JNK inhibitor

ChemicalBook > CAS DataBase List > JNK inhibitor

Product Name: JNK inhibitor
CAS No.: 1408064-71-0
Chemical Name: JNK inhibitor
Synonyms: CS-2418;JNK-IN-7;JNK inhibitor;JNK inhibitor 7;JNK Inhibitor VII;JNK-IN-7 Only for R&D;Inhibitor,JNK,inhibit,JNK IN 7,JNKIN7;3-(4-(Dimethylamino)but-2-enamido)-N-(4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;(E)-3-(4-(dimethylamino)but-2-enamido)-N-(4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;3-[[4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide
CBNumber: CB22666644
Molecular Formula: C28H27N7O2
Formula Weight: 493.56
MOL File: 1408064-71-0.mol

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JNK inhibitor Property

Density: 1.301±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥24.7 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: solid
pka: 13.34±0.70(Predicted)
color: White to gray

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28831
Product name: JNK Inhibitor VII
Packaging: 1mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 28831
Product name: JNK Inhibitor VII
Packaging: 10mg
Price: $961
Updated: 2024/03/01

Cayman Chemical

Product number: 28831
Product name: JNK Inhibitor VII
Packaging: 5mg
Price: $543
Updated: 2024/03/01

Cayman Chemical

Product number: 28831
Product name: JNK Inhibitor VII
Packaging: 25mg
Price: $1802
Updated: 2024/03/01

ChemScene

Product number: CS-1554
Product name: JNK-IN-7
Purity: 98.41%
Packaging: 100mg
Price: $1906
Updated: 2021/12/16

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JNK inhibitor Chemical Properties,Usage,Production

Description

JNK inhibitor VII is a potent and non-selective inhibitor of JNKs (IC₅₀s = 1.54, 1.99, and 0.75 nM for JNK1, -2, and -3, respectively). It inhibits phosphorylation of c-Jun in HeLa and A375 cells (EC₅₀s = 130 and 244 nM, respectively).

Uses

JNK Inhibitor IX is a potent and selective inhibitor of JNK2 and JNK3. Neuroresearch & Neuroprotective Product.

References

[1]. zhang t, inesta-vaquera f, niepel m et al. discovery of potent and selective covalent inhibitors of jnk. chem biol. 2012 jan 27;19(1):140-54.
[2]. goh et, arthur js, cheung pc et al. identification of the protein kinases that activate the e3 ubiquitin ligase pellino 1 in the innate immune system. biochem j. 2012 jan 1;441(1):339-46.

JNK inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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1408064-71-0, JNK inhibitorRelated Search:

3-[[4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide

JNK-IN-7

JNK inhibitor

CS-2418

JNK inhibitor 7

Benzamide, 3-[[4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-

JNK-IN-7 Only for R&D

(E)-3-(4-(dimethylamino)but-2-enamido)-N-(4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide

3-(4-(Dimethylamino)but-2-enamido)-N-(4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide

Inhibitor,JNK,inhibit,JNK IN 7,JNKIN7

JNK Inhibitor VII

1408064-71-0

MAPK