Description References
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LEE011

Description References
Product Name
LEE011
CAS No.
1256963-02-6
Chemical Name
LEE011
Synonyms
Rebosini;Ribociclib(LEE011);4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)pyrimidin-2-amine;LEE011;CS-842;CDK4-IN-1;CDK4 inhibitor;CDK4/6 inhibitor;LEE011 USP/EP/BP;Ribociclib Free Base
CBNumber
CB42655411
Molecular Formula
C22H29ClN8
Formula Weight
440.97
MOL File
1256963-02-6.mol
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LEE011 Property

Melting point:
>180°C (dec.)
Boiling point:
679.3±65.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
7.57±0.50(Predicted)
form 
Solid
color 
Beige
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C228130
Product name
CDK4/6Inhibitor
Packaging
25mg
Price
$1470
Updated
2021/12/16
Matrix Scientific
Product number
153615
Product name
4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)pyrimidin-2-amine
Purity
95%
Packaging
1g
Price
$1656
Updated
2021/12/16
Biorbyt Ltd
Product number
orb181278
Product name
Ribociclib (LEE011)
Purity
>99%
Packaging
1g
Price
$1802
Updated
2021/12/16
Biorbyt Ltd
Product number
orb546255
Product name
Ribociclib
Purity
>98%
Packaging
10mg
Price
$190.4
Updated
2021/12/16
Biorbyt Ltd
Product number
orb546255
Product name
Ribociclib
Purity
>98%
Packaging
50mg
Price
$430.1
Updated
2021/12/16
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LEE011 Chemical Properties,Usage,Production

Description

LEE011 (also known as ribociclib) is a CDK4/6 inhibitor. It has been recently approved by FDA (brand name: Kisqali®) to be combined with an aromatase inhibitor for initial endocrine-based therapy for treatment of postmenopausal women with hormone receptor positive, human epidermal growth factor receptor-2 negative (HR+/HER2-) advanced or metastatic breast cancer. It inhibits the growth of tumor cells by arresting the cells at the G1 checkpoint, which prevents the tumor cells from proliferating. In the phase III trial, it demonstrating statistically significant improvement in progression-free survival (PFS) compared to letrozole alone at the first pre-planned interim analysis. 

References

S. Kim et al. "Abstract PR02: LEE011: An orally bioavailable, selective small molecule inhibitor of CDK4/6- Reactivating Rb in cancer." Molecular Cancer Therapeutics 12.11_Supplement (2013):PR02-PR02.
Bardia, Aditya, et al. "Phase Ib/II study of LEE011, everolimus, and exemestane in postmenopausal women with ER+/HER2-metastatic breast cancer." Asco  2014.
https://www.novartis.com/news/media-releases/novartis-kisqalir-ribociclib-lee011-receives-fda-approval-first-line-treatment

Uses

CDK 4/6 Inhibitor is a part of a group of compounds that exhibits selective inhibitory properties towards Cyclin-Dependent Kinases 4 & 6. These compounds are most commonly used to treat patients with breast cancer.

LEE011 Preparation Products And Raw materials

Raw materials

Preparation Products

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LEE011 Suppliers

Shenzhen Yaoyuan R&D Center Co., Ltd
Tel
13421666688 13421666688
Email
664261110@qq.com
Country
China
ProdList
410
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
ExcelChemical (Shanghai) Chemical Technology Co., Ltd.
Tel
+86 13671938079
Fax
+86-021-50829787
Country
China
ProdList
39
Advantage
55
Jinan Mingya Medical Technology Co., Ltd.
Tel
0531-85828981
Fax
+86-531-85806006
Email
864598798@qq.com
Country
China
ProdList
588
Advantage
58
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb6@aikonchem.com
Country
China
ProdList
16684
Advantage
50
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
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View Lastest Price from LEE011 manufacturers

shandong perfect biotechnology co.ltd
Product
Ribociclib 1256963-02-6
Price
US $0.00/g
Min. Order
1g
Purity
98% HPLC
Supply Ability
1kg
Release date
2023-08-02
Dideu Industries Group Limited
Product
LEE011 1256963-02-6
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-01
Beijing Yibai Biotechnology Co., Ltd
Product
Ribociclib 1256963-02-6
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
99.0%
Supply Ability
5kg/month
Release date
2019-08-27

1256963-02-6, LEE011Related Search:


  • Rebosini
  • LEE011
  • CDK4/6 inhibitor
  • CDK4 inhibitor
  • CDK4-IN-1
  • CS-842
  • 4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)pyrimidin-2-amine
  • CDK 4/6 Inhibitor, >=98%
  • Ribociclib(LEE011)
  • Ribociclib(Lee011 & CDK 4/6 inhibitor)
  • 4-[5-Chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-2-pyrimidinamine
  • 4-(3-chloro-5-propan-2-yl-1H-pyrazol-4-yl)-N-[5-[4-(dimethylamino)piperidin-1-yl]pyridin-2-yl]pyrimidin-2-amine
  • Ribociclib Free Base
  • 4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)py
  • 2-Pyrimidinamine, 4-[3-chloro-5-(1-methylethyl)-1H-pyrazol-4-yl]-N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-
  • LEE011 USP/EP/BP
  • 1256963-02-6
  • C22H29ClN8
  • Inhibitors