ChemicalBook > CAS DataBase List > JNK inhibitor

JNK inhibitor

Product Name
JNK inhibitor
CAS No.
1408064-71-0
Chemical Name
JNK inhibitor
Synonyms
CS-2418;JNK-IN-7;JNK inhibitor;JNK inhibitor 7;JNK Inhibitor VII;JNK-IN-7 Only for R&D;Inhibitor,JNK,inhibit,JNK IN 7,JNKIN7;3-(4-(Dimethylamino)but-2-enamido)-N-(4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;(E)-3-(4-(dimethylamino)but-2-enamido)-N-(4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;3-[[4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide
CBNumber
CB22666644
Molecular Formula
C28H27N7O2
Formula Weight
493.56
MOL File
1408064-71-0.mol
More
Less

JNK inhibitor Property

Density 
1.301±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥24.7 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form 
solid
pka
13.34±0.70(Predicted)
color 
White to gray
More
Less

Safety

HS Code 
2933998090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
28831
Product name
JNK Inhibitor VII
Packaging
1mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
28831
Product name
JNK Inhibitor VII
Packaging
10mg
Price
$961
Updated
2024/03/01
Cayman Chemical
Product number
28831
Product name
JNK Inhibitor VII
Packaging
5mg
Price
$543
Updated
2024/03/01
Cayman Chemical
Product number
28831
Product name
JNK Inhibitor VII
Packaging
25mg
Price
$1802
Updated
2024/03/01
ChemScene
Product number
CS-1554
Product name
JNK-IN-7
Purity
98.41%
Packaging
100mg
Price
$1906
Updated
2021/12/16
More
Less

JNK inhibitor Chemical Properties,Usage,Production

Description

JNK inhibitor VII is a potent and non-selective inhibitor of JNKs (IC50s = 1.54, 1.99, and 0.75 nM for JNK1, -2, and -3, respectively). It inhibits phosphorylation of c-Jun in HeLa and A375 cells (EC50s = 130 and 244 nM, respectively).

Uses

JNK Inhibitor IX is a potent and selective inhibitor of JNK2 and JNK3. Neuroresearch & Neuroprotective Product.

References

[1]. zhang t, inesta-vaquera f, niepel m et al. discovery of potent and selective covalent inhibitors of jnk. chem biol. 2012 jan 27;19(1):140-54.
[2]. goh et, arthur js, cheung pc et al. identification of the protein kinases that activate the e3 ubiquitin ligase pellino 1 in the innate immune system. biochem j. 2012 jan 1;441(1):339-46.

JNK inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

JNK inhibitor Suppliers

China 59 India 2 United States 10 Global 71
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58

1408064-71-0, JNK inhibitorRelated Search:


  • 3-[[4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide
  • JNK-IN-7
  • JNK inhibitor
  • CS-2418
  • JNK inhibitor 7
  • Benzamide, 3-[[4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-
  • JNK-IN-7 Only for R&D
  • (E)-3-(4-(dimethylamino)but-2-enamido)-N-(4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
  • 3-(4-(Dimethylamino)but-2-enamido)-N-(4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
  • Inhibitor,JNK,inhibit,JNK IN 7,JNKIN7
  • JNK Inhibitor VII
  • 1408064-71-0
  • MAPK