Ro 25-6981 (Maleate)
- Product Name
- Ro 25-6981 (Maleate)
- CAS No.
- 1312991-76-6
- Chemical Name
- Ro 25-6981 (Maleate)
- Synonyms
- [R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate salt;1-Piperidinepropanol, α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-, ( αR,βS)-, (2Z)-2-butenedioate (1:1)
- CBNumber
- CB22677053
- Molecular Formula
- C26H33NO6
- Formula Weight
- 455.55
- MOL File
- 1312991-76-6.mol
Ro 25-6981 (Maleate) Property
- storage temp.
- 2-8°C
- solubility
- H2O: soluble2mg/mL (clear solution, warmed)
- form
- powder
- color
- white to beige
- optical activity
- [α]/D +15 to +22°, c = 1 in methanol
Safety
- Hazard Codes
- Xi,N
- Risk Statements
- 36/37/38-50
- Safety Statements
- 26-61
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H400Very toxic to aquatic life
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0495
- Product name
- Ro 25-6981 maleate salt
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $159
- Updated
- 2024/03/01
- Product number
- SML0495
- Product name
- Ro 25-6981 maleate salt
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $507
- Updated
- 2024/03/01
- Product number
- 14578
- Product name
- Ro 25-6981 (maleate)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 14578
- Product name
- Ro 25-6981 (maleate)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- 14578
- Product name
- Ro 25-6981 (maleate)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $820
- Updated
- 2024/03/01
Ro 25-6981 (Maleate) Chemical Properties,Usage,Production
Uses
Ro 25-6981 maleate is a potent NMDA receptor antagonist.
Definition
ChEBI: Ro 25-6981 maleate is the maleic acid salt of Ro 25-6981. It is a potent and selective antagonist of GluN2B-containing NMDA receptors. It has a role as an anticonvulsant, an antidepressant, a neuroprotective agent and a NMDA receptor antagonist. It contains a Ro 25-6981(1+).
Biochem/physiol Actions
Ro 25-6981 maleate salt is a potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit with IC50 values of .009 μM for NR2B vs. 52 μM for NR2A subunits. Ro 25-6981 has been shown to have neuroprotectant effects and to reduce inflammatory and neuropathic pain in rodent models.
storage
Room temperature (desiccate)