Necrostatin-7 (Nec-7)

Product Name: Necrostatin-7 (Nec-7)
CAS No.: 351062-08-3
Chemical Name: Necrostatin-7 (Nec-7)
Synonyms: Nec-7;Necrostatin-7;Necrostatin-7 (Nec-7);Necrostatin-7 >=98% (HPLC), powder;Necrostatin-7, Necroptosis inhibitor;5-[[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone;5-((3-(4-Fluorophenyl)-1H-pyrazol-4-yl)methylene)-2-imino-3-(thiazol-2-yl)thiazolidin-4-one;4-Thiazolidinone, 5-[[3-(4-fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-;(5Z)-5-[[5-(4-fluorophenyl)-1H-pyrazol-4-yl]methylidene]-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one
CBNumber: CB92677870
Molecular Formula: C16H10FN5OS2
Formula Weight: 371.41
MOL File: 351062-08-3.mol

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Necrostatin-7 (Nec-7) Property

Boiling point:: 613.4±65.0 °C(Predicted)
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >10mg/mL (with warming)
pka: 11.56±0.50(Predicted)
form: powder
color: yellow to tan

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10528
Product name: Necrostatin-7
Purity: ≥98%
Packaging: 5mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 10528
Product name: Necrostatin-7
Purity: ≥98%
Packaging: 25mg
Price: $363
Updated: 2024/03/01

Usbiological

Product number: 045075
Product name: Necrostatin-7
Packaging: 5mg
Price: $316
Updated: 2021/12/16

Usbiological

Product number: N2059-27
Product name: Necrostatin-7
Packaging: 5mg
Price: $356
Updated: 2021/12/16

AK Scientific

Product number: 6241CE
Product name: Necrostatin-7
Packaging: 5mg
Price: $214
Updated: 2021/12/16

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Necrostatin-7 (Nec-7) Chemical Properties,Usage,Production

Uses

Necrotatin-7 (Nec-7) is a potent necroptosis inhibitor with an EC50 of 10.6 μM. Necrotatin-7 does not inhibit recombinant RIP1 kinase[1].

Biological Activity

Necrostatin-7 (Nec-7) is a potent inhibitor of necroptosis, a regulated caspase-independent necrotic cell death pathway, distinct from apoptosis. Nec-7 has a different profile from the other necrostatins as it does not inhibit RIP1 kinase, suggesting the possibility th at it may target an additional as yet unknown regulatory molecule in the pathway.

storage

+4°C

References

[1] Weihong Zheng, et al. Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4932-5. DOI:10.1016/j.bmcl.2008.08.058

Necrostatin-7 (Nec-7) Preparation Products And Raw materials

Raw materials

Preparation Products

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Necrostatin-7 (Nec-7) Suppliers

China 56 United Kingdom 1 United States 7 Global 64

Chengdu HappySyn Pharmaceutical Technology Co., Ltd.

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Country: China
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Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
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Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
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Country: United States
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Energy Chemical

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Bide Pharmatech Ltd.

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TargetMol Chemicals Inc.

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Suzhou Zhixin Biotechnology Co., Ltd.

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351062-08-3, Necrostatin-7 (Nec-7)Related Search:

Necrostatin-5

Nec-7

(5Z)-5-[[5-(4-fluorophenyl)-1H-pyrazol-4-yl]methylidene]-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one

Necrostatin-7 (Nec-7)

5-[[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone

Necrostatin-7

4-Thiazolidinone, 5-[[3-(4-fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-

Necrostatin-7 >=98% (HPLC), powder

5-((3-(4-Fluorophenyl)-1H-pyrazol-4-yl)methylene)-2-imino-3-(thiazol-2-yl)thiazolidin-4-one

Necrostatin-7, Necroptosis inhibitor

351062-08-3

C16H10FN5OS2