AR7
- Product Name
- AR7
- CAS No.
- 80306-38-3
- Chemical Name
- AR7
- Synonyms
- AR7;ERBA;ERB-T-1;CS-2649;c-ERBA-1;MGC43240;AR7;AR 7;MGC000261;AR 7(RARα agonist);Atypical retinoid 7
- CBNumber
- CB22714659
- Molecular Formula
- C15H12ClNO
- Formula Weight
- 257.71
- MOL File
- 80306-38-3.mol
AR7 Property
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- color
- white to beige
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
N-Bromosuccinimide Price
- Product number
- SRP2127
- Product name
- TR, α1, GST tagged human
- Purity
- recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
- Packaging
- 10μG
- Price
- $400
- Updated
- 2024/03/01
- Product number
- SML0921
- Product name
- AR7
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $118
- Updated
- 2024/03/01
- Product number
- SRP2046
- Product name
- Thyroid Hormone receptor,α1 human
- Purity
- recombinant, expressed in insect cells, ≥80% (SDS-PAGE)
- Packaging
- 5μG
- Price
- $471
- Updated
- 2024/03/01
- Product number
- SML0921
- Product name
- AR7
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $478
- Updated
- 2024/03/01
- Product number
- 22946
- Product name
- AR-7
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
AR7 Chemical Properties,Usage,Production
Description
AR7 (80306-38-3) is an atypical retinoid which acts as an RARα antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pathway.1 Downstream signaling results in an increase of LAMP-2A expression.1 Cells pretreated with AR7 had markedly improved viability in a paraquat-induced oxidative stress model.1 AR7 stimulated CMA and attenuated accumulation of SNCA oligomers in prolonged cultures of mutant cortical neurons2 indicating that CMA activation may be a viable disease modifying strategy in Parkinson’s disease3. A targetome analysis of AR7-induced CMA in cancer cells has been performed.4
Uses
AR 7 is a CMA booster. Used in biological study of chemical modulation of chaperone-?mediated autophagy by retinoic acid derivatives.
References
Anguiano et al. (2013), Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives; Nat. Chem. Biol. 9 374 Ho et al. (2020), Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA); Autophagy 16 347 Bonam et al. (2021), Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease; Cells 10 3547 Hao et al. (2019), Targetome analysis of chaperone-mediated autophagy in cancer cells; Autophagy 15 1558
AR7 Preparation Products And Raw materials
Raw materials
Preparation Products
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