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Necrostatin-5

Product Name
Necrostatin-5
CAS No.
337349-54-9
Chemical Name
Necrostatin-5
Synonyms
Necrostatin-5;Necrostatin-5 (Nec-5);Necrostatin5,Necrostatin 5;Necrostatin-5 >=98% (HPLC), solid;Necrostatin-5, Necroptosis inhibitor;3-p-methoxyphenyl-5,6-tetramethylenothieno[2,3-d]pyrimidin-4-one-2-mercaptoethylcyanide;2-[[3,4,5,6,7,8-Hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]-acetonitrile;2-((3-(4-Methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetonitrile;Acetonitrile, 2-[[3,4,5,6,7,8-hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]-
CBNumber
CB22648778
Molecular Formula
C19H17N3O2S2
Formula Weight
383.49
MOL File
337349-54-9.mol
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Necrostatin-5 Property

Melting point:
212-214℃
storage temp. 
2-8°C
solubility 
DMSO: >10mg/mL
form 
solid
color 
white to off-white
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N0164
Product name
Necrostatin-5
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$79.1
Updated
2025/07/31
Sigma-Aldrich
Product number
N0164
Product name
Necrostatin-5
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$320
Updated
2022/05/15
Cayman Chemical
Product number
10527
Product name
Necrostatin-5
Purity
≥98%
Packaging
5mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
10527
Product name
Necrostatin-5
Purity
≥98%
Packaging
25mg
Price
$216
Updated
2024/03/01
Usbiological
Product number
045074
Product name
Necrostatin-5
Packaging
5mg
Price
$282
Updated
2021/12/16
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Necrostatin-5 Chemical Properties,Usage,Production

Uses

Necrostatin-5 (Nec-5) is a potent necroptosis inhibitor with an EC50 value of 0.24 μM. Necrostatin-5 also is a RIP1 inhibitor. Necrostatin-5 shows cardioprotective effects[1][2][3].

Biological Activity

Necrostatin-5 is an inhibitor of necroptosis (non-apoptotic cell death pathway) by indirect inhibition of RIP1 kinase. Necroptosis is defined as alternative active cell death pathway: Death-Domain Receptor (DRs, e.g. Fas/TNFR) mediated and caspase-inhibitor insensitive with specific morphology (nuclear condensation, organelle swelling, loss of plasma membrane integrity). The necrostatins have been discovered to inhibit this pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved: T-loop dependent inhibition by necrostatin-1; partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5, since necrostatin-5 is a potent inhibitor of immunnoprecipitated RIP1, but does not inhibit recombinant RIP1.

in vivo

Necrostatin-5 (2.46 mg/kg; i.p.) shows cardioprotective effects on the isolated heart model in rats[2].

Animal Model:200-300 g, male Wistar rats[2]
Dosage:2.46 mg/kg
Administration:I.p.; 60 min before experiment
Result:Reduced the infarction zone caused by 30-min global ischemia and 120-min reperfusion.

IC 50

RIPK1; necroptosis: 0.24 μM (EC50)

storage

+4°C

References

[1] Wang K, et al. Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1455-65. DOI:10.1016/j.bmcl.2006.11.056
[2] Dmitriev YV, et al. Study of cardioprotective effects of necroptosis inhibitors on isolated rat heart subjected to global ischemia-reperfusion. Bull Exp Biol Med. 2013 Jun;155(2):245-8. DOI:10.1007/s10517-013-2124-2
[3] González-Juarbe N, et al. Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia. PLoS Pathog. 2015 Dec 11;11(12):e1005337. DOI:10.1371/journal.ppat.1005337

Necrostatin-5 Preparation Products And Raw materials

Raw materials

Preparation Products

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Necrostatin-5 Suppliers

China 64 United Kingdom 1 United States 7 Global 72
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3988
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66
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
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58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
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58
Jinan Jiuli Biotechnology Co. , Ltd.
Tel
15865264761
Email
486064515@qq.com
Country
China
ProdList
4810
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58
Zhengzhou convergence chemical co., LTD
Tel
0371-0371-55153829 18003835034
Email
2853979819@qq.com
Country
China
ProdList
9998
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58

337349-54-9, Necrostatin-5Related Search:

Necrostatin-7 (Nec-7)

  • Necrostatin-5
  • Necrostatin-5 (Nec-5)
  • 2-[[3,4,5,6,7,8-Hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]-acetonitrile
  • 3-p-methoxyphenyl-5,6-tetramethylenothieno[2,3-d]pyrimidin-4-one-2-mercaptoethylcyanide
  • Acetonitrile, 2-[[3,4,5,6,7,8-hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]-
  • Necrostatin-5 >=98% (HPLC), solid
  • Necrostatin5,Necrostatin 5
  • 2-((3-(4-Methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetonitrile
  • Necrostatin-5, Necroptosis inhibitor
  • 337349-54-9