TAPI-1

Product Name: TAPI-1
CAS No.: 171235-71-5
Chemical Name: TAPI-1
Synonyms: TAP 1;CS-1499;(S,S)-TAPI-1;(2S,2S)-TAPI-1;TAPI-1 TFA Salt;2-aminoethyl Amide;TAPI-1 trifluoroacetate;TNF-α Protease Inhibitor-1;TNF-Α PROTEASE INHIBITOR-1 (TAPI-1);N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine
CBNumber: CB22729657
Molecular Formula: C26H37N5O5
Formula Weight: 499.6
MOL File: 171235-71-5.mol

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TAPI-1 Property

Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: -20C
solubility: ≥24.98 mg/mL in DMSO; ≥15.77 mg/mL in EtOH with ultrasonic; ≥18.1 mg/mL in H2O
form: White solid
pka: 9.17±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 579051
Product name: TAPI-1 - CAS 171235-71-5 - Calbiochem<br />TAPI-1, CAS 171235-71-5, is a structural analog of TAPI-0 with similar in vitro efficacy for the inhibition of MMPs and TACE. Blocks the shedding of several cell surface proteins.
Packaging: 1mg
Price: $475
Updated: 2024/03/01

Cayman Chemical

Product number: 18505
Product name: TAPI-1
Purity: ≥98%
Packaging: 500μg
Price: $149
Updated: 2024/03/01

Cayman Chemical

Product number: 18505
Product name: TAPI-1
Purity: ≥98%
Packaging: 1mg
Price: $253
Updated: 2024/03/01

Cayman Chemical

Product number: 18505
Product name: TAPI-1
Purity: ≥98%
Packaging: 5mg
Price: $894
Updated: 2024/03/01

Usbiological

Product number: 493389
Product name: TAP1
Packaging: 100ul
Price: $529
Updated: 2021/12/16

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TAPI-1 Chemical Properties,Usage,Production

Uses

TAPI-1 Trifluoroacetic Acid Salt is a TNF-a converting enzyme (TACE) inhibitor, which blocks shedding of cytokine receptors. It is a modulation of juxtamembrane cleavage (shedding) of angiotensin-converting enzyme by stalking glycosylation in relation to an alternative shedding protease.

General Description

A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE (TNF-α convertase; ADAM17). However, TAPI-1 is more stable in serum than TAPI-0. TAPI-1 Blocks the shedding of several cell surface proteins such as TNF-α, IL-6 receptor, and p60 and p80 TNF receptors. Inhibits constitutive (IC₅₀ = 8.09 μM) and muscarinic receptor-stimulated (IC₅₀ = 3.61 μM) sAPPa release in HEK-293 cells expressing muscarinic receptors. Also blocks the TACE-dependent constitutive release of co-transfected APP(695) (IC₅₀ = 920 nM).

Biological Activity

tapi-1 is an inhibitor of tumour necrosis factor with ic50 value of 8.09 μm [1].tapi-1 is an inhibitor of tace/adam17 which catalyzes the cleavage of full-length app to the soluble n-terminal fragment (sappα). the release of sappα has been reported to be a receptor-coupled process increased by the stimulation of muscarinic receptors. in hek293 cells, treatment of tapi-1 resulted in an inhibition of increased sappα which was induced by the expressing of m3 subtype. the ic50 values of tapi-1 in the inhibition of m3-increased sappα and constitutive release of sappα were 3.61 μm and 8.09 μm, respectively. besides app, tapi-1 was also found to have inhibitory effects on the release of tnf-α, il6r, tnfri and tnfrii with ic50 values of 50-100, 5-10, 5-10 and 25-50 mm, respectively [1, 2].

Biochem/physiol Actions

Primary TargetMMPs and TACE

References

[1] slack b, ma l, seah c. constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-α converting enzyme. biochem. j, 2001, 357: 787-794.
[2] hooper n, karran e, turner a. membrane protein secretases. biochem. j, 1997, 321: 265-279.

TAPI-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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TAPI-1 Suppliers

China 46 India 1 United States 10 Global 57

Alabiochem Tech.Co., Ltd.

Tel: 0512-58900862 400-0707518
Fax: 0086-512-56765862
Email: sales@alabiochem.com
Country: China
ProdList: 995
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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4512
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2994
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Alabiotech Inc.

Tel: 001-619-354-5251
Fax: 001-855-855-6087
Email: sales@alabiotech-e.com
Country: United States
ProdList: 972
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
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171235-71-5, TAPI-1Related Search:

DAPT PD 151746 VX-661

N1-((S)-1-((S)-1-(2-aminoethylamino)-1-oxopropan-2-ylamino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide

N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-alaninamide

N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-alaninamide TAPI-1

TNF-Α PROTEASE INHIBITOR-1 (TAPI-1)

TAPI-1 trifluoroacetate

2-aminoethyl Amide

N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine

N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-NAPHTHYLALANYL-L-ALANINE; 2-AMINOETHYL AMIDE; TNF-Α PROTEASE INHIBITOR-1

TNF-α Protease Inhibitor-1

(2S,2S)-TAPI-1

CS-1499

TAP 1

L-Alaninamide, N-[2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)- (9CI)

TAPI-1 TFA Salt

(S,S)-TAPI-1

171235-71-5

C26H37N5O5

Inhibitors