ChemicalBook > CAS DataBase List > BM-1074
BM-1074
- Product Name
- BM-1074
- CAS No.
- 1391108-10-3
- Chemical Name
- BM-1074
- Synonyms
- BM-1074;1H-Pyrrole-3-carboxamide, 5-(4-chlorophenyl)-4-[3-[4-[4-[[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]amino]phenyl]-1-piperazinyl]phenyl]-2-methyl-1-(1-methylethyl)-N-(methylsulfonyl)-
- CBNumber
- CB22667388
- Molecular Formula
- C50H57ClN8O7S3
- Formula Weight
- 1013.68
- MOL File
- 1391108-10-3.mol
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BM-1074 Property
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO mg/mL Water mg/mL Ethanol mg/mL
- pka
- 2.32±0.40(Predicted)
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N-Bromosuccinimide Price
TRC
- Product number
- B595855
- Product name
- BM-1074
- Packaging
- 10mg
- Price
- $1680
- Updated
- 2021/12/16
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BM-1074 Chemical Properties,Usage,Production
Uses
BM-1074 is a potent Bcl-2/Bcl-xL inhibitor which is capable of achieving rapid, complete, and durable tumor regression in vivo.
in vivo
BM-1074 (i.v., 15 mg/kg, daily, 5 days a week for 2 weeks) exhibits the maximum tolerated dose (MTD) (15 mg/kg) and strong antitumor activity in H146 tumor xenograft mice, as well as shows no significant weight loss (<5%) or other signs of toxicity[1].
BM-1074 (i.v., 15 mg/kg, single) induces strong apoptosis in H146 tumor tissues[1].
| Animal Model: | SCID mice (injected with 5 x 106 H146 cancer cells with Matrigel, subcutaneously)[1] |
| Dosage: | 15 mg/kg |
| Administration: | i.v., 15 mg/kg, daily, 5 days a week for 2 weeks |
| Result: | Showed good toleration and did not cause significant weight loss or other signs of toxicity, also induced completely and persistent tumor regression in the H146 xenograft model. |
| Animal Model: | SCID mice (injected with 5 x 106 H146 cancer cells with Matrigel, subcutaneously)[1] |
| Dosage: | 15 mg/kg |
| Administration: | i.v., 15 mg/kg, single dosage |
| Result: | Induced robust cleavage of PARP and caspase-3 at both 3 and 6-hr time-points in H146 tumor tissues. |
IC 50
Bcl-2: 1.8 nM (IC50); Bcl-xL: 6.9 nM (IC50)
BM-1074 Preparation Products And Raw materials
Raw materials
Preparation Products
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