Deltarasin
- Product Name
- Deltarasin
- CAS No.
- 1440898-61-2
- Chemical Name
- Deltarasin
- Synonyms
- Deltarasin;deltarasine;Deltarasin-HCl;Deltarasin USP/EP/BP;Deltarasin,Phosphodiesterase (PDE),inhibit,Inhibitor,Ras;(S)-1-benzyl-2-(4-(2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole;2-[4-[(2S)-2-(2-Phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-1H-benzimidazole;1H-Benzimidazole,2-[4-[(2S)-2-(2-phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-
- CBNumber
- CB22666619
- Molecular Formula
- C40H37N5O
- Formula Weight
- 603.75
- MOL File
- 1440898-61-2.mol
Deltarasin Property
- Boiling point:
- 824.3±75.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- solid
- pka
- 10.35±0.10(Predicted)
- color
- White
- CAS DataBase Reference
- 1440898-61-2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 5424
- Product name
- Deltarasin
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $254
- Updated
- 2021/12/16
- Product number
- 446059
- Product name
- Deltarasin
- Packaging
- 2.5mg
- Price
- $425
- Updated
- 2021/12/16
- Product number
- 255122
- Product name
- Deltarasin
- Packaging
- 10mg
- Price
- $545
- Updated
- 2021/12/16
- Product number
- D231315
- Product name
- Deltarasin
- Packaging
- 5mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- CS-1611
- Product name
- Deltarasin
- Purity
- 96.32%
- Packaging
- 10mg
- Price
- $252
- Updated
- 2021/12/16
Deltarasin Chemical Properties,Usage,Production
Uses
Deltarasin is an inhibitior of KRAS-PDEδ which has been shown to impair oncogenic signalling.
Biological Activity
the kras oncogene product is considered a major target in anticancer drug discovery. interfering with binding of mammalian pdeδ to kras by means of small molecules provides a novel opportunity to suppress oncogenic ras signalling by altering its localization to endomembranes. deltarasin is an inhibitor of the kras-pdeδ interaction to impair oncogenic kras signalling.
in vitro
within a minute, 5 mm of deltarasin completely inhibited pdeδ-kras interaction and released the insolubilized mcitrine-rheb/kras6q to the endomembrane system. this showed that deltarasin interfered with the binding of kras to pdeδ in cells and thereby inhibited its solubilization [1].
in vivo
a clear dose-dependent reduction in panc-tu-i tumour growth rate could be observed in deltarasin treated mice with respect to the vehicle-injected controls, where the growth of tumours in mice that were treated with 10mg kg/1 bid deltarasin was almost completely blocked [1].
References
[1] zimmermann g, papke b, ismail s, vartak n, chandra a, hoffmann m, hahn sa, triola g, wittinghofer a, bastiaens pi, waldmann h. small molecule inhibition of the kras-pdeδ interaction impairs oncogenic kras signalling. nature. 2013;497(7451):638-42.
Deltarasin Preparation Products And Raw materials
Raw materials
Preparation Products
Deltarasin Suppliers
- Tel
- --
- Fax
- --
- info@axonmedchem.com
- Country
- The Netherlands
- ProdList
- 477
- Advantage
- 30
View Lastest Price from Deltarasin manufacturers
- Product
- Deltarasin 1440898-61-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99% HPLC
- Supply Ability
- 2000tons
- Release date
- 2019-12-30
- Product
- Deltarasin 1440898-61-2
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-21