CPI-169

Product Name: CPI-169
CAS No.: 1450655-76-1
Chemical Name: CPI-169
Synonyms: CPI-169;CPI 169;CPI169;CPI-169 racemate;CPI169;CPI 169;CPI-169;CPI-169, EZH2 inhibitor;CPI169 racemate,CPI 169 racemate;1-(1-(1-(Ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide;1H-Indole-3-carboxamide, N-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-1-[1-[1-(ethylsulfonyl)-4-piperidinyl]ethyl]-2-methyl-
CBNumber: CB22715621
Molecular Formula: C27H36N4O5S
Formula Weight: 528.66
MOL File: 1450655-76-1.mol

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CPI-169 Property

Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥26.45 mg/mL in DMSO; insoluble in H2O; ≥2.18 mg/mL in EtOH with gentle warming and ultrasonic
form: solid
pka: 11.01±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Signal word: Warning

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18299
Product name: CPI-169
Purity: ≥98%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 18299
Product name: CPI-169
Purity: ≥98%
Packaging: 5mg
Price: $235
Updated: 2024/03/01

TRC

Product number: C781428
Product name: CPI-169
Packaging: 25mg
Price: $800
Updated: 2021/12/16

ChemScene

Product number: CS-3137
Product name: CPI-169racemate
Purity: 98.52%
Packaging: 50mg
Price: $816
Updated: 2021/12/16

ChemScene

Product number: CS-3137
Product name: CPI-169racemate
Purity: 98.52%
Packaging: 100mg
Price: $1320
Updated: 2021/12/16

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CPI-169 Chemical Properties,Usage,Production

Uses

CPI-169 is a heteroaryl amide that was discovered useful as modulator of Me modifying enzymes.

Definition

ChEBI: 1-[1-(1-ethylsulfonyl-4-piperidinyl)ethyl]-N-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-3-indolecarboxamide is an indolecarboxamide.

Biological Activity

cpi-169 is a novel, small molecule and potent inhibitor of enhancer of zeste homolog 2 (ezh2) with an ic50 value of <1nm for polycomb repressive complex 2 (prc2) [1].cpi-169 has been found to be a potent ezh2 inhibitor with an ic50 value of <1nm for polycomb repressive complex 2 (prc2). in addition, cpi-169 has been reported to reduce cellular levels of histone h3 on lysine 27(h3k27) with an ec50 value of 70nm. moreover, cpi-169 has been exhibited to trigger cell cycle arrest and apoptosis in cells. apart from these, treatment the inhibitor at 200mpk twice daily, cpi-169 has been noted to have a well tolerated in mice with no observed toxic effect or body weight loss [1].

References

[1] vidya balasubramanian, priya iyer, shilpi arora, patrick troyer, emmanuel normant. constellation pharmaceuticals, cambridge, ma. cpi-169, a novel and potent ezh2 inhibitor, synergizes with chop in vivo and achieves complete regression in lymphoma xenograft models

CPI-169 Preparation Products And Raw materials

Raw materials

Preparation Products

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CPI-169 Suppliers

China 54 United States 10 Global 64

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7887
Advantage: 56

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4573
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 1004
Advantage: 55

SPIRO PHARMA

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Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

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View Lastest Price from CPI-169 manufacturers

Career Henan Chemical Co

Product: 1-(1-(1-(ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2- methyl-1H-indole-3-carboxamide 1450655-76-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

1450655-76-1, CPI-169Related Search:

CPI-169

CPI-169 racemate

1-(1-(1-(Ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide

1H-Indole-3-carboxamide, N-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-1-[1-[1-(ethylsulfonyl)-4-piperidinyl]ethyl]-2-methyl-

CPI169;CPI 169;CPI-169

CPI 169;CPI169

CPI169 racemate,CPI 169 racemate

CPI-169, EZH2 inhibitor

1450655-76-1