CPI-169

Product Name: CPI-169
CAS No.: 1450655-76-1
Chemical Name: CPI-169
Synonyms: CPI-169;CPI 169;CPI169;CPI-169 racemate;CPI169;CPI 169;CPI-169;CPI-169, EZH2 inhibitor;CPI169 racemate,CPI 169 racemate;1-(1-(1-(Ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide;1H-Indole-3-carboxamide, N-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-1-[1-[1-(ethylsulfonyl)-4-piperidinyl]ethyl]-2-methyl-
CBNumber: CB22715621
Molecular Formula: C27H36N4O5S
Formula Weight: 528.66
MOL File: 1450655-76-1.mol

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CPI-169 Property

Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥26.45 mg/mL in DMSO; insoluble in H2O; ≥2.18 mg/mL in EtOH with gentle warming and ultrasonic
form: solid
pka: 11.01±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Signal word: Warning

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18299
Product name: CPI-169
Purity: ≥98%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 18299
Product name: CPI-169
Purity: ≥98%
Packaging: 5mg
Price: $235
Updated: 2024/03/01

TRC

Product number: C781428
Product name: CPI-169
Packaging: 25mg
Price: $800
Updated: 2021/12/16

ChemScene

Product number: CS-3137
Product name: CPI-169racemate
Purity: 98.52%
Packaging: 5mg
Price: $144
Updated: 2021/12/16

ChemScene

Product number: CS-3137
Product name: CPI-169racemate
Purity: 98.52%
Packaging: 10mg
Price: $216
Updated: 2021/12/16

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CPI-169 Chemical Properties,Usage,Production

Uses

CPI-169 is a heteroaryl amide that was discovered useful as modulator of Me modifying enzymes.

Definition

ChEBI: 1-[1-(1-ethylsulfonyl-4-piperidinyl)ethyl]-N-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-3-indolecarboxamide is an indolecarboxamide.

Biological Activity

cpi-169 is a novel, small molecule and potent inhibitor of enhancer of zeste homolog 2 (ezh2) with an ic50 value of <1nm for polycomb repressive complex 2 (prc2) [1].cpi-169 has been found to be a potent ezh2 inhibitor with an ic50 value of <1nm for polycomb repressive complex 2 (prc2). in addition, cpi-169 has been reported to reduce cellular levels of histone h3 on lysine 27(h3k27) with an ec50 value of 70nm. moreover, cpi-169 has been exhibited to trigger cell cycle arrest and apoptosis in cells. apart from these, treatment the inhibitor at 200mpk twice daily, cpi-169 has been noted to have a well tolerated in mice with no observed toxic effect or body weight loss [1].

References

[1] vidya balasubramanian, priya iyer, shilpi arora, patrick troyer, emmanuel normant. constellation pharmaceuticals, cambridge, ma. cpi-169, a novel and potent ezh2 inhibitor, synergizes with chop in vivo and achieves complete regression in lymphoma xenograft models

CPI-169 Preparation Products And Raw materials

Raw materials

Preparation Products

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CPI-169 Suppliers

China 54 United States 10 Global 64

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

ApexBio Technology

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Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Abcam

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Email: us.orders@abcam.com
Country: United States
ProdList: 6000
Advantage: 50

Cayman Chemical Company

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Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

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Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

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View Lastest Price from CPI-169 manufacturers

Career Henan Chemical Co

Product: 1-(1-(1-(ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2- methyl-1H-indole-3-carboxamide 1450655-76-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

1450655-76-1, CPI-169Related Search:

CPI-169

CPI-169 racemate

1-(1-(1-(Ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide

1H-Indole-3-carboxamide, N-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-1-[1-[1-(ethylsulfonyl)-4-piperidinyl]ethyl]-2-methyl-

CPI169;CPI 169;CPI-169

CPI 169;CPI169

CPI169 racemate,CPI 169 racemate

CPI-169, EZH2 inhibitor

1450655-76-1