AR7
- Product Name
- AR7
- CAS No.
- 80306-38-3
- Chemical Name
- AR7
- Synonyms
- AR7;ERBA;CHNG6;THRA2;ERB-T-1;CS-2649;c-ERBA-1;MGC43240;AR7;AR 7;MGC000261
- CBNumber
- CB22714659
- Molecular Formula
- C15H12ClNO
- Formula Weight
- 257.71
- MOL File
- 80306-38-3.mol
AR7 Property
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- color
- white to beige
- biological source
- human
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
N-Bromosuccinimide Price
- Product number
- SRP2127
- Product name
- TR, α1, GST tagged human
- Purity
- recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
- Packaging
- 10μG
- Price
- $310
- Updated
- 2025/07/31
- Product number
- SRP2046
- Product name
- Thyroid Hormone receptor,α1 human
- Purity
- recombinant, expressed in insect cells, ≥80% (SDS-PAGE)
- Packaging
- 5μG
- Price
- $413
- Updated
- 2025/07/31
- Product number
- SML0921
- Product name
- AR7
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $121
- Updated
- 2025/07/31
- Product number
- SML0921
- Product name
- AR7
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $491
- Updated
- 2025/07/31
- Product number
- 22946
- Product name
- AR-7
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
AR7 Chemical Properties,Usage,Production
Description
AR7 (80306-38-3) is an atypical retinoid which acts as an RARα antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pathway.1 Downstream signaling results in an increase of LAMP-2A expression.1 Cells pretreated with AR7 had markedly improved viability in a paraquat-induced oxidative stress model.1 AR7 stimulated CMA and attenuated accumulation of SNCA oligomers in prolonged cultures of mutant cortical neurons2 indicating that CMA activation may be a viable disease modifying strategy in Parkinson’s disease3. A targetome analysis of AR7-induced CMA in cancer cells has been performed.4
Uses
AR 7 is a CMA booster. Used in biological study of chemical modulation of chaperone-?mediated autophagy by retinoic acid derivatives.
References
[1] JAIME ANGUIANO. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives[J]. Nature chemical biology, 2013, 9 6: 374-382. DOI:10.1038/nchembio.1230
[2] PHILIP WING-LOK HO. Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA).[J]. Autophagy, 2020, 16 2: 347-370. DOI:10.1080/15548627.2019.1603545
[3] SRINIVASA REDDY BONAM Sylviane M Christine Tranchant. Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease.[J]. ACS Applied Materials & Interfaces, 2021. DOI:10.3390/cells10123547
[4] YUQING HAO. Targetome analysis of chaperone-mediated autophagy in cancer cells.[J]. Autophagy, 2019: 1558-1571. DOI:10.1080/15548627.2019.1586255
AR7 Preparation Products And Raw materials
Raw materials
Preparation Products
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