5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
- Product Name
- 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
- CAS No.
- 1052114-81-4
- Chemical Name
- 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
- Synonyms
- 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic ac;5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid;5-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-Pyridinecarboxylic acid;3-Pyridinecarboxylic acid, 5-(4-fluorophenyl)-1,4-dihydro-4-oxo-
- CBNumber
- CB22684499
- Molecular Formula
- C12H8FNO3
- Formula Weight
- 233.2
- MOL File
- 1052114-81-4.mol
5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Property
- Boiling point:
- 423.3±45.0 °C(Predicted)
- Density
- 1.437±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -0.34±0.20(Predicted)
- Appearance
- White to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8710DP
- Product name
- 5-(4-Fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylicacid
- Packaging
- 1g
- Price
- $271
- Updated
- 2021/12/16
- Product number
- A113559
- Product name
- 5-(4-Fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylicacid
- Purity
- 97%
- Packaging
- 100mg
- Price
- $43
- Updated
- 2021/12/16
- Product number
- A113559
- Product name
- 5-(4-Fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylicacid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $63
- Updated
- 2021/12/16
- Product number
- A113559
- Product name
- 5-(4-Fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $157
- Updated
- 2021/12/16
- Product number
- CD11359500
- Product name
- 5-(4-Fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylicacid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $230
- Updated
- 2021/12/16
5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Chemical Properties,Usage,Production
Synthesis
1052114-80-3
1052114-81-4
Example A8: Example A7 (0.750 g, 2.87 mmol) was suspended in 3 M NaOH aqueous solution (7.5 mL, 22.50 mmol) and heated to reflux at 100 °C for 1.5 hrs. Upon completion of the reaction, the mixture was cooled to room temperature and slowly acidified to pH 2 with 3 M aqueous HCl. The precipitated white solid was collected by vacuum filtration and washed with deionized water and dried to afford 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid (669 mg, 100% yield). The product was analyzed by mass spectrometry (ESI), m/z: 234.1 ([M + H]+).
References
[1] Patent: WO2014/145004, 2014, A1. Location in patent: Paragraph 0111
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 17, p. 5330 - 5341
[3] Patent: WO2009/94417, 2009, A1. Location in patent: Page/Page column 28; 35-36
[4] Patent: WO2014/713, 2014, A1. Location in patent: Page/Page column 38
5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Suppliers
- Tel
- --
- Fax
- --
- info@synthonix.com
- Country
- United States
- ProdList
- 6872
- Advantage
- 58