DAPT

Product Name: DAPT
CAS No.: 208255-80-5
Chemical Name: DAPT
Synonyms: DAPT (GSI-IX);GSI-IX;CS-175;AN-37124;SC-201315;DAPT DAPT;DAPT, >=98%;GSI-IX; GSI IX;EZSolution DAPT;Synonyms GSI-IX
CBNumber: CB3503380
Molecular Formula: C23H26F2N2O4
Formula Weight: 432.46
MOL File: 208255-80-5.mol

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DAPT Property

alpha: +40.0～+47.0°(D/20℃)(c=0.5,DMSO)
Boiling point:: 612.2±55.0 °C(Predicted)
Density: 1.213
storage temp.: 2-8°C
solubility: DMSO: ~18 mg/mL
form: solid
pka: 12.82±0.46(Predicted)
color: white
Sensitive: Light Sensitive
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey: DWJXYEABWRJFSP-XOBRGWDASA-N
CAS DataBase Reference: 208255-80-5

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 565770
Product name: γ-Secretase Inhibitor IX
Packaging: 5mg
Price: $172
Updated: 2024/03/01

Sigma-Aldrich

Product number: 565770
Product name: γ-Secretase Inhibitor IX
Packaging: 10mg
Price: $230
Updated: 2024/03/01

TCI Chemical

Product number: D4257
Product name: DAPT
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $440
Updated: 2024/03/01

Alfa Aesar

Product number: J65864
Product name: DAPT
Packaging: 10mg
Price: $227
Updated: 2024/03/01

Cayman Chemical

Product number: 13197
Product name: DAPT
Purity: ≥95%
Packaging: 5mg
Price: $59
Updated: 2024/03/01

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DAPT Chemical Properties,Usage,Production

Description

DAPT (208255-80-5) is an inhibitor of γ-secretase (IC50 in human primary neurons = 115 nM for total Aβ or 200 nM for Aβ42 specifically).1?Oral administration of DAPT has been shown to reduce levels of Aβ in brain extract, cerebrospinal fluid and plasma from mice and rats.2,3?DAPT blocks Notch signaling which promotes neuronal differentiation of precursor cells.4?Enhances iPS cells without oncogenes KLF4 and CMYC5. Cell permeable.

Uses

DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells

Uses

A potent and specific inhibitor of γ-secretase.

Uses

DAPT is used in the study of β-amyloid formation. DAPT has been shown to inhibit Notch signaling in studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus, as well as in cancer cell growth, angiogenesis, and differentiation of human induced pluripotent stem cells.

Definition

ChEBI: DAPT is a dipeptide consisting of alanylphenylglycine derivatised as a 3,5-difluorophenylacetamide at the amino terminal and a tert-butyl ester at the carboxy terminal. A gamma-secretase inhibitor. It has a role as an EC 3.4.23.46 (memapsin 2) inhibitor. It is a dipeptide, a difluorobenzene, a carboxylic ester and a tert-butyl ester.

Biological Activity

Inhibitor of γ -secretase; causes a reduction in A β 40 and A β 42 levels in human primary neuronal cultures (IC 50 values are 115 and 200 nM for total A β and A β 42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo . Does not effect APP α and APP β levels. Blocks Notch signaling in hybrid human-mouse foetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation.

Biochem/physiol Actions

DAPT is a γ-secretase inhibitor and indirectly an inhibitor of Notch, a γ-secretase substrate. Other γ-secretase substrates include LDL receptor-related protein, E-cadherin and ErbB-4. As an inhibitor of γ-secretase, DAPT may be useful in the study of β-amyloid (Aβ) formation. DAPT has been shown to inhibit Notch signaling in studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus (SLE), as well as in cancer cell growth, angiogenesis, and differentiation of human induced pluripotent stem cells (hIPSC).

