BM-1074

Product Name: BM-1074
CAS No.: 1391108-10-3
Chemical Name: BM-1074
Synonyms: BM-1074;1H-Pyrrole-3-carboxamide, 5-(4-chlorophenyl)-4-[3-[4-[4-[[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]amino]phenyl]-1-piperazinyl]phenyl]-2-methyl-1-(1-methylethyl)-N-(methylsulfonyl)-
CBNumber: CB22667388
Molecular Formula: C50H57ClN8O7S3
Formula Weight: 1013.68
MOL File: 1391108-10-3.mol

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BM-1074 Property

Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO mg/mL Water mg/mL Ethanol mg/mL
pka: 2.32±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B595855
Product name: BM-1074
Packaging: 10mg
Price: $1680
Updated: 2021/12/16

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BM-1074 Chemical Properties,Usage,Production

Uses

BM-1074 is a potent Bcl-2/Bcl-xL inhibitor which is capable of achieving rapid, complete, and durable tumor regression in vivo.

in vivo

BM-1074 (i.v., 15 mg/kg, daily, 5 days a week for 2 weeks) exhibits the maximum tolerated dose (MTD) (15 mg/kg) and strong antitumor activity in H146 tumor xenograft mice, as well as shows no significant weight loss (<5%) or other signs of toxicity^[1].
BM-1074 (i.v., 15 mg/kg, single) induces strong apoptosis in H146 tumor tissues^[1].

Animal Model:	SCID mice (injected with 5 x 10⁶ H146 cancer cells with Matrigel, subcutaneously)^[1]
Dosage:	15 mg/kg
Administration:	i.v., 15 mg/kg, daily, 5 days a week for 2 weeks
Result:	Showed good toleration and did not cause significant weight loss or other signs of toxicity, also induced completely and persistent tumor regression in the H146 xenograft model.

Animal Model:	SCID mice (injected with 5 x 10⁶ H146 cancer cells with Matrigel, subcutaneously)^[1]
Dosage:	15 mg/kg
Administration:	i.v., 15 mg/kg, single dosage
Result:	Induced robust cleavage of PARP and caspase-3 at both 3 and 6-hr time-points in H146 tumor tissues.

IC 50

Bcl-2: 1.8 nM (IC₅₀); Bcl-xL: 6.9 nM (IC₅₀)

BM-1074 Preparation Products And Raw materials

Raw materials

Preparation Products

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BM-1074 Suppliers

China 26 India 1 United States 2 Global 29

Jinan Trio PharmaTech Co., Ltd.

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1391108-10-3, BM-1074Related Search:

BM-1074

1H-Pyrrole-3-carboxamide, 5-(4-chlorophenyl)-4-[3-[4-[4-[[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]amino]phenyl]-1-piperazinyl]phenyl]-2-methyl-1-(1-methylethyl)-N-(methylsulfonyl)-

1391108-10-3

C50H57ClN8O7S3