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5-allylpyriMidine-4,6-diol

Product Name
5-allylpyriMidine-4,6-diol
CAS No.
16019-30-0
Chemical Name
5-allylpyriMidine-4,6-diol
Synonyms
5-allylpyriMidine-4,6-diol;5-ALLYL-6-HYDROXYPYRIMIDIN-4(3H)-ONE;5-Allyl-4-hydroxy-1H-pyrimidin-6-one;5-allyl-6-hydroxy-1H-pyrimidin-4-one;4-Hydroxy-5-prop-2-enyl-1H-pyrimidin-6-one;4(3H)-Pyrimidinone, 6-hydroxy-5-(2-propen-1-yl)-
CBNumber
CB22667227
Molecular Formula
C7H8N2O2
Formula Weight
152.15
MOL File
16019-30-0.mol
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5-allylpyriMidine-4,6-diol Property

Melting point:
240 °C
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
6.44±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
3318AH
Product name
5-Allylpyrimidine-4,6-diol
Packaging
250mg
Price
$213
Updated
2021/12/16
AK Scientific
Product number
3318AH
Product name
5-Allylpyrimidine-4,6-diol
Packaging
1g
Price
$415
Updated
2021/12/16
ChemScene
Product number
CS-M2479
Product name
5-allylpyrimidine-4,6-diol
Packaging
1g
Price
$450
Updated
2021/12/16
AK Scientific
Product number
3318AH
Product name
5-Allylpyrimidine-4,6-diol
Packaging
5g
Price
$1392
Updated
2021/12/16
Ambeed
Product number
A267986
Product name
5-Allylpyrimidine-4,6-diol
Purity
95%
Packaging
5g
Price
$523
Updated
2021/12/16
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5-allylpyriMidine-4,6-diol Chemical Properties,Usage,Production

Synthesis

2049-80-1

3473-63-0

16019-30-0

Step 2: Ethanol (100 mL) was added to a 500 mL round-bottomed flask under nitrogen protection, followed by the slow addition of sodium metal (4.5 g). After stirring at room temperature until the sodium metal was completely dissolved, the reaction mixture was cooled to 0 °C. Diethyl 2-allylmalonate (12 g) and formamidine acetate (6.24 g) were added sequentially, maintaining a nitrogen atmosphere. The reaction was continued to be stirred at room temperature for 24 hours. Upon completion of the reaction, the reaction was quenched sequentially with acetic acid (20 mL) and water (100 mL). The white precipitate was collected by filtration, washed sequentially with water (4 × 50 mL) and methanol (2 × 50 mL), and dried under vacuum to afford 5-allylpyrimidine-4,6-diol (4 g) as a white solid. NMR hydrogen spectrum (DMSO-d6): δ 2.96 (d, 2H), 4.85 (dd, 1H), 4.91 (dd, 1H), 5.76 (dd, 1H), 7.89 (s, 1H), 11.64 (bs, 2H).

References

[1] Journal of Medicinal Chemistry, 2002, vol. 45, # 17, p. 3639 - 3648
[2] Patent: US2010/144758, 2010, A1. Location in patent: Page/Page column 65-66
[3] Patent: WO2013/138436, 2013, A1. Location in patent: Page/Page column 61

5-allylpyriMidine-4,6-diol Preparation Products And Raw materials

Raw materials

Preparation Products

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5-allylpyriMidine-4,6-diol Suppliers

China 27 India 1 United States 2 Global 30
Nanjing Vital Chemical Co., Ltd.
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Hunan HuaTeng Pharmaceutical Co., Ltd.,
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400-8592883
Fax
0731-82251112
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sales@huatengsci.com
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SanoChem (Chengdu) Tech. Co., Ltd.
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Hangzhou Huarong Pharm Co., Ltd.
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16019-30-0, 5-allylpyriMidine-4,6-diolRelated Search:


  • 5-allylpyriMidine-4,6-diol
  • 5-Allyl-4-hydroxy-1H-pyrimidin-6-one
  • 5-ALLYL-6-HYDROXYPYRIMIDIN-4(3H)-ONE
  • 4(3H)-Pyrimidinone, 6-hydroxy-5-(2-propen-1-yl)-
  • 4-Hydroxy-5-prop-2-enyl-1H-pyrimidin-6-one
  • 5-allyl-6-hydroxy-1H-pyrimidin-4-one
  • 16019-30-0