N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE
- Product Name
- N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE
- CAS No.
- 31750-48-8
- Chemical Name
- N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE
- Synonyms
- ici55,548;desmethyltamoxifen;n-desmethyltamoxifen;Tamoxifen EP Impurity F;N-DESMETHYL TAMOXIFEN HCL;tamoxifen citrate impurity F;N-DEMETHYLTAMOXIFEN, HYDROCHLORIDE;N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE;2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(p-((z)-ethylamin;2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(4-((z)-ethanamin
- CBNumber
- CB2267847
- Molecular Formula
- C25H27NO
- Formula Weight
- 357.49
- MOL File
- 31750-48-8.mol
N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE Property
- Boiling point:
- 485.8±33.0 °C(Predicted)
- Density
- 1.047±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 72 mg/mL (201.40 mM);Ethanol: 36 mg/mL (100.70 mM)
- pka
- 9.38±0.10(Predicted)
- Water Solubility
- Water: Insoluble
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H350May cause cancer
H360May damage fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P314Get medical advice/attention if you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D3220-90M
- Product name
- N-Desmethyltamoxifen, Hydrochloride
- Packaging
- 5mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- 34558
- Product name
- N-Desmethyltamoxifen HCl
- Packaging
- 5mg
- Price
- $1440
- Updated
- 2021/12/16
- Product number
- DM-3492
- Product name
- 2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N-methylethanamineHCl
- Purity
- 97%
- Packaging
- 1g
- Price
- $220
- Updated
- 2021/12/16
N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE Chemical Properties,Usage,Production
Definition
ChEBI: N-Desmethyltamoxifen is a stilbenoid.
Biological Activity
N-Desmethyltamoxifen is the main metabolite of Tamoxifen in the human body. N-Desmethyltamoxifen, a weaker antiestrogen, is a protein kinase C (PKC) inhibitor ten times stronger than Tamoxifen. It is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis and sphingosine phosphorylation.
in vitro
N-desmethyltamoxifen (20-500 ng/ml; 48 hours) has a profound inhibitory effect upon all seven glioma lines (T98G, U87, U138, U373, ALW, AUK, CAS cells).
It inhibits growth of MCF 7 human mammary carcinoma cells.
N-desmethyltamoxifen, resulting from the CYP3A4/5-mediated catalysis of tamoxifen, is the major primary quantitative metabolite of tamoxifen.
Cell Viability Assay
| Cell Line: | MCF 7 human mammary carcinoma cells |
| Concentration: | 1.5, 2.5, 5, 7.5, 10 μM | td>
| Incubation Time: | 114 hours |
| Result: | Inhibits growth of MCF 7 human mammary carcinoma cells |
target
| PKC
| Estrogen Receptor
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