ChemicalBook > CAS DataBase List > GSK-2110183C

GSK-2110183C

Product Name
GSK-2110183C
CAS No.
1047644-62-1
Chemical Name
GSK-2110183C
Synonyms
Afuresertib;LAE002;ASB-183;LAE-002;Delitinib;GSK2110183C;GSK-2110183C;GSK 2110183C;GSK-21110183;Afuresertibum
CBNumber
CB22667191
Molecular Formula
C18H17Cl2FN4OS
Formula Weight
427.32
MOL File
1047644-62-1.mol
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GSK-2110183C Property

Boiling point:
535.1±50.0 °C(Predicted)
Density 
1.49±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C, protect from light, stored under nitrogen
solubility 
DMSO:62.5(Max Conc. mg/mL);146.26(Max Conc. mM)
Ethanol:85.0(Max Conc. mg/mL);198.91(Max Conc. mM)
pka
13.03±0.46(Predicted)
form 
Powder
color 
White to off-white
InChI
InChI=1S/C18H17Cl2FN4OS/c1-25-16(14(19)9-23-25)13-7-15(27-17(13)20)18(26)24-12(8-22)6-10-3-2-4-11(21)5-10/h2-5,7,9,12H,6,8,22H2,1H3,(H,24,26)/t12-/m0/s1
InChIKey
AFJRDFWMXUECEW-LBPRGKRZSA-N
SMILES
C1(C(N[C@@H](CC2=CC=CC(F)=C2)CN)=O)SC(Cl)=C(C2N(C)N=CC=2Cl)C=1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
A357713
Product name
Afuresertib
Packaging
1mg
Price
$45
Updated
2021/12/16
ChemScene
Product number
CS-3384
Product name
Afuresertib
Purity
99.86%
Packaging
5mg
Price
$84
Updated
2021/12/16
ApexBio Technology
Product number
B4811
Product name
Afuresertib
Packaging
5mg
Price
$105
Updated
2021/12/16
ChemScene
Product number
CS-3384
Product name
Afuresertib
Purity
99.86%
Packaging
10mg
Price
$114
Updated
2021/12/16
ApexBio Technology
Product number
B4811
Product name
Afuresertib
Packaging
10mg
Price
$150
Updated
2021/12/16
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GSK-2110183C Chemical Properties,Usage,Production

Uses

Afuresertib is a potent pan-AKT inhibitor that demonstrated synergy with bortezomib in preclinical models of multiple myeloma.

Definition

ChEBI: N-[(2S)-1-amino-3-(3-fluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methyl-3-pyrazolyl)-2-thiophenecarboxamide is a member of amphetamines.

in vivo

Mice bearing BT474 breast tumor xenografts are dosed orally with either vehicle or GSK2110183 at 10, 30 or 100 mg/kg daily for 21 days which result in 8, 37 and 61% TGI, respectively. Mice tolerated GSK2110183 well, with 1-3% body weight loss reported after 5 days of dosing which recover over the course of the study. Other tumor xenograft models which possess an activation of the Akt pathway are explored to further demonstrate compound efficacy. Mice treated with GSK2110183 at 10, 30 and 100 mg/kg result in 23, 37 and 97% TGI, respectively, of SKOV3 xenografts[1].

IC 50

Akt2: 2 nM (Ki); Akt3: 2.6 nM (Ki); Akt1 E17K mutant: 0.2 nM (IC50); PKCη: 210 nM (IC50); PKC-βI: 430 nM (IC50); PKCθ: 510 nM (IC50); ROCK: 100 nM (IC50)

GSK-2110183C Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK-2110183C Suppliers

China 94 India 1 United States 9 Global 104
SuZhou GoodChemTech Co., Ltd
Tel
18136139868; 18136139868
Email
jinlun@goodchemtech.cn
Country
China
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Shanghai Boyle Chemical Co., Ltd.
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Fax
86-21-57758967
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sales@boylechem.com
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China
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2922
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55
Chembest Research Laboratories Limited
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+86-21-20908456
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021-58180499
Email
sales@BioChemBest.com
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China
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6003
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Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
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China
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12000
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WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
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1077
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BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
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Beijing Yisiyan Technology Research Center
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010-56645598 13366904824
Fax
01062230033
Email
bjkaida@163.com
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China
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Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
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China
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Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
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6295
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AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
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View Lastest Price from GSK-2110183C manufacturers

Career Henan Chemical Co
Product
GSK-2110183C 1047644-62-1
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

1047644-62-1, GSK-2110183CRelated Search:

(+)-JQ-1 3-Chloro-2-methylpropene Panobinostat 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid Veliparib

  • Afuresertib(GSK2110183C)
  • Afuresertib
  • GSK 2110183C
  • GSK2110183C
  • GSK-2110183C
  • N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide
  • Afuresertib, GSK-2110183, GSK-2110183B
  • Delitinib
  • 2-Thiophenecarboxamide, N-[(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-
  • GSK-2110183 Afuresertib
  • GSK-2110183C USP/EP/BP
  • 10-Dimethoxy-2
  • 9-dihydroxyaporphine
  • Afuresertib, 10 mM in DMSO
  • Afuresertibum
  • ASB-183
  • GSK-21110183
  • LAE002
  • LAE-002
  • 1047644-62-1
  • C18H17Cl2FN4OS
  • Inhibitors