GGTI 298 trifluoroacetate salt hydrate
- Product Name
- GGTI 298 trifluoroacetate salt hydrate
- CAS No.
- 1217457-86-7
- Chemical Name
- GGTI 298 trifluoroacetate salt hydrate
- Synonyms
- GGTI-298 TFA;GGTI 298 TFA salt;GGTI298 Trifluoroacetate;WALKWJPZELDSKT-UFABNHQSSA-N;GGTI 298 trifluoroacetate salt hydrate;GGTI 298 TFA SALT;GGTI 298 (TRIFLUOROACETATE SALT);N-[[4-(2-(R)-Amino-3-mercaptopropyl)amino]-2-naphthylbenzoyl]leucine methyl ester trifluoroacetate salt hydrate;(S)-Methyl 2-(4-(((R)-2-amino-3-mercaptopropyl)amino)-2-(naphthalen-1-yl)benzamido)-4-methylpentanoate 2,2,2-trifluoroacetate
- CBNumber
- CB22676894
- Molecular Formula
- C29H34F3N3O5S
- Formula Weight
- 593.66
- MOL File
- 1217457-86-7.mol
GGTI 298 trifluoroacetate salt hydrate Property
- Melting point:
- 99.5-100°C
- storage temp.
- -20°C
- solubility
- DMSO: >20mg/mL
- form
- film &_& lyophilized
- color
- colorless
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- G5169
- Product name
- GGTI 298 trifluoroacetate salt hydrate
- Purity
- ≥90% (HPLC), film
- Packaging
- 250μg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- G5169
- Product name
- GGTI 298 trifluoroacetate salt hydrate
- Purity
- ≥90% (HPLC), film
- Packaging
- 1mg
- Price
- $440
- Updated
- 2024/03/01
- Product number
- 16176
- Product name
- GGTI 298 (trifluoroacetate salt)
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 16176
- Product name
- GGTI 298 (trifluoroacetate salt)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $184
- Updated
- 2024/03/01
- Product number
- 16176
- Product name
- GGTI 298 (trifluoroacetate salt)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $816
- Updated
- 2024/03/01
GGTI 298 trifluoroacetate salt hydrate Chemical Properties,Usage,Production
Uses
GGTI 298 trifluoroacetate salt hydrate has been used as a geranylgeranyltransferase I (GGTase I) inhibitor:
- to study the anticancer effects of statins along with GGTI 298
- to study its combinatorial effects with FTI-277 on statin-mediated activation of extracellular signal-regulated kinase 5 (ERK5) in the human endothelium
- to evaluate the effect of protein geranylgeranylation (GG) inhibition on the breast cancer stem cell (CSC) population
Biochem/physiol Actions
GGTI 298 is a cell-permeable, prodrug form of the geranylgeranyltransferase I (GGTase I) inhibitor GGTI-297. It inhibits the processing of Rap 1A without effecting the processing of H-Ras.
storage
Store at -20°C
GGTI 298 trifluoroacetate salt hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
GGTI 298 trifluoroacetate salt hydrate Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77