4-Difluoromethoxy-3-hydroxybenzaldehyde

Product Name: 4-Difluoromethoxy-3-hydroxybenzaldehyde
CAS No.: 151103-08-1
Chemical Name: 4-Difluoromethoxy-3-hydroxybenzaldehyde
Synonyms: 4-DifL;Roflumilast impurity 19;uoromethoxy-3-hydroxybenzaL;3-Hydroxy-4-diflouromethylbenzaldehyde;4-DIFLUOROMETHOXY-3-HYDROXYBENZALDEHYDE;4-Di?uoromethoxy-3- hydroxybenzaldehyde;3-hydroxy-4-difluoroMethoxy benzaldehyde;4-(Difluoiromethoxy)-3-Hydroxybenzaldehyde;Benzaldehyde,4-(difluoroMethoxy)-3-hydroxy-;4-(Difluoromethoxy)-3-hydroxybenzaldehyde97%
CBNumber: CB2266224
Molecular Formula: C8H6F2O3
Formula Weight: 188.13
MOL File: 151103-08-1.mol

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4-Difluoromethoxy-3-hydroxybenzaldehyde Property

Melting point:: 85-90°C
Boiling point:: 280.6±35.0 °C(Predicted)
Density: 1.395±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 7.85±0.35(Predicted)
color: White
InChI: InChI=1S/C8H6F2O3/c9-8(10)13-7-2-1-5(4-11)3-6(7)12/h1-4,8,12H
InChIKey: ZLIKNROJGXXNJG-UHFFFAOYSA-N
SMILES: C(=O)C1=CC=C(OC(F)F)C(O)=C1
CAS DataBase Reference: 151103-08-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-51-22
Safety Statements: 26-36/37/39
WGK Germany: 3
Hazard Note: Irritant
HS Code: 2913000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D4505
Product name: 4-(Difluoromethoxy)-3-hydroxybenzaldehyde
Packaging: 5G
Price: $199
Updated: 2025/07/31

TRC

Product number: D446005
Product name: 4-(Difluoromethoxy)-3-hydroxybenzaldehyde
Packaging: 25g
Price: $280
Updated: 2021/12/16

TRC

Product number: D446005
Product name: 4-(Difluoromethoxy)-3-hydroxybenzaldehyde
Packaging: 1g
Price: $55
Updated: 2021/12/16

TRC

Product number: D446005
Product name: 4-(Difluoromethoxy)-3-hydroxybenzaldehyde
Packaging: 10g
Price: $130
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD21875
Product name: 4-(Difluoromethoxy)-3-hydroxybenzaldehyde
Packaging: 5G
Price: $95
Updated: 2021/12/16

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4-Difluoromethoxy-3-hydroxybenzaldehyde Chemical Properties,Usage,Production

Description

4-Difluoromethoxy-3-hydroxybenzaldehyde is an organofluorine compound, mainly used as an intermediate in organic synthesis. It is used in the synthesis of the impurity N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-3-hydroxybenzamide isolated from roflumilast crude^[1].

Chemical Properties

4-Difluoromethoxy-3-hydroxybenzaldehyde is white powder

Uses

4-Difluoromethoxy-3-hydroxybenzaldehyde is a phenyl alkyl ketone derivative used in the preparation of phosphodiesterase-4 (PDE4) inhibitors.

Synthesis

1514-87-0

139-85-5

151103-08-1

Example 10 Preparation of 4-difluoromethoxy-3-hydroxybenzaldehyde: 3,4-dihydroxybenzaldehyde (0.50 g, 3.62 mmol, Aldrich), methyl 2-chloro-2,2-difluoroacetate (0.52 g, 3.62 mmol, Aldrich), and potassium carbonate (0.50 g, 3.62 mmol) were placed in argon- protected DMF ( 5.0 mL). The reaction mixture was stirred at 60°C to 65°C for 3 hours. Upon completion of the reaction, the DMF was removed by distillation under reduced pressure. the residue was subjected to liquid-liquid partitioning with 3N HCl aqueous solution and ether. The aqueous phase was extracted three times with ether. The combined organic phases were washed sequentially with water and saturated saline, dried over anhydrous magnesium sulfate and filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by fast column chromatography (silica gel, 25% ethyl acetate/hexane) to afford the title compound 4-difluoromethoxy-3-hydroxybenzaldehyde as a white solid (0.20 g, 38% yield). Melting point 83°C to 85°C.

References

[1] YAN LIN. Isolation, synthesis and structure confirmation of the impurity in crude roflumilast product[J]. Research on Chemical Intermediates, 2012. DOI:10.1007/s11164-012-0823-3.

4-Difluoromethoxy-3-hydroxybenzaldehyde Preparation Products And Raw materials

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View Lastest Price from 4-Difluoromethoxy-3-hydroxybenzaldehyde manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 4-Difluoromethoxy-3-hydroxybenzaldehyde 151103-08-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-10-09

Shaanxi Dideu Medichem Co. Ltd

Product: 4-DifluoroMethoxy-3-hydroxybenzaldehyde 151103-08-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2025-09-23

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-Difluoromethoxy-3-hydroxybenzaldehyde 151103-08-1
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

151103-08-1, 4-Difluoromethoxy-3-hydroxybenzaldehydeRelated Search:

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Benzaldehyde,4-(difluoroMethoxy)-3-hydroxy-

Roflumilast impurity 19

3-Hydroxy-4-diflouromethylbenzaldehyde

4-(Difluoromethoxy)-3-hydroxybenzaldehyde 97%

4-(Difluoromethoxy)-3-hydroxybenzaldehyde97%

3-hydroxy-4-difluoroMethoxy benzaldehyde

4-DIFLUOROMETHOXY-3-HYDROXYBENZALDEHYDE

4-DifL

uoromethoxy-3-hydroxybenzaL

4-DIFLUOROMETHOXY-3-HYDROXYBENZALDEHYDE 151103-08-1

4-(Difluoiromethoxy)-3-Hydroxybenzaldehyde

4-Difluoromethoxy-3-hydroxybenzaldehyde, 4-DifluoroMethoxy-3-hydroxybenzaldehyde, 3-Hydroxy-4-difluoromethoxybenzaldehyde, 4-(difluoromethoxy)-3-hydroxybenzaldehyde, Roflumilast impurity 19, Roflumilast-IM F, 3-hydroxy-4-difluoroMethoxy benzaldehyde, 4-(Difluoromethoxy)-3-hydroxybenzaldehyde

4-Di?uoromethoxy-3- hydroxybenzaldehyde

151103-08-1

Roflumilast interemdiate

Aromatics

Intermediates

Aldehydes

Phenyls & Phenyl-Het

Intermediate