SOLITHROMYCIN

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Product Name: SOLITHROMYCIN
CAS No.: 760981-83-7
Chemical Name: SOLITHROMYCIN
Synonyms: OP 1068;CEM 101;CS-1652;SOLITHROMYCIN;Solitthromycin;CEM-101;OP-1068;Solithromycin - CEM 101 | OP 1068;Solithromycin Solithromycin Solithromycin;2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 1-[4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl]-4-ethyl-7-fluorooctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-;(3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-(4-(4-(3-Aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone
CBNumber: CB22707354
Molecular Formula: C43H65FN6O10
Formula Weight: 845.01
MOL File: 760981-83-7.mol

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SOLITHROMYCIN Property

Boiling point:: 969.2±75.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: ≥34.35 mg/mL in DMSO
form: solid
pka: 13.46±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SBR00037
Product name: Solithromycin
Purity: ≥98% (HPLC)
Packaging: 10MG
Price: $69.4
Updated: 2024/03/01

Cayman Chemical

Product number: 21681
Product name: Solithromycin
Purity: ≥98%
Packaging: 5mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 21681
Product name: Solithromycin
Purity: ≥98%
Packaging: 10mg
Price: $65
Updated: 2024/03/01

Cayman Chemical

Product number: 21681
Product name: Solithromycin
Purity: ≥98%
Packaging: 25mg
Price: $127
Updated: 2024/03/01

ChemScene

Product number: CS-5053
Product name: Solithromycin
Purity: 99.97%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

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SOLITHROMYCIN Chemical Properties,Usage,Production

Pharmaceutical Applications

A 2-fluoroketolide. The side chain substituting the C11–C12 carbamate is composed of a substituted triazolyl (aminophenyl) ring. It displays good in-vitro and in-vivo activity against Streptococcus spp., including Str. pneumoniae (MIC 0.0015–0.25 mg/L), Str. pyogenes (MIC ≤0.008–0.015 mg/L)and viridians group streptococci (MIC ≤0.008–0.06 mg/L). Activity against H. influenzae is close to that of azithromycin (MIC 1.0–2.0 mg/L). Vancomycin-susceptible strains of E. faecalis are inhibited by 0.003–2.0 mg/L and E. faecium by 0.25–2.0 mg/L. It exhibits good activity against Ch. pneumoniae (MIC 0.25–1.0 mg/L), C. trachomatis (MIC 0.123–0.5 mg/L) and Mycoplasma spp. (MIC ≤0.0008 mg/L). In vitro H. pylori is susceptible (MIC 0.006–0.25 mg/L), but C. jejuni less so (MIC 1–4 mg/L). It is extremely active in vitro against B. anthracis (MIC <0.008–0.015 mg/L) and other agents of bioterrorism such as Francisella tularensis (MIC <0.08–4.0 mg/L), Yersinia pestis and Burkholderia mallei (MIC 0.25–2.0 mg/L). It exhibits a good activity against the M. avium complex.
In healthy adult volunteers the proposed therapeutic dose of 400 mg achieved a peak plasma concentration of 0.78 mg/L after 4 h. The apparent elimination half-life was 5.1 h.

Biological Activity

solithromycin (cem-101) is a new, potent and broad-spectrum fluoroketolide antibiotic [1][2].antibiotic is an antimicrobial used in the treatment and prevention of bacterial infection.solithromycin (cem-101) is a broad-spectrum fluoroketolide antibiotic. cem-101 exhibited high potency against diverse groups of gram-positive and gram-negative bacteria, including mycoplasma and ureaplasma, as well as bacteria associated with respiratory tract infections and skin infections, with mic50 values of 0.015 μg/ml and 4 μg/ml, respectively [1]. solithromycin (cem-101) bound to the large 50s subunit of the ribosome and inhibited protein biosynthesis. in streptococcus pneumoniae, staphylococcus aureus, and haemophilus influenzae, solithromycin inhibited cell viability, protein synthesis, and growth rate with ic50 values of 7.5, 40, and 125 ng/ml. solithromycin also inhibition the formation of the 50s subunit [3]. in monocytic u937 cells, solithromycin inhibited tnfα/cxcl8 production and mmp9 activity. in pbmc isolated from chronic obstructive pulmonary disease (copd) patients, solithromycin (10 μm) inhibited tnfα release and mmp9 activity. in monocytic u937 cells, solithromycin (10 μm) significantly inhibited nf-κb activity activated by oxidative stress [4].in c57bl/6j mice, solithromycin also inhibited cigarette smoke-induced neutrophilia and pro-mmp9 production [4]. cem-101 was also an effective antimicrobial for the prevention and treatment of intrauterine infection [2].

References

[1]. putnam sd, castanheira m, moet gj, et al. cem-101, a novel fluoroketolide: antimicrobial activity against a diverse collection of gram-positive and gram-negative bacteria. diagn microbiol infect dis, 2010, 66(4): 393-401.
[2]. keelan ja, kemp mw, payne ms, et al. maternal administration of solithromycin, a new, potent, broad-spectrum fluoroketolide antibiotic, achieves fetal and intra-amniotic antimicrobial protection in a pregnant sheep model. antimicrob agents chemother, 2014, 58(1): 447-454.
[3]. rodgers w, frazier ad, champney ws. solithromycin inhibition of protein synthesis and ribosome biogenesis in staphylococcus aureus, streptococcus pneumoniae, and haemophilus influenzae. antimicrob agents chemother, 2013, 57(4): 1632-1637.
[4]. kobayashi y, wada h, rossios c, et al. a novel macrolide solithromycin exerts superior anti-inflammatory effect via nf-κb inhibition. j pharmacol exp ther, 2013, 345(1): 76-84.

SOLITHROMYCIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from SOLITHROMYCIN manufacturers

shandong perfect biotechnology co.ltd

Product: Solithromycin 760981-83-7
Price: US $0.00/g
Min. Order: 1g
Purity: 98% HPLC
Supply Ability: 100kg
Release date: 2023-08-14

Handan Tongyi New Material Technology Co., Ltd

Product: Solithromycin Solithromycin Solithromycin 760981-83-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 500kg/month
Release date: 2021-03-10

hdzhl biotechnology co., ltd

Product: Solithromycin 760981-83-7
Price: US $0.00/Kg/Bag
Min. Order: 10g
Purity: 99%
Supply Ability: 1000 kg
Release date: 2019-09-18

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CEM 101

OP 1068

SOLITHROMYCIN

CEM-101;OP-1068

CS-1652

Solitthromycin

Solithromycin - CEM 101 | OP 1068

2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 1-[4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl]-4-ethyl-7-fluorooctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-

Solithromycin Solithromycin Solithromycin

(3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-(4-(4-(3-Aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone

760981-83-7

70981-83-7

C43H65FN6O10

Inhibitors