ChemicalBook > CAS DataBase List > Cilliobrevin D
Cilliobrevin D
- Product Name
- Cilliobrevin D
- CAS No.
- 1370554-01-0
- Chemical Name
- Cilliobrevin D
- Synonyms
- Cilliobrevin D;Ciliobrevin D, 10 mM in DMSO;Cytoplasmic Dynein Inhibitor, Ciliobrevin D;Benzenepropanenitrile, 2,4-dichloro-α-(7-chloro-3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-β-oxo-;2-(7-Chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile;inhibit,melanosome,spindles,cytoplasmic,γ-tubulin,Inhibitor,dynein,ATPases,Ciliobrevin D,Hedgehog,peroxisomes,aggregation
- CBNumber
- CB22714664
- Molecular Formula
- C17H8Cl3N3O2
- Formula Weight
- 392.62
- MOL File
- 1370554-01-0.mol
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Cilliobrevin D Property
- Boiling point:
- 591.8±50.0 °C(Predicted)
- Density
- 1.537±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 5 mg/mL (12.73 mM; ultrasonic and warming and heat to 80°C)
- pka
- 5.99±0.20(Predicted)
- form
- Solid
- color
- Light yellow to yellow
- InChI
- InChI=1S/C17H8Cl3N3O2/c18-8-1-3-10(13(20)5-8)15(24)12(7-21)16-22-14-6-9(19)2-4-11(14)17(25)23-16/h1-6,22H,(H,23,25)
- InChIKey
- JKKSCGHDRHRWOQ-UHFFFAOYSA-N
- SMILES
- C(=C1NC(=O)C2=CC=C(Cl)C=C2N1)(C#N)C(C1C=CC(Cl)=CC=1Cl)=O
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 250401
- Product name
- Cytoplasmic Dynein Inhibitor, Ciliobrevin D
- Purity
- Ciliobrevin D is a cell-permeable, reversible, and specific blocker of AAA+ ATPase motor cytoplasmic dynein. Disrupts spindle pole focusing and kinetochore-microtubule attachment (~10 to 40 µM).
- Packaging
- 10 mg
- Price
- $252
- Updated
- 2025/07/31
TRC
- Product number
- C441315
- Product name
- CiliobrevinD
- Packaging
- 25mg
- Price
- $1260
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0087674
- Product name
- CiliobrevinD
- Purity
- 98.94%
- Packaging
- 50mg
- Price
- $1950
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0087674
- Product name
- CiliobrevinD
- Purity
- 98.94%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0087674
- Product name
- CiliobrevinD
- Purity
- 98.94%
- Packaging
- 10mg
- Price
- $595
- Updated
- 2021/12/16
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Cilliobrevin D Chemical Properties,Usage,Production
Uses
Ciliobrevin D is an inhibitor of the AAA+ ATPase motor cytoplasmic dynein.
in vivo
Knockdown of Dync1h1 or inactivation of dynein 1 by Ciliobrevin D in the testis in vivo perturbs spermatogenesis. Knockdown of Dync1h1 or the use of Ciliobrevin D to inactivate dynein 1 in the testis in vivo perturbs MT organization through changes in the spatial expression of EB1, perturbs F-actin organization, and perturbs distribution of adhesion protein complexes at the BTB, leading to a loss of BTB integrity. F-actin disorganization in the seminiferous epithelium following Dync1h1 knockdown or dynein 1 inactivation by Ciliobrevin D is mediated by changes in the spatiotemporal expression of actin regulatory proteins Arp3 and Eps8[3].
Cilliobrevin D Preparation Products And Raw materials
Raw materials
Preparation Products
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