TUG 891
- Product Name
- TUG 891
- CAS No.
- 1374516-07-0
- Chemical Name
- TUG 891
- Synonyms
- CS-2448;TUG 891;TUG 891;TUG-891;TUG-891, 10 mM in DMSO;Inhibitor,inhibit,Free Fatty Acid Receptor,TUG-891,FFAR;3-{4-[(4-Fluoro-4'-methyl-2-biphenylyl)methoxy]phenyl}propanoic acid;3-(4-{[5-fluoro-2-(4-methylphenyl)phenyl]methoxy}phenyl)propanoic acid;4-[(4-Fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]benzenepropanoic acid;4-[(4-Fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]-benzenepropanoic acid;3-(4-((4-fluoro-4'-methyl-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoicacid
- CBNumber
- CB22701695
- Molecular Formula
- C23H21FO3
- Formula Weight
- 364.41
- MOL File
- 1374516-07-0.mol
TUG 891 Property
- Boiling point:
- 540.8±50.0 °C(Predicted)
- Density
- 1.199±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO:30.0(Max Conc. mg/mL);82.32(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);13.72(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);2.74(Max Conc. mM) - form
- Powder
- pka
- 4.70±0.10(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1914
- Product name
- TUG-891
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $63
- Updated
- 2024/03/01
- Product number
- SML1914
- Product name
- TUG-891
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $254.4
- Updated
- 2024/03/01
- Product number
- 17035
- Product name
- TUG-891
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $34
- Updated
- 2024/03/01
- Product number
- 17035
- Product name
- TUG-891
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 17035
- Product name
- TUG-891
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $166
- Updated
- 2024/03/01
TUG 891 Chemical Properties,Usage,Production
Uses
TUG 891 is a potent and selective GPR120 agonist as a new potential target for treatment of type 2 diabetes and metabolic diseases.
Biological Activity
TUG-891 is an orally active, potent and selective agonist for human long chain free fatty acid (FFA) receptor FFA4/GPR120 (pEC50 of receptor β-arrestin-2 recruitment = 7.36/FFA4 vs. 4.19/FFA1 HEK transfectants; pEC50 of calcium mobilization = 7.02/FFA4 vs. 5.30/FFA1 transfectants), while exhibiting no activity toward human short-chain FFA receptors FFA2/GPR43 and FFA3/GPR41. TUG-891 also exhibits potent partial agonist activity toward murine FFA4 (pEC50 = 7.77, 75% efficacy by β-arrestin-2 recruitment assay; pEC50 = 6.89 by calcium mobilization), albeit with a reduced selectivity over mFFA1 (pEC50 = 5.92 by β-arrestin-2 recruitment and 6.41 by by calcium mobilization). When administered via water intake (~20 mg/kg/day), TUG-891 is reported to reverse food intake increases and body weight gains among mice subjected to sleep fragmentation, and significantly attenuate visceral white adipose tissue inflammation as well as insulin resistance.', 'TUG-891, a GPR120 agonist helps to stimulate metabolic health by inducing mitochondrial respiration in brown fat. It is capable of enhancing lipid oxidation and decreasing f at mass in mice.
storage
Store at RT
TUG 891 Preparation Products And Raw materials
Raw materials
Preparation Products
TUG 891 Suppliers
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View Lastest Price from TUG 891 manufacturers
- Product
- TUG 891 1374516-07-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2019-12-25