6-BROMO-1-ISOPROPYL-1H-INDAZOLE-4-CARBOXYLIC ACID

Product Name: 6-BROMO-1-ISOPROPYL-1H-INDAZOLE-4-CARBOXYLIC ACID
CAS No.: 1346702-54-2
Chemical Name: 6-BROMO-1-ISOPROPYL-1H-INDAZOLE-4-CARBOXYLIC ACID
Synonyms: 6-Bromo-1-isopropylindazole-4-carboxylic Acid;6-bromo-1-propan-2-ylindazole-4-carboxylic acid;6-BROMO-1-ISOPROPYL-1H-INDAZOLE-4-CARBOXYLIC ACID;6-bromo-1-(propan-2-yl)-1H-indazole-4-carboxylic acid;1H-Indazole-4-carboxylic acid, 6-bromo-1-(1-methylethyl)-
CBNumber: CB22705138
Molecular Formula: C11H11BrN2O2
Formula Weight: 283.12
MOL File: 1346702-54-2.mol

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6-BROMO-1-ISOPROPYL-1H-INDAZOLE-4-CARBOXYLIC ACID Property

storage temp.: Sealed in dry,Room Temperature
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B681320
Product name: 6-Bromo-1-isopropyl-1h-indazole-4-carboxylicAcid
Packaging: 50mg
Price: $155
Updated: 2021/12/16

AK Scientific

Product number: 1813AQ
Product name: 6-BROMO-1-ISOPROPYL-1H-INDAZOLE-4-CARBOXYLICACID
Packaging: 100mg
Price: $252.8
Updated: 2021/12/16

Ambeed

Product number: A319544
Product name: 6-Bromo-1-isopropyl-1H-indazole-4-carboxylicacid
Purity: 97%
Packaging: 100mg
Price: $80
Updated: 2021/12/16

Chemenu

Product number: CM261250
Product name: 6-Bromo-1-isopropyl-1H-indazole-4-carboxylicacid
Purity: 95+%
Packaging: 100mg
Price: $89
Updated: 2021/12/16

Ambeed

Product number: A319544
Product name: 6-Bromo-1-isopropyl-1H-indazole-4-carboxylicacid
Purity: 97%
Packaging: 250mg
Price: $144
Updated: 2021/12/16

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6-BROMO-1-ISOPROPYL-1H-INDAZOLE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

1346702-52-0

1346702-54-2

b) Methyl 6-bromo-1-isopropyl-1H-indazole-4-carboxylate (0.58 g, 1.952 mmol) was dissolved in a solvent mixture of methanol (12 mL) and tetrahydrofuran (3 mL). A 3N NaOH solution (3.25 mL, 9.76 mmol) was added slowly via syringe and the reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the volatile solvent was removed under vacuum and the residue was diluted with water and the pH was adjusted to 4-5 by slow dropwise addition of 1 N HCl. The aqueous phase was extracted with a 20% THF/EtOAc solvent mixture (3 times). The organic phases were combined, washed with saturated brine, dried over anhydrous MgSO4, filtered and concentrated to afford 6-bromo-1-isopropyl-1H-indazole-4-carboxylic acid (0.52 g, 94% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6) and LC-MS (ES): 1H NMR δ 13.54 (s, 1H), 8.36-8.43 (m, 2H), 7.82 (d, J = 1.52 Hz, 1H), 5.11 (quin, J = 6.57 Hz, 1H), 1.48 (s, 3H), 1.47 ( s, 3H); LC-MS (ES) [M + H]+ 283.4/285.2.

References

[1] Patent: WO2011/140325, 2011, A1. Location in patent: Page/Page column 41
[2] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 12, p. 1091 - 1096
[3] Patent: WO2012/118812, 2012, A2. Location in patent: Page/Page column 320-321

6-BROMO-1-ISOPROPYL-1H-INDAZOLE-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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6-BROMO-1-ISOPROPYL-1H-INDAZOLE-4-CARBOXYLIC ACID Suppliers

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1346702-54-2, 6-BROMO-1-ISOPROPYL-1H-INDAZOLE-4-CARBOXYLIC ACIDRelated Search:

6-BROMO-1-ISOPROPYL-1H-INDAZOLE-4-CARBOXYLIC ACID

6-bromo-1-propan-2-ylindazole-4-carboxylic acid

1H-Indazole-4-carboxylic acid, 6-bromo-1-(1-methylethyl)-

6-bromo-1-(propan-2-yl)-1H-indazole-4-carboxylic acid

6-Bromo-1-isopropylindazole-4-carboxylic Acid

1346702-54-2