Deltarasin

Product Name: Deltarasin
CAS No.: 1440898-61-2
Chemical Name: Deltarasin
Synonyms: Deltarasin;deltarasine;Deltarasin-HCl;Deltarasin USP/EP/BP;Deltarasin,Phosphodiesterase (PDE),inhibit,Inhibitor,Ras;(S)-1-benzyl-2-(4-(2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole;2-[4-[(2S)-2-(2-Phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-1H-benzimidazole;1H-Benzimidazole,2-[4-[(2S)-2-(2-phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-
CBNumber: CB22666619
Molecular Formula: C40H37N5O
Formula Weight: 603.75
MOL File: 1440898-61-2.mol

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Deltarasin Property

Boiling point:: 824.3±75.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: solid
pka: 10.35±0.10(Predicted)
color: White
CAS DataBase Reference: 1440898-61-2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 5424
Product name: Deltarasin
Purity: ≥99%(HPLC)
Packaging: 10
Price: $254
Updated: 2021/12/16

Usbiological

Product number: 446059
Product name: Deltarasin
Packaging: 2.5mg
Price: $425
Updated: 2021/12/16

Usbiological

Product number: 255122
Product name: Deltarasin
Packaging: 10mg
Price: $545
Updated: 2021/12/16

TRC

Product number: D231315
Product name: Deltarasin
Packaging: 5mg
Price: $185
Updated: 2021/12/16

ChemScene

Product number: CS-1611
Product name: Deltarasin
Purity: 96.32%
Packaging: 10mg
Price: $252
Updated: 2021/12/16

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Deltarasin Chemical Properties,Usage,Production

Uses

Deltarasin is an inhibitior of KRAS-PDEδ which has been shown to impair oncogenic signalling.

Biological Activity

the kras oncogene product is considered a major target in anticancer drug discovery. interfering with binding of mammalian pdeδ to kras by means of small molecules provides a novel opportunity to suppress oncogenic ras signalling by altering its localization to endomembranes. deltarasin is an inhibitor of the kras-pdeδ interaction to impair oncogenic kras signalling.

in vitro

within a minute, 5 mm of deltarasin completely inhibited pdeδ-kras interaction and released the insolubilized mcitrine-rheb/kras6q to the endomembrane system. this showed that deltarasin interfered with the binding of kras to pdeδ in cells and thereby inhibited its solubilization [1].

in vivo

a clear dose-dependent reduction in panc-tu-i tumour growth rate could be observed in deltarasin treated mice with respect to the vehicle-injected controls, where the growth of tumours in mice that were treated with 10mg kg/1 bid deltarasin was almost completely blocked [1].

References

[1] zimmermann g, papke b, ismail s, vartak n, chandra a, hoffmann m, hahn sa, triola g, wittinghofer a, bastiaens pi, waldmann h. small molecule inhibition of the kras-pdeδ interaction impairs oncogenic kras signalling. nature. 2013;497(7451):638-42.

Deltarasin Preparation Products And Raw materials

Raw materials

Preparation Products

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Deltarasin Suppliers

China 53 India 1 The Netherlands 1 United States 11 Global 66

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
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Email: info@adooq.com
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ProdList: 2782
Advantage: 58

BOC Sciences

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Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
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TargetMol Chemicals Inc.

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ProdList: 38632
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ApexBio Technology

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ChemieTek

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MedChemExpress

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Country: United States
ProdList: 6398
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View Lastest Price from Deltarasin manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Deltarasin 1440898-61-2
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99% HPLC
Supply Ability: 2000tons
Release date: 2019-12-30

Career Henan Chemical Co

Product: Deltarasin 1440898-61-2
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-21

1440898-61-2, DeltarasinRelated Search:

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Deltarasin

Deltarasin-HCl

2-[4-[(2S)-2-(2-Phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-1H-benzimidazole

1H-Benzimidazole,2-[4-[(2S)-2-(2-phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-

deltarasine

Deltarasin USP/EP/BP

(S)-1-benzyl-2-(4-(2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole

Deltarasin,Phosphodiesterase (PDE),inhibit,Inhibitor,Ras

1440898-61-2

C40H37N5O

Inhibitors

API