6-BROMO-1-ISOPROPYL-1H-INDAZOLE-4-CARBOXYLIC ACID
- Product Name
- 6-BROMO-1-ISOPROPYL-1H-INDAZOLE-4-CARBOXYLIC ACID
- CAS No.
- 1346702-54-2
- Chemical Name
- 6-BROMO-1-ISOPROPYL-1H-INDAZOLE-4-CARBOXYLIC ACID
- Synonyms
- 6-Bromo-1-isopropylindazole-4-carboxylic Acid;6-bromo-1-propan-2-ylindazole-4-carboxylic acid;6-BROMO-1-ISOPROPYL-1H-INDAZOLE-4-CARBOXYLIC ACID;6-bromo-1-(propan-2-yl)-1H-indazole-4-carboxylic acid;1H-Indazole-4-carboxylic acid, 6-bromo-1-(1-methylethyl)-
- CBNumber
- CB22705138
- Molecular Formula
- C11H11BrN2O2
- Formula Weight
- 283.12
- MOL File
- 1346702-54-2.mol
6-BROMO-1-ISOPROPYL-1H-INDAZOLE-4-CARBOXYLIC ACID Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B681320
- Product name
- 6-Bromo-1-isopropyl-1h-indazole-4-carboxylicAcid
- Packaging
- 50mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 1813AQ
- Product name
- 6-BROMO-1-ISOPROPYL-1H-INDAZOLE-4-CARBOXYLICACID
- Packaging
- 100mg
- Price
- $252.8
- Updated
- 2021/12/16
- Product number
- CD11290116
- Product name
- 6-Bromo-1-isopropyl-1H-indazole-4-carboxylicacid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $347
- Updated
- 2021/12/16
- Product number
- A319544
- Product name
- 6-Bromo-1-isopropyl-1H-indazole-4-carboxylicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $355
- Updated
- 2021/12/16
- Product number
- CM261250
- Product name
- 6-Bromo-1-isopropyl-1H-indazole-4-carboxylicacid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $425
- Updated
- 2021/12/16
6-BROMO-1-ISOPROPYL-1H-INDAZOLE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
1346702-52-0
1346702-54-2
b) Methyl 6-bromo-1-isopropyl-1H-indazole-4-carboxylate (0.58 g, 1.952 mmol) was dissolved in a solvent mixture of methanol (12 mL) and tetrahydrofuran (3 mL). A 3N NaOH solution (3.25 mL, 9.76 mmol) was added slowly via syringe and the reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the volatile solvent was removed under vacuum and the residue was diluted with water and the pH was adjusted to 4-5 by slow dropwise addition of 1 N HCl. The aqueous phase was extracted with a 20% THF/EtOAc solvent mixture (3 times). The organic phases were combined, washed with saturated brine, dried over anhydrous MgSO4, filtered and concentrated to afford 6-bromo-1-isopropyl-1H-indazole-4-carboxylic acid (0.52 g, 94% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6) and LC-MS (ES): 1H NMR δ 13.54 (s, 1H), 8.36-8.43 (m, 2H), 7.82 (d, J = 1.52 Hz, 1H), 5.11 (quin, J = 6.57 Hz, 1H), 1.48 (s, 3H), 1.47 ( s, 3H); LC-MS (ES) [M + H]+ 283.4/285.2.
References
[1] Patent: WO2011/140325, 2011, A1. Location in patent: Page/Page column 41
[2] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 12, p. 1091 - 1096
[3] Patent: WO2012/118812, 2012, A2. Location in patent: Page/Page column 320-321
6-BROMO-1-ISOPROPYL-1H-INDAZOLE-4-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
6-BROMO-1-ISOPROPYL-1H-INDAZOLE-4-CARBOXYLIC ACID Suppliers
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- India
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