ChemicalBook > CAS DataBase List > ReModelin hydrobroMide

ReModelin hydrobroMide

Product Name
ReModelin hydrobroMide
CAS No.
1622921-15-6
Chemical Name
ReModelin hydrobroMide
Synonyms
CS-1751;Remodelin HBR;ReModelin hydrobroMide;ReModelin hydrobroMide USP/EP/BP;Remodelin hydrobromide, 10 mM in DMSO;4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile;4-(2-(2-Cyclopentylidenehydrazinyl)thiazol-4-yl)benzonitrile hydrobromide;4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile, hydrobromide (1:1);Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-, hydrobromide (1:1);HGPS,inhibit,telomerase,N-acetyltransferase,HATs,HAT,migration,Remodelin hydrobromide,Inhibitor,HCC,Histone Acetyltransferase
CBNumber
CB22729374
Molecular Formula
C15H15BrN4S
Formula Weight
363.2754
MOL File
1622921-15-6.mol
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ReModelin hydrobroMide Property

storage temp. 
Store at -20°C
solubility 
≥36.3 mg/mL in DMSO; insoluble in H2O; ≥2.6 mg/mL in EtOH with ultrasonic
form 
Powder
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16066
Product name
Remodelin (hydrobromide)
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
16066
Product name
Remodelin (hydrobromide)
Purity
≥98%
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
16066
Product name
Remodelin (hydrobromide)
Purity
≥98%
Packaging
10mg
Price
$283
Updated
2024/03/01
TRC
Product number
R143650
Product name
Remodelin hydrobromide
Packaging
50mg
Price
$350
Updated
2021/12/16
TRC
Product number
R143650
Product name
Remodelin hydrobromide
Packaging
1mg
Price
$45
Updated
2021/12/16
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ReModelin hydrobroMide Chemical Properties,Usage,Production

Uses

Remodelin acts as a potent acetyl-transferase NAT10 inhibitor, which is shown to correct defects of laminopathic cells. Anti-aging.

Biological Activity

remodelin is a potent inhibitor of nat10 [1].n-acetyltransferase 10 (nat10) is the only identified lysine acetyltransferase that acts on microtubules and histones [1]. nat10 mainly exists in the nucleolus.remodelin is a potent nat10 inhibitor. in lamin a/c depletion (silmna) cells, remodelin remodeled nuclear architecture through inhibition of nat10 lysine acetyltransferase activity. in cells derived from lmna-mutated hgps patients and primary mrc5 fibroblasts aged in culture, remodelin significantly decreased the prevalence of misshapen nuclei. in u2os cells and normal fibroblasts, remodelin inhibited nuclear shape defects induced by farnesyltransferase inhibitors (fti). in hgps cells, remodelin reduced the amount of misshapen nuclei, suggesting that inhibition of nat10 mediated nuclear shape normalization. also, remodelin reduced dna damage signaling, reduced sun1 accumulation at the nuclear envelope, reduced the levels of autophosphorylated atm and dna double-strand break markers γh2ax, and improved chromatin and nucleolar organization. in silmna and hgps cells, remodelin inhibited microtubule anchorage to centrosomes [1].

References

[1]. larrieu d, britton s, demir m, et al. chemical inhibition of nat10 corrects defects of laminopathic cells. science, 2014, 344(6183): 527-532.

ReModelin hydrobroMide Preparation Products And Raw materials

Raw materials

Preparation Products

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ReModelin hydrobroMide Suppliers

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View Lastest Price from ReModelin hydrobroMide manufacturers

Career Henan Chemical Co
Product
Remodelin (hydrobromide) 1622921-15-6
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-30

1622921-15-6, ReModelin hydrobroMideRelated Search:

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  • ReModelin hydrobroMide USP/EP/BP
  • 4-(2-(2-Cyclopentylidenehydrazinyl)thiazol-4-yl)benzonitrile hydrobromide
  • HGPS,inhibit,telomerase,N-acetyltransferase,HATs,HAT,migration,Remodelin hydrobromide,Inhibitor,HCC,Histone Acetyltransferase
  • Remodelin hydrobromide, 10 mM in DMSO
  • 1622921-15-6
  • C15H14N4SHBr
  • C15H15BrN4S
  • Inhibitors
  • ReModelin