Kif15-IN-1

Product Name: Kif15-IN-1
CAS No.: 672926-32-8
Chemical Name: Kif15-IN-1
Synonyms: Kif15-IN-1;Kif15 inhibitor 1;Kif-15-IN-1,Kif15IN1,Kif15 IN 1;Ethyl (S)-2-(2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-3-methylbutanamido)-4-methylthiazole-5-carboxylate;2-[[(2S)-2-(1,4-Dihydro-2,4-dioxo-3(2H)-quinazolinyl)-3-methyl-1-oxobutyl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester;5-Thiazolecarboxylic acid, 2-[[(2S)-2-(1,4-dihydro-2,4-dioxo-3(2H)-quinazolinyl)-3-methyl-1-oxobutyl]amino]-4-methyl-, ethyl ester
CBNumber: CB22685926
Molecular Formula: C20H22N4O5S
Formula Weight: 430.48
MOL File: 672926-32-8.mol

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Kif15-IN-1 Property

Density: 1.361±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in DMSO; ≥19.2 mg/mL in EtOH
form: Solid
pka: 7.73±0.50(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B3280
Product name: Kif15-IN-1
Packaging: 2mg
Price: $341
Updated: 2021/12/16

ChemScene

Product number: CS-2697
Product name: Kif15-IN-1
Purity: 99.53%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ApexBio Technology

Product number: B3280
Product name: Kif15-IN-1
Packaging: 5mg
Price: $513
Updated: 2021/12/16

ChemScene

Product number: CS-2697
Product name: Kif15-IN-1
Purity: 99.53%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

ApexBio Technology

Product number: B3280
Product name: Kif15-IN-1
Packaging: 10mg
Price: $733
Updated: 2021/12/16

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Kif15-IN-1 Chemical Properties,Usage,Production

Uses

Kif15-IN-1 is an inhibitor of the mitotic Kinesin family member 15 (Kif15), and is used for the research of cellular proliferative diseases.

Biological Activity

kif15-in-1, a potent kif15 kinesin inhibitor; inhibits cellular proliferation in various tumor cell lines [1].kif15,also known as kinesin-12 and hklp2, is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth [2]. kif15 is a kinesin-related protein whose mitotic homologues are believed to crosslink and immobilize spindle microtubules.kif15 is involved in maintaining bipolar microtubulespindle apparatusin dividing cells and shares redundant functions with kif11 [3].

IC 50

KIF15

References

[1]. preparation of quinazolinediones as kif15 kinesin inhibitors for treating cellular proliferative disorders. pat. appl. publ. (2004), us 20040053948 a1 20040318.
[2]. buster d w, baird d h, yu w, et al. expression of the mitotic kinesin kif15 in postmitotic neurons: implications for neuronal migration and development[j]. journal of neurocytology, 2003, 32(1): 79-96.
[3]. vanneste d, takagi m, imamoto n, et al. the role of hklp2 in the stabilization and maintenance of spindle bipolarity[j]. current biology, 2009, 19(20): 1712-1717.

Kif15-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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Kif15-IN-1 Suppliers

China 30 United States 7 Global 37

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672926-32-8, Kif15-IN-1Related Search:

Kif15-IN-1

2-[[(2S)-2-(1,4-Dihydro-2,4-dioxo-3(2H)-quinazolinyl)-3-methyl-1-oxobutyl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester

Kif15 inhibitor 1

5-Thiazolecarboxylic acid, 2-[[(2S)-2-(1,4-dihydro-2,4-dioxo-3(2H)-quinazolinyl)-3-methyl-1-oxobutyl]amino]-4-methyl-, ethyl ester

Kif-15-IN-1,Kif15IN1,Kif15 IN 1

Ethyl (S)-2-(2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-3-methylbutanamido)-4-methylthiazole-5-carboxylate

672926-32-8