ChemicalBook > CAS DataBase List > EAI-045

EAI-045

Product Name
EAI-045
CAS No.
1942114-09-1
Chemical Name
EAI-045
Synonyms
EA1045;EAI-045;CS-2350;EAI 045;EAI-045;EAI045;EAI 045;EAI-045;2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide;α-(5-fluoro-2-hydroxyphenyl)-1,3-dihydro-1-oxo-N-2-thiazolyl-2H-Isoindole-2-acetamide;2H-Isoindole-2-acetamide,α-(5-fluoro-2-hydroxyphenyl)-1,3-dihydro-1-oxo-N-2-thiazolyl-;N-(3-((5-fluoroethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide (EAI-045);2H-Isoindole-2-acetamide, α-(5-fluoro-2-hydroxyphenyl)-1,3-dihydro-1-oxo-N-2-thiazolyl-
CBNumber
CB83122752
Molecular Formula
C19H14FN3O3S
Formula Weight
383.4
MOL File
1942114-09-1.mol
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EAI-045 Property

Density 
1.546±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
pka
7.20±0.50(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19719
Product name
EAI045
Purity
≥98%
Packaging
1mg
Price
$30
Updated
2021/03/22
Cayman Chemical
Product number
19719
Product name
EAI045
Purity
≥98%
Packaging
5mg
Price
$135
Updated
2021/03/22
Cayman Chemical
Product number
19719
Product name
EAI045
Purity
≥98%
Packaging
10mg
Price
$225
Updated
2021/03/22
Cayman Chemical
Product number
19719
Product name
EAI045
Purity
≥98%
Packaging
25mg
Price
$488
Updated
2021/03/22
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EAI-045 Chemical Properties,Usage,Production

Description

EAI045 is a potent and selective EGFR inhibitor (fourth generation). EAI045 targets selected drug-resistant EGFR mutants without affecting the wild-type receptor. EAI045 inhibits L858R/T790M-mutant EGFR with low-nanomolar potency in biochemical assays. Therefore, it is a potential candidate drug for the treatment of related non-small cell lung cancer (NSCLC). It should be noted that EAI-045 is effectively in targeting the EGFR C797S mutation, which is resistance to the third-generation EGFR inhibitors including AZD9291 (osimertinib) and CO-1686 (rociletinib).

References

Wang, S., Y. Song, and D. Liu. "EAI045: The fourth-generation EGFR inhibitor overcoming T790M and C797S resistance." Cancer Letters385(2017):51.
Jia, Y., et al. "Overcoming EGFR T790M and C797S resistance with mutant-selective allosteric inhibitors:." Nature 534.7605(2016):129.

EAI-045 Preparation Products And Raw materials

Raw materials

Preparation Products

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EAI-045 Suppliers

Lydow(Shanghai)Chemical Co.,Ltd
Tel
21-33758180-
Fax
+86-21-51685790
Email
Joseph@novapharmas.com
Country
China
ProdList
505
Advantage
55
Wuhu Sumu Pharmaceutical Technology Co., Ltd.
Fax
-
Email
3145613242@qq.com
Country
China
ProdList
36
Advantage
58
Easycom Pharma Limited
Tel
QQ 1503941778
Email
info@easycompharma.com
Country
China
ProdList
20
Advantage
58
Hubei Junxian Biotechnology Co., Ltd
Email
3464928989@qq.com
Country
China
ProdList
46
Advantage
58
Chunchuang (Wuhan) Technology Co., Ltd
Tel
Email
yutianchun2007@126.com
Country
China
ProdList
9973
Advantage
58
Xuzhou zuncheng chemical technology co. LTD
Tel
Email
451247499@qq.com
Country
China
ProdList
34
Advantage
58
Ningbo Risheng Pharmaceutical Technology Co., Ltd.
Tel
Fax
0574-89132888
Email
2928184953@qq.com
Country
China
ProdList
47
Advantage
58
Shandong Chenxi Pharmaceutical Co., Ltd.
Tel
0531-88803416-
Fax
0531-88803416
Email
sales@chemedpharma.com;
Country
China
ProdList
171
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2926
Advantage
55
Wuhan Sunrise Technology Development Co., Ltd.
Tel
027-83314682
Fax
+86 (27) 8331-4682
Email
whsrtech@vip.163.com;whsrtech@vip.163.com
Country
China
ProdList
280
Advantage
62
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View Lastest Price from EAI-045 manufacturers

Career Henan Chemical Co
Product
EAI-045 1942114-09-1
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-08

1942114-09-1, EAI-045Related Search:


  • EAI-045
  • 2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide
  • EA1045
  • α-(5-fluoro-2-hydroxyphenyl)-1,3-dihydro-1-oxo-N-2-thiazolyl-2H-Isoindole-2-acetamide
  • EAI 045;EAI-045
  • CS-2350
  • EAI045;EAI 045;EAI-045
  • N-(3-((5-fluoroethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide (EAI-045)
  • 2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-1,3-thiazol-2-ylacetamide
  • 2H-Isoindole-2-acetamide, α-(5-fluoro-2-hydroxyphenyl)-1,3-dihydro-1-oxo-N-2-thiazolyl-
  • 2H-Isoindole-2-acetamide,α-(5-fluoro-2-hydroxyphenyl)-1,3-dihydro-1-oxo-N-2-thiazolyl-
  • 1942114-09-1
  • C19H14FN3O3S
  • API
  • API