LEE011

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Description References

Product Name: LEE011
CAS No.: 1256963-02-6
Chemical Name: LEE011
Synonyms: Rebosini;Ribociclib(LEE011);4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)pyrimidin-2-amine;LEE011;CS-842;CDK4-IN-1;CDK4 inhibitor;CDK4/6 inhibitor;LEE011 USP/EP/BP;Ribociclib Free Base
CBNumber: CB42655411
Molecular Formula: C22H29ClN8
Formula Weight: 440.97
MOL File: 1256963-02-6.mol

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LEE011 Property

Melting point:: >180°C (dec.)
Boiling point:: 679.3±65.0 °C(Predicted)
Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 7.57±0.50(Predicted)
form: Solid
color: Beige

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C228130
Product name: CDK4/6Inhibitor
Packaging: 25mg
Price: $1470
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb546255
Product name: Ribociclib
Purity: >98%
Packaging: 10mg
Price: $190.4
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb546255
Product name: Ribociclib
Purity: >98%
Packaging: 50mg
Price: $430.1
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb181278
Product name: Ribociclib (LEE011)
Purity: >99%
Packaging: 100mg
Price: $606.9
Updated: 2021/12/16

Matrix Scientific

Product number: 153615
Product name: 4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)pyrimidin-2-amine
Purity: 95%
Packaging: 250mg
Price: $740
Updated: 2021/12/16

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LEE011 Chemical Properties,Usage,Production

Description

LEE011 (also known as ribociclib) is a CDK4/6 inhibitor. It has been recently approved by FDA (brand name: Kisqali®) to be combined with an aromatase inhibitor for initial endocrine-based therapy for treatment of postmenopausal women with hormone receptor positive, human epidermal growth factor receptor-2 negative (HR+/HER2-) advanced or metastatic breast cancer. It inhibits the growth of tumor cells by arresting the cells at the G1 checkpoint, which prevents the tumor cells from proliferating. In the phase III trial, it demonstrating statistically significant improvement in progression-free survival (PFS) compared to letrozole alone at the first pre-planned interim analysis.

References

S. Kim et al. "Abstract PR02: LEE011: An orally bioavailable, selective small molecule inhibitor of CDK4/6- Reactivating Rb in cancer." Molecular Cancer Therapeutics 12.11_Supplement (2013):PR02-PR02.
Bardia, Aditya, et al. "Phase Ib/II study of LEE011, everolimus, and exemestane in postmenopausal women with ER+/HER2-metastatic breast cancer." Asco 2014.
https://www.novartis.com/news/media-releases/novartis-kisqalir-ribociclib-lee011-receives-fda-approval-first-line-treatment

Uses

CDK 4/6 Inhibitor is a part of a group of compounds that exhibits selective inhibitory properties towards Cyclin-Dependent Kinases 4 & 6. These compounds are most commonly used to treat patients with breast cancer.

LEE011 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from LEE011 manufacturers

shandong perfect biotechnology co.ltd

Product: Ribociclib 1256963-02-6
Price: US $0.00/g
Min. Order: 1g
Purity: 98% HPLC
Supply Ability: 1kg
Release date: 2023-08-02

Dideu Industries Group Limited

Product: LEE011 1256963-02-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-01

Beijing Yibai Biotechnology Co., Ltd

Product: Ribociclib 1256963-02-6
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 99.0%
Supply Ability: 5kg/month
Release date: 2019-08-27

1256963-02-6, LEE011Related Search:

PLX4032 Alectinib Hydrochloride Nintedanib Ethanesulfonate Salt Olaparib EAI-045 Nintedanib PLX-4720 Alectinib Crizotinib Afatinib (BIBW 2992) PLERIXAFOR Neratinib Ripasudil hydrochloride dihydrate Cabozantinib Malate Riociguat 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile 1110813-31-4 918504-65-1

Rebosini

LEE011

CDK4/6 inhibitor

CDK4 inhibitor

CDK4-IN-1

CS-842

4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)pyrimidin-2-amine

CDK 4/6 Inhibitor, >=98%

Ribociclib(LEE011)

Ribociclib(Lee011 & CDK 4/6 inhibitor)

4-[5-Chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-2-pyrimidinamine

4-(3-chloro-5-propan-2-yl-1H-pyrazol-4-yl)-N-[5-[4-(dimethylamino)piperidin-1-yl]pyridin-2-yl]pyrimidin-2-amine

Ribociclib Free Base

4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)py

2-Pyrimidinamine, 4-[3-chloro-5-(1-methylethyl)-1H-pyrazol-4-yl]-N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-

LEE011 USP/EP/BP

1256963-02-6

C22H29ClN8

Inhibitors