ChemicalBook > CAS DataBase List > Kif15-IN-1

Kif15-IN-1

Product Name
Kif15-IN-1
CAS No.
672926-32-8
Chemical Name
Kif15-IN-1
Synonyms
Kif15-IN-1;Kif15 inhibitor 1;Kif-15-IN-1,Kif15IN1,Kif15 IN 1;2-[[(2S)-2-(1,4-Dihydro-2,4-dioxo-3(2H)-quinazolinyl)-3-methyl-1-oxobutyl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester;5-Thiazolecarboxylic acid, 2-[[(2S)-2-(1,4-dihydro-2,4-dioxo-3(2H)-quinazolinyl)-3-methyl-1-oxobutyl]amino]-4-methyl-, ethyl ester
CBNumber
CB22685926
Molecular Formula
C20H22N4O5S
Formula Weight
430.48
MOL File
672926-32-8.mol
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Kif15-IN-1 Property

Density 
1.361±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; insoluble in DMSO; ≥19.2 mg/mL in EtOH
form 
Solid
pka
7.73±0.50(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology
Product number
B3280
Product name
Kif15-IN-1
Packaging
2mg
Price
$341
Updated
2021/12/16
ChemScene
Product number
CS-2697
Product name
Kif15-IN-1
Purity
99.53%
Packaging
5mg
Price
$420
Updated
2021/12/16
ApexBio Technology
Product number
B3280
Product name
Kif15-IN-1
Packaging
5mg
Price
$513
Updated
2021/12/16
ApexBio Technology
Product number
B3280
Product name
Kif15-IN-1
Packaging
10mg
Price
$733
Updated
2021/12/16
ChemScene
Product number
CS-2697
Product name
Kif15-IN-1
Purity
99.53%
Packaging
50mg
Price
$1800
Updated
2021/12/16
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Kif15-IN-1 Chemical Properties,Usage,Production

Biological Activity

kif15-in-1, a potent kif15 kinesin inhibitor; inhibits cellular proliferation in various tumor cell lines [1].kif15,also known as kinesin-12 and hklp2, is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth [2]. kif15 is a kinesin-related protein whose mitotic homologues are believed to crosslink and immobilize spindle microtubules.kif15 is involved in maintaining bipolar microtubulespindle apparatusin dividing cells and shares redundant functions with kif11 [3].

References

[1]. preparation of quinazolinediones as kif15 kinesin inhibitors for treating cellular proliferative disorders. pat. appl. publ. (2004), us 20040053948 a1 20040318.
[2]. buster d w, baird d h, yu w, et al. expression of the mitotic kinesin kif15 in postmitotic neurons: implications for neuronal migration and development[j]. journal of neurocytology, 2003, 32(1): 79-96.
[3]. vanneste d, takagi m, imamoto n, et al. the role of hklp2 in the stabilization and maintenance of spindle bipolarity[j]. current biology, 2009, 19(20): 1712-1717.

Kif15-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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Kif15-IN-1 Suppliers

China 23 United States 7 Global 30
MedChemexpress LLC
Tel
021-58955995
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609-228-5909
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sales@medchemexpress.cn
Country
United States
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Musechem
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+1-800-259-7612
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+1-800-259-7612
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info@musechem.com
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
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58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
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sales@aladdinsci.com
Country
United States
ProdList
52924
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58
ApexBio Technology
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sales@apexbt.com
Country
United States
ProdList
6251
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58
BOC Sciences
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16314854226
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info@bocsci.com
Country
United States
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9923
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MedChemExpress
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sales@medchemexpress.com
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United States
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672926-32-8, Kif15-IN-1Related Search:


  • Kif15-IN-1
  • 2-[[(2S)-2-(1,4-Dihydro-2,4-dioxo-3(2H)-quinazolinyl)-3-methyl-1-oxobutyl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester
  • Kif15 inhibitor 1
  • 5-Thiazolecarboxylic acid, 2-[[(2S)-2-(1,4-dihydro-2,4-dioxo-3(2H)-quinazolinyl)-3-methyl-1-oxobutyl]amino]-4-methyl-, ethyl ester
  • Kif-15-IN-1,Kif15IN1,Kif15 IN 1
  • 672926-32-8