storage

+4°C

References

1) Dovey?et al. (2001),?Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain; J. Neurochem.,?76?173 2) Portelius?et al. (2009),?Effects of γ-secretase inhibition on the amyloid β isoform pattern in a mouse model of Alzheimer’s disease; Cell Signal.,?5?615 3) El Moueddon?et al. (2006),?Reduction of Aβ levels in the Sprague Dawley rat after oral administration of the functional γ-secretase inhibitor, DAPT: a novel non-transgenic model for Aβ production inhibitors; Curr. Pharma. Des.,?12?1671 4) De Smedt?et al. (2005), Different thresholds of notch signaling bias human precursor cells towards B-, NK-, monocytic/dendritic, or T-cell lineage in thymus microenvironment; Blood,?106?2236 5) Ichida?et al. (2014),?Notch inhibition allows oncogene-independent generation of iPS cells; Nature Chem. Biol.,?10?632

DAPT Preparation Products And Raw materials

Raw materials

Preparation Products

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DAPT Suppliers

Americas 1 Canada 1 China 155 Europe 1 France 1 Germany 5 India 3 Japan 2 Poland 1 Switzerland 1 The Netherlands 2 United Kingdom 7 United States 42 Global 222

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

ZHIWE CHEMTECH CO LTD

Tel: 021-20221225 13917446399
Fax: QQ:115820162
Email: sales@zhiwe.net
Country: China
ProdList: 608
Advantage: 61

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Ark Pharm, Inc.

Tel: 847-367-3680
Fax: 847-367-3681
Email: sales@arkpharminc.com
Country: United States
ProdList: 1670
Advantage: 56

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

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View Lastest Price from DAPT manufacturers

Career Henan Chemical Co

Product: DAPT 208255-80-5
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100g , 1kg, 5kg , 50kg
Release date: 2020-01-07

208255-80-5, DAPTRelated Search:

JAK3 INHIBITOR I P7C3 Neuropathiazol BETA-SECRETASE INHIBITOR IV GAMMA-SECRETASE INHIBITOR DIBENZAZEPINE γ-Secretase Inhibitor XXI Y27632 (hydrochloride) Semagacestat SB 431542 MG-132 LY411575 RO4929097 DAPM DAPT AC-PHG-OME H-PHG-OTBU (S)-ALPHA-AMINOBENZENEACETIC ACID ETHYL ESTER

(2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenylglycine 1,1-dimethylethyl ester

GSI-IX; GSI IX

CS-175

γ-Secretase Inhibitor IX - CAS 208255-80-5 - Calbiochem

LY-374973, N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester

N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethylester

SC-201315

(2S)-N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-2-phenylglycine tert-butyl ester

DAPT (enzyme inhibitor)

GSI-IX

DAPT (GSI-IX)

γ-Secretase Inhibitor IX

tert-butyl (2R)-[((2S)-2-{[(3,5-difluorophenyl)acetyl]aMino}propanoyl)aMino](phenyl)ethanoate

Glycine, N-[(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-,1,1-diMethylethyl ester, (2S)-

(S)-tert-butyl 2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate

2S)-N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-2-phenylglycine tert-butyl ester DAPT (enzyme inhibitor)

DAPT DAPT (enzyme inhibitor)

Synonyms GSI-IX

EZSolution DAPT

DAPT, >=98%

(3,5-Difluorophenylacetyl)-L-alanyl-L-2-phenylglycine tert-Butyl Ester

SC-201315 DAPT

tert-butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate

Glycine, N-[2-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-

tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate

one of γ-Secretase inhibitor

N-(3-((3aS,7aS)-6-amino-3,3a,4,7a-tetrahydro-1H-thiopyrano[3,4-c]furan-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide

DAPT, 98%, a γ-secretase inhibitor

N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester(DAPT)

γ-Secretase Inhibitor DAPT

GSI-IX;GSI IX;LY-374973

DAPT DAPT

N-[2-(3,5-Difluorophenyl)acetyl]-L-alanyl-L-(2-phenyl)glycine tert-butyl ester

γ-Secretase Inhibitor DAPT

γ-Secretase Inhibitor DBZ

γ-Secretase Inhibitor IX

DAPT (GSI-IX, LY-374973)

N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,2-dimethylethyl ester(DAPT)

γ-Secretase Inhibitor IX DAPT

AN-37124

LY-374973|||GSI-IX

208255-80-5

C23H26F2N2O4

C23H26O4N2F2

GSI-IX

Inhibitor

Angiogenesis and Metastasis

Protease inhibitor

Inhibitors