ChemicalBook > CAS DataBase List > ReModelin hydrobroMide
ReModelin hydrobroMide
- Product Name
- ReModelin hydrobroMide
- CAS No.
- 1622921-15-6
- Chemical Name
- ReModelin hydrobroMide
- Synonyms
- CS-1751;Remodelin HBR;ReModelin hydrobroMide;ReModelin hydrobroMide USP/EP/BP;Remodelin hydrobromide, 10 mM in DMSO;4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile;4-(2-(2-Cyclopentylidenehydrazinyl)thiazol-4-yl)benzonitrile hydrobromide;4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile, hydrobromide (1:1);Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-, hydrobromide (1:1);HGPS,inhibit,telomerase,N-acetyltransferase,HATs,HAT,migration,Remodelin hydrobromide,Inhibitor,HCC,Histone Acetyltransferase
- CBNumber
- CB22729374
- Molecular Formula
- C15H15BrN4S
- Formula Weight
- 363.2754
- MOL File
- 1622921-15-6.mol
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ReModelin hydrobroMide Property
- storage temp.
- Store at -20°C
- solubility
- ≥36.3 mg/mL in DMSO; insoluble in H2O; ≥2.6 mg/mL in EtOH with ultrasonic
- form
- Powder
- color
- Light yellow to yellow
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 5.31066
- Product name
- Remodelin
- Packaging
- 25 mg
- Price
- $227
- Updated
- 2025/07/31
Cayman Chemical
- Product number
- 16066
- Product name
- Remodelin (hydrobromide)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 16066
- Product name
- Remodelin (hydrobromide)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 16066
- Product name
- Remodelin (hydrobromide)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $283
- Updated
- 2024/03/01
TRC
- Product number
- R143650
- Product name
- Remodelin hydrobromide
- Packaging
- 50mg
- Price
- $350
- Updated
- 2021/12/16
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ReModelin hydrobroMide Chemical Properties,Usage,Production
Uses
Remodelin acts as a potent acetyl-transferase NAT10 inhibitor, which is shown to correct defects of laminopathic cells. Anti-aging.
Biological Activity
remodelin is a potent inhibitor of nat10 [1].n-acetyltransferase 10 (nat10) is the only identified lysine acetyltransferase that acts on microtubules and histones [1]. nat10 mainly exists in the nucleolus.remodelin is a potent nat10 inhibitor. in lamin a/c depletion (silmna) cells, remodelin remodeled nuclear architecture through inhibition of nat10 lysine acetyltransferase activity. in cells derived from lmna-mutated hgps patients and primary mrc5 fibroblasts aged in culture, remodelin significantly decreased the prevalence of misshapen nuclei. in u2os cells and normal fibroblasts, remodelin inhibited nuclear shape defects induced by farnesyltransferase inhibitors (fti). in hgps cells, remodelin reduced the amount of misshapen nuclei, suggesting that inhibition of nat10 mediated nuclear shape normalization. also, remodelin reduced dna damage signaling, reduced sun1 accumulation at the nuclear envelope, reduced the levels of autophosphorylated atm and dna double-strand break markers γh2ax, and improved chromatin and nucleolar organization. in silmna and hgps cells, remodelin inhibited microtubule anchorage to centrosomes [1].
References
[1]. larrieu d, britton s, demir m, et al. chemical inhibition of nat10 corrects defects of laminopathic cells. science, 2014, 344(6183): 527-532.
ReModelin hydrobroMide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ReModelin hydrobroMide manufacturers
Career Henan Chemical Co
- Product
- Remodelin (hydrobromide) 1622921-15-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-30