ChemicalBook > CAS DataBase List > GGTI 298 trifluoroacetate salt hydrate

GGTI 298 trifluoroacetate salt hydrate

Product Name
GGTI 298 trifluoroacetate salt hydrate
CAS No.
1217457-86-7
Chemical Name
GGTI 298 trifluoroacetate salt hydrate
Synonyms
GGTI-298 TFA;GGTI 298 TFA salt;GGTI298 Trifluoroacetate;WALKWJPZELDSKT-UFABNHQSSA-N;GGTI 298 trifluoroacetate salt hydrate;GGTI 298 TFA SALT;GGTI 298 (TRIFLUOROACETATE SALT);N-[[4-(2-(R)-Amino-3-mercaptopropyl)amino]-2-naphthylbenzoyl]leucine methyl ester trifluoroacetate salt hydrate;(S)-Methyl 2-(4-(((R)-2-amino-3-mercaptopropyl)amino)-2-(naphthalen-1-yl)benzamido)-4-methylpentanoate 2,2,2-trifluoroacetate
CBNumber
CB22676894
Molecular Formula
C29H34F3N3O5S
Formula Weight
593.66
MOL File
1217457-86-7.mol
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GGTI 298 trifluoroacetate salt hydrate Property

Melting point:
99.5-100°C
storage temp. 
-20°C
solubility 
DMSO: >20mg/mL
form 
film &_& lyophilized
color 
colorless
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G5169
Product name
GGTI 298 trifluoroacetate salt hydrate
Purity
≥90% (HPLC), film
Packaging
250μg
Price
$118
Updated
2024/03/01
Sigma-Aldrich
Product number
G5169
Product name
GGTI 298 trifluoroacetate salt hydrate
Purity
≥90% (HPLC), film
Packaging
1mg
Price
$440
Updated
2024/03/01
Cayman Chemical
Product number
16176
Product name
GGTI 298 (trifluoroacetate salt)
Purity
≥95%
Packaging
500μg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
16176
Product name
GGTI 298 (trifluoroacetate salt)
Purity
≥95%
Packaging
1mg
Price
$184
Updated
2024/03/01
Cayman Chemical
Product number
16176
Product name
GGTI 298 (trifluoroacetate salt)
Purity
≥95%
Packaging
5mg
Price
$816
Updated
2024/03/01
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GGTI 298 trifluoroacetate salt hydrate Chemical Properties,Usage,Production

Uses

GGTI 298 trifluoroacetate salt hydrate has been used as a geranylgeranyltransferase I (GGTase I) inhibitor:

  • to study the anticancer effects of statins along with GGTI 298
  • to study its combinatorial effects with FTI-277 on statin-mediated activation of extracellular signal-regulated kinase 5 (ERK5) in the human endothelium
  • to evaluate the effect of protein geranylgeranylation (GG) inhibition on the breast cancer stem cell (CSC) population

Biochem/physiol Actions

GGTI 298 is a cell-permeable, prodrug form of the geranylgeranyltransferase I (GGTase I) inhibitor GGTI-297. It inhibits the processing of Rap 1A without effecting the processing of H-Ras.

storage

Store at -20°C

GGTI 298 trifluoroacetate salt hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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GGTI 298 trifluoroacetate salt hydrate Suppliers

China 35 India 2 United Kingdom 1 United States 9 Global 47
MedChemexpress LLC
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InvivoChem
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Aladdin Scientific
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+1-+1(833)-552-7181
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sales@aladdinsci.com
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TargetMol Chemicals Inc.
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United States
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BOC Sciences
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Cayman Chemical Company
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MedChemExpress
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Riedel-de Haen AG
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1217457-86-7, GGTI 298 trifluoroacetate salt hydrateRelated Search:

Silver

  • GGTI 298 trifluoroacetate salt hydrate
  • N-[[4-(2-(R)-Amino-3-mercaptopropyl)amino]-2-naphthylbenzoyl]leucine methyl ester trifluoroacetate salt hydrate
  • GGTI-298 TFA
  • GGTI298 Trifluoroacetate
  • WALKWJPZELDSKT-UFABNHQSSA-N
  • GGTI 298 TFA salt
  • GGTI 298 TFA SALT;GGTI 298 (TRIFLUOROACETATE SALT)
  • (S)-Methyl 2-(4-(((R)-2-amino-3-mercaptopropyl)amino)-2-(naphthalen-1-yl)benzamido)-4-methylpentanoate 2,2,2-trifluoroacetate
  • 1217457-86-7