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Tosufloxacin p-Toluenesulfonate Hydrate

Product Name
Tosufloxacin p-Toluenesulfonate Hydrate
CAS No.
1400591-39-0
Chemical Name
Tosufloxacin p-Toluenesulfonate Hydrate
Synonyms
T-3262 Tosylate Hydrate;A-61827 tosylate hydrate;Tosufloxacin (tosylate hydrate);Tosufloxacin tosylate hydrate, 10 mM in DMSO;Tosufloxacin tosylate hydrate (T3262, A61827);Tosufloxacin p-Toluenesulfonate Hydrate;Tosufloxacin toluenesulfonate hydrate - Bio-X ?;1,8-Naphthyridine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, 4-methylbenzenesulfonate, hydrate (1:1:)
CBNumber
CB22709949
Molecular Formula
C26H23F3N4O6S
Formula Weight
576.55
MOL File
1400591-39-0.mol
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Tosufloxacin p-Toluenesulfonate Hydrate Property

storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 33 mg/mL (55.50 mM)
form 
Solid
color 
White to off-white
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Safety

RTECS 
QN2791000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
T2506
Product name
Tosufloxacin p-Toluenesulfonate Hydrate
Purity
>98.0%(HPLC)
Packaging
5g
Price
$151
Updated
2021/12/16
Chem-Impex
Product number
38451
Product name
Tosufloxacinp-toluenesulfonatehydrate,98%(HPLC)
Purity
98%(HPLC)
Packaging
5G
Price
$165.76
Updated
2021/12/16
ChemScene
Product number
CS-5713
Product name
Tosufloxacin(tosylatehydrate)
Purity
99.17%
Packaging
5g
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-5713
Product name
Tosufloxacin(tosylatehydrate)
Purity
99.17%
Packaging
10g
Price
$240
Updated
2021/12/16
ChemScene
Product number
CS-5713
Product name
Tosufloxacin(tosylatehydrate)
Purity
99.17%
Packaging
200mg
Price
$60
Updated
2021/12/16
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Tosufloxacin p-Toluenesulfonate Hydrate Chemical Properties,Usage,Production

Uses

Tosufloxacin tosylate hydrate (A-61827) is an orally active fluoroquinolone antibiotic. Tosufloxacin shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria[1][2].

Definition

ChEBI: A racemate comprising equimolar amounts of (R)- and (S)-tosufloxacin tosylate hydrate.

in vivo

Tosufloxacin tosylate hydrate (T-3262) (oral gavage; 0.16-13.39 mg/kg; once) treatment shows antibacterial activity against S. aureus, E. coli, and P. aeruginosa in vivo[2].

Animal Model:Male Slc:ICR mice infected with S. aureus[2]
Dosage:1.27-2.15 mg/kg
Administration:Oral gavage; 1.27-2.15 mg/kg; once
Result:Showed 50% effective dose (ED50) of 1.62 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.0125 μg/mL.
Animal Model:Male Slc:ICR mice infected with E. coli[2]
Dosage:0.16-0.30 mg/kg
Administration:Oral gavage; 0.16-0.30 mg/kg; once
Result:Showed 50% effective dose (ED50) of 0.22 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.0125 μg/mL.
Animal Model:Male Slc:ICR mice infected with P. aeruginosa[2]
Dosage:7.66-13.39 mg/kg
Administration:Oral gavage; 7.66-13.39 mg/kg; once
Result:Showed 50% effective dose (ED50) of 10.13 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.78 μg/mL.

IC 50

Quinolone

References

[1] Chu DT, et al. Synthesis and biological properties of A-71497: a prodrug of tosufloxacin. Drugs Exp Clin Res. 1990;16(9):435-43. PMID:2100244
[2] Fujimaki K, et al. In vitro and in vivo antibacterial activities of T-3262, a new fluoroquinolone. Antimicrob Agents Chemother. 1988 Jun;32(6):827-33. DOI:10.1128/AAC.32.6.827

Tosufloxacin p-Toluenesulfonate Hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Tosufloxacin p-Toluenesulfonate Hydrate Suppliers

China 36 United States 7 Global 43
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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Alta Scientific Co., Ltd.
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022-6537-8550 15522853686
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022-2532-9655
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sales@altasci.com.cn
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Shanghai YuanYe Biotechnology Co., Ltd.
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Musechem
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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+86-400-002-6226 +86-13028896684;
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sales@rrkchem.com
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TCI Chemicals
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021-67121386, 800-988-0390
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Sales-CN@TCIchemicals.com
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Jiangsu aikang biomedical research and development co., LTD
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025-58859352 13155353615
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1400591-39-0, Tosufloxacin p-Toluenesulfonate HydrateRelated Search:


  • Tosufloxacin (tosylate hydrate)
  • Tosufloxacin <i>p</i>-Toluenesulfonate Hydrate
  • 1,8-Naphthyridine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, 4-methylbenzenesulfonate, hydrate (1:1:)
  • A-61827 tosylate hydrate
  • T-3262 Tosylate Hydrate
  • Tosufloxacin tosylate hydrate (T3262, A61827)
  • Tosufloxacin tosylate hydrate, 10 mM in DMSO
  • Tosufloxacin toluenesulfonate hydrate - Bio-X ?
  • 1400591-39-0