ChemicalBook > CAS DataBase List > 4SC-202 (free base)

4SC-202 (free base)

Product Name: 4SC-202 (free base)
CAS No.: 910462-43-0
Chemical Name: 4SC-202 (free base)
Synonyms: CS-1285;Domatinostat;domatinostat HCl;4SC-202 (free base);Domatinostat (4SC202);Domatinostat, 10 mM in DMSO;HDAC,Domatinostat,Apoptosis,inhibit,Inhibitor,Histone deacetylases;(E)-N-(2-aminophenyl)-3-(1-(4-(1-methyl-1H-pyrazol-4-yl)phenylsulfonyl)-1H-pyrrol-3-yl)acrylamide;(2E)-N-(2-Aminophenyl)-3-[1-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]sulfonyl]-1H-pyrrol-3-yl]-2-propenamide;2-Propenamide, N-(2-aminophenyl)-3-[1-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]sulfonyl]-1H-pyrrol-3-yl]-, (2E)-
CBNumber: CB22715601
Molecular Formula: C23H21N5O3S
Formula Weight: 447.51
MOL File: 910462-43-0.mol

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4SC-202 (free base) Property

Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: ≥ 58 mg/mL (129.61 mM)
form: Solid
pka: 12.60±0.70(Predicted)
color: White to khaki

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-3275
Product name: Domatinostat
Purity: 99.08%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-3275
Product name: Domatinostat
Purity: 99.08%
Packaging: 10mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-3275
Product name: Domatinostat
Purity: 99.08%
Packaging: 50mg
Price: $540
Updated: 2021/12/16

ChemScene

Product number: CS-3275
Product name: Domatinostat
Purity: 99.08%
Packaging: 100mg
Price: $1020
Updated: 2021/12/16

DC Chemicals

Product number: DC8423
Product name: 4SC-202freebase
Purity: >98%
Packaging: 1g
Price: $1800
Updated: 2021/12/16

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4SC-202 (free base) Chemical Properties,Usage,Production

Uses

4SC-202 acts as a selective and potent, orallly available inhibitor of histone deacetylases (HDAC) specific for class 1 HDAC isoenzymes with an IC50 value.

in vivo

Oral gavage of Domatinostat (4SC-202 free base) inhibits HT-29 xenograft growth in nude mice, and when combined with oxaliplatin, its activity is further strengthened^[2].

IC 50

HDAC-3: 0.57 μM (IC₅₀); HDAC-2: 1.12 μM (IC₅₀); HDAC-1: 1.2 μM (IC₅₀); HDAC-11: 9.7 μM (IC₅₀); HDAC-5: 11.3 μM (IC₅₀); HDAC-10: 21 μM (IC₅₀); HDAC-9: 50 μM (IC₅₀)

4SC-202 (free base) Preparation Products And Raw materials

Raw materials

Preparation Products

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910462-43-0, 4SC-202 (free base)Related Search:

FORMANILIDE 4-Aminodiphenylamine

4SC-202 (free base)

(E)-N-(2-aminophenyl)-3-(1-(4-(1-methyl-1H-pyrazol-4-yl)phenylsulfonyl)-1H-pyrrol-3-yl)acrylamide

(2E)-N-(2-Aminophenyl)-3-[1-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]sulfonyl]-1H-pyrrol-3-yl]-2-propenamide

CS-1285

2-Propenamide, N-(2-aminophenyl)-3-[1-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]sulfonyl]-1H-pyrrol-3-yl]-, (2E)-

Domatinostat

domatinostat HCl

Domatinostat (4SC202)

HDAC,Domatinostat,Apoptosis,inhibit,Inhibitor,Histone deacetylases

Domatinostat, 10 mM in DMSO

910462-43-0

Inhibitors