtosylate
Purity: 99.23%
Packaging: 5mg
Price: $180
Updated: 2021/12/16

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AST-1306 Chemical Properties,Usage,Production

Uses

Alitinib (AST-1306) is a structural analog of lapatinib, a new quinazoline anti-tumor drug, and a small molecule epidermal growth factor receptor tyrosine kinase inhibitor, which selectively acts on EGFR/ErbB2 /ErbB4 receptor.

Biological Activity

ast-1306 is a selective, irreversible inhibitor of erbb2 and egfr with ic50 values of 0.5nm and 3nm, respectively [1].ast-1306 is designed and synthesized based on the chemical structure of lapatinib. the molecular docking method shows ast-1306 binds to the atp-binding pocket of the kinases and form covalent bind with certain amino acids. ast-1306 can inhibit egfr and erbb2 in a cell-free assay with more than 3000-fold selectivity to other kinases. besides the wild-type egfr, ast-1306 also inhibits egfr mutant t790m/l858r both in a cell-free assay and in hih3t3 cells. the growth of the cells is suppressed by ast-1306 due to the inhibition of the phosphorylation of egfr. it also occurs in some human cancer cells. experiments have proved that ast-1306 notly inhibits the phosphorylation of egfr and erbb2 and subsequently decreases the downstream pathways of these kinases in a549 cells, calu-3 cells and sk-ov-3 cells. moreover, ast-1306 potently inhibits the tumor growth both in erbb2-overexpressing xenograft models and fvb-2/nneu transgenic mouse model [1].

target

ErbB2

References

[1] xie h, lin l, tong l, jiang y, zheng m, chen z, jiang x, zhang x, ren x, qu w, yang y, wan h, chen y, zuo j, jiang h, geng m, ding j. ast1306, a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, exhibits antitumor activity both in vitro and in vivo. plos one. 2011;6(7):e21487.

AST-1306 Preparation Products And Raw materials

Raw materials

Preparation Products

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1050500-29-2, AST-1306Related Search:

Ruxolitinib Cabozantinib Ceritinib (LDK378) Ibrutinib Apatinib Anlotinib Sotrastaurin Y27632 (hydrochloride) Selumetinib Dacomitinib Afatinib AZD-9291

AST-6

N-[4-[[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-2-propenamide 4-methylbenzenesulfonate

AST 1306 (p-Toluenesulfonic acid)

AST-1306 (p-Toluenesulfonic acid)

AST1306 (p-Toluenesulfonic acid)

AST-1306 (TsOH)

AST1306 tosilate

AST 1306 tosylate

AST-1306 mesylate

Allitinib tosylate

2-Propenamide, N-[4-[[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-, 4-methylbenzenesulfonate (1:1)

AST1306; AST 1306

CS-249

AST-130

AST-1306 USP/EP/BP

Allitinib tosylate AST-1306

N-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)acrylamide 4-methylbenzenesulfonate

1050500-29-2

C31H26ClFN4O5S

C24H18ClFN4O2C7H8O3S

Inhibitors

Anti-cancer&immunity