ChemicalBook > CAS DataBase List > 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE

1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE

Product Name
1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE
CAS No.
517918-95-5
Chemical Name
1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE
Synonyms
5-CYANO-7-AZAINDOLE;7-Azaindole-5-carbonitrile;7-Azaindole-5-carbonitrile,97%;5-canyo-1H-Pyrrolo[2,3-b]pyridine;5-Cyano-1H-pyrrolo[2,3-b]pyridine;1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE;1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile(9CI);1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE ISO 9001：2015 REACH;7-Azaindole-5-carbonitrile,1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile
CBNumber
CB2271691
Molecular Formula
C8H5N3
Formula Weight
143.15
MOL File
517918-95-5.mol
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1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE Property

Melting point:
225.1-225.2°C
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
solid
pka
12.50±0.40(Predicted)
Appearance
Off-white to light brown Solid
InChI
InChI=1S/C8H5N3/c9-4-6-3-7-1-2-10-8(7)11-5-6/h1-3,5H,(H,10,11)
InChIKey
DRAQIXNADYAISI-UHFFFAOYSA-N
SMILES
C12NC=CC1=CC(C#N)=CN=2
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36/37
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
ADE000896
Product name
1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile
Purity
Aldrich
Packaging
1g
Price
$817
Updated
2025/07/31
TRC
Product number
B529798
Product name
1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile
Packaging
500mg
Price
$110
Updated
2021/12/16
Matrix Scientific
Product number
021145
Product name
1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile
Purity
98%
Packaging
500mg
Price
$55
Updated
2021/12/16
Matrix Scientific
Product number
021145
Product name
1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile
Purity
98%
Packaging
1g
Price
$84
Updated
2021/12/16
Oakwood
Product number
079736
Product name
5-Cyano-7-azaindole
Purity
98%
Packaging
1g
Price
$85
Updated
2021/12/16
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1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE Chemical Properties,Usage,Production

Chemical Properties

Yellow fine crystalline powder

Uses

5-Cyano-7-azaindole is a commonly used intermediate in the synthesis of new anti-tumor drug protease inhibitors, mainly used in laboratory research and development processes and chemical production processes.

Synthesis

557-21-1

183208-35-7

517918-95-5

1. 5-Bromo-1H-pyrrolo[2,3-b]pyridine (5.0 g, 25.0 mmol, 1.0 eq.) and zinc cyanide (3.6 g, 20.0 mmol, 0.8 eq.) were dissolved in anhydrous DMF (65 mL) and deoxygenated for 30 min under argon protection. 2. tetrakis(triphenylphosphine)palladium (1.7 g, 1.5 mmol, 0.06 eq.) was added and the reaction mixture was heated at 80 °C for 36 hours. 3. After completion of the reaction, the reaction was quenched with water and extracted with ethyl acetate (EtOAc). 4. The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated to dryness under reduced pressure. 5. The residue was treated with a small amount of dichloromethane (CH2Cl2) and the precipitate was collected by filtration. 6. The precipitate was washed with dichloromethane and dried over air to give 1H-pyrrolo[2,3-b]pyridine-5-carbonitrile (Intermediate 2a) as a white solid (3.0 g; yield: 83%; UPLC purity: 100%).

References

[1] Patent: US2018/179199, 2018, A1. Location in patent: Paragraph 0451-0452
[2] Patent: WO2004/78756, 2004, A2. Location in patent: Page 120-121
[3] Patent: EP1782811, 2007, A1. Location in patent: Page/Page column 63
[4] Patent: WO2014/73904, 2014, A1. Location in patent: Paragraph 1425-1427

1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE Suppliers

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View Lastest Price from 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE manufacturers

Dideu Industries Group Limited
Product
1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE 517918-95-5
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-26
Career Henan Chemical Co
Product
1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE 517918-95-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500kg
Release date
2019-12-25

517918-95-5, 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILERelated Search:

1H-Pyrrolo[3,2-b]pyridine-5-carbonitrile(9CI) 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE 1H-Pyrrolo[2,3-b]pyridine-4-carbonitrile(9CI),1H-PYRROLO[2,3-B]PYRIDINE-4-CARBONITRILE 5-CYANO-6-METHYL-7-AZAINDOLE 3-IODO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE 1-BENZENESULFONYL-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE METHYL 5-CYANO-1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLATE 4-Chloro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile 1H-Pyrrolo[2,3-b]pyridine-4-carbonitrile, 3-formyl- 1H-Pyrrolo[2,3-b]pyridine-4-carbonitrile, 6-bromo- 1H-Pyrrolo[2,3-c]pyridine-7-carbonitrile,4-methoxy-(9CI) 1H-Pyrrolo[2,3-b]pyridine-4-carbonitrile, 3-bromo- 1H-PYRROLO[3,2-C]PYRIDINE-4-CARBONITRILE 1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 4-chloro-1-(phenylsulfonyl)- 3-IODO-1H-PYRROLO[2,3-B]PYRIDINE-4-CARBONITRILE 1H-Pyrrolo[2,3-b]pyridine-4-carbonitrile, 6-methyl- 5-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE-4-CARBONITRILE 1H-Pyrrolo[2,3-c]pyridine-7-carbonitrile,2,3-dihydro-5-methoxy-(9CI)

  • 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE
  • 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile(9CI)
  • 5-CYANO-7-AZAINDOLE
  • 5-canyo-1H-Pyrrolo[2,3-b]pyridine
  • 7-Azaindole-5-carbonitrile
  • 7-Azaindole-5-carbonitrile,1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile
  • 5-Cyano-1H-pyrrolo[2,3-b]pyridine
  • 7-Azaindole-5-carbonitrile,97%
  • 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE ISO 9001：2015 REACH
  • 517918-95-5
  • PYRIDINE
  • Boron, Nitrile, Thio,& TM-Cpds
  • Heterocycles
  • Heterocycle-Pyridine series