ChemicalBook > CAS DataBase List > 6-BROMO-2-METHOXYNICOTINIC ACID

6-BROMO-2-METHOXYNICOTINIC ACID

Product Name
6-BROMO-2-METHOXYNICOTINIC ACID
CAS No.
1060806-62-3
Chemical Name
6-BROMO-2-METHOXYNICOTINIC ACID
Synonyms
6-BROMO-2-METHOXYNICOTINIC ACID;6-bromo-2-methoxy-pyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 6-bromo-2-methoxy-
CBNumber
CB22658478
Molecular Formula
C7H6BrNO3
Formula Weight
232.03
MOL File
1060806-62-3.mol
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6-BROMO-2-METHOXYNICOTINIC ACID Property

Boiling point:
327.0±42.0 °C(Predicted)
Density 
1.713±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
3.13±0.10(Predicted)
Appearance
White to off-white Solid
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B111740
Product name
6-Bromo-2-methoxynicotinicAcid
Packaging
50mg
Price
$240
Updated
2021/12/16
AK Scientific
Product number
1358AA
Product name
6-Bromo-2-methoxynicotinicacid
Packaging
250mg
Price
$265
Updated
2021/12/16
Apolloscientific
Product number
OR314013
Product name
6-Bromo-2-methoxynicotinic acid
Purity
95%
Packaging
250mg
Price
$473
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0367724
Product name
6-BROMO-2-METHOXYNICOTINIC ACID
Purity
95.00%
Packaging
5MG
Price
$502.57
Updated
2021/12/16
Chemenu
Product number
CM176825
Product name
6-Bromo-2-methoxynicotinicacid
Purity
95%
Packaging
1g
Price
$561
Updated
2021/12/16
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6-BROMO-2-METHOXYNICOTINIC ACID Chemical Properties,Usage,Production

Synthesis

40473-07-2

124-38-9

1060806-62-3

General procedure for the synthesis of 6-bromo-2-methoxycarboxylic acid pyridine from 2-bromo-6-methoxypyridine and carbon dioxide: Preparation of 2-methoxy-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-nicotinamide: Step 1: Synthesis of 6-bromo-2-methoxynicotinic acid: A tetrahydrofuran (5 mL) solution of 2,2,6,6-tetramethylpiperidine (0.766 g, 5.32 mmol) was cooled under nitrogen protection to -78°C. A hexane solution of 2.5 M n-butyllithium (2.34 mL, 0.375 g, 5.85 mmol) was slowly added and stirred at -78°C for 30 min. Subsequently, a tetrahydrofuran (5 mL) solution of 2-bromo-6-methoxypyridine (1.00 g, 5.32 mmol) was added dropwise. The reaction mixture was continued to be stirred at -78°C for 1 hour. After that, an excess of dry ice was added to slowly warm the reaction mixture to room temperature for 3 hours. Upon completion of the reaction, water and ethyl acetate were added for layering. The aqueous layer was acidified to pH 4 with hydrochloric acid and then extracted three times with ethyl acetate. The organic layers were combined, washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated to give an off-white solid product (0.530 g, 42.9% yield). 1H NMR (500 MHz, DMSO-d6) δ ppm: 2.52 (2H, br.s.), 3.32 (1H, br.s.), 3.90 (1H, d, J = 2.9 Hz), 3.92 (1H, m), 8.03 (1H, d, J = 7.8 Hz).

References

[1] Patent: WO2010/116282, 2010, A1. Location in patent: Page/Page column 60

6-BROMO-2-METHOXYNICOTINIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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6-BROMO-2-METHOXYNICOTINIC ACID Suppliers

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