P7C3
- Product Name
- P7C3
- CAS No.
- 301353-96-8
- Chemical Name
- P7C3
- Synonyms
- P7C3;CS-1463;P7C3, >97%;P7C3, >=98%;P7C3; 301353-96-8;P7C3, 10 mM in DMSO;1-anilino-3-(3,6-dibromocarbazol-9-yl)propan-2-ol;P7C3, pro-neurogenic and neuroprotective compound;6-Dibromo-α-[(phenylamino)methyl]-9H-carbazole-9-ethanol;3,6-Dibromo-α-[(phenylamino)methyl]-9H-carbazole-9-ethanol
- CBNumber
- CB62535687
- Molecular Formula
- C21H18Br2N2O
- Formula Weight
- 474.19
- MOL File
- 301353-96-8.mol
P7C3 Property
- Boiling point:
- 656.4±55.0 °C(Predicted)
- Density
- 1.61±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble34mg/mL
- pka
- 13.91±0.20(Predicted)
- form
- powder
- color
- white to off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
- InChI
- 1S/C21H18Br2N2O/c22-14-6-8-20-18(10-14)19-11-15(23)7-9-21(19)25(20)13-17(26)12-24-16-4-2-1-3-5-16/h1-11,17,24,26H,12-13H2
- InChIKey
- FZHHRERIIVOATI-UHFFFAOYSA-N
- SMILES
- OC(CNc1ccccc1)Cn2c3ccc(Br)cc3c4cc(Br)ccc24
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H318Causes serious eye damage
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D8446
- Product name
- P7C3
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $157
- Updated
- 2026/03/19
- Product number
- D8446
- Product name
- P7C3
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $619
- Updated
- 2026/03/19
- Product number
- 16682
- Product name
- P7C3
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $105
- Updated
- 2024/03/01
- Product number
- 16682
- Product name
- P7C3
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $176
- Updated
- 2024/03/01
- Product number
- 16682
- Product name
- P7C3
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $410
- Updated
- 2024/03/01
P7C3 Chemical Properties,Usage,Production
Description
P7C3 is an orally bioavailable and brain penetrant aminopropyl carbazole that exhibits proneurogenic and neuroprotective activity by preventing apoptosis of newly postmitotic neurons in the subgranular zone of the hippocampal dentate gyrus. At doses of 5 mg/kg and above, it has been shown to promote the survival of neurons in various rodent models of neurodegeneration or nerve injury. While the precise mechanism of action through which these effects are exerted remains uncertain, P7C3 recently has been shown to bind nicotinamide phosphoribosyltransferase, the rate-limiting enzyme involved in the conversion of nicotinamide into NAD.
Uses
P7C3 is an aminopropyl carbazole agent with proneurogenic and neuroprotective properties in newborn neural precursor cells of the dentate gyrus. Its analogs may be used in neurodegenerative disease research to study the process of neurogenesis in brain regions such as the subgranular zone of the hippocampal dentate gyrus. P7C3 and its analogs may be used to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as potential drug for the treatment of condition such as Alzheimer′s disease, Parkinson′s disease, amyotrophic lateral sclerosis and traumatic brain injury.
Biochem/physiol Actions
P7C3 is neurogenic and protects new neurons against apoptosis. These activities may be related to its capacity to protect mitochondrial integrity.Degeneration of the hippocampus is an early manifestation of Alzheimer′s disease. P7C3 promotes neurogenesis in the subgranular zone of the hippocampal dentate gyrus, the site of normal neurogenesis in adult mammals, making it an important lead compound in development of new Alzheimer′s treatments.
in vivo
P7C3 (20 mg/kg/d; i.p.; twice daily; for 21 days ) inhibits microglial activation and microglia-mediated dopaminergic (DA) neuronal loss in vivo[3].
| Animal Model: | 6-8 weeks male C57BL/6 mice (25-30 g)[3] |
| Dosage: | 20 mg/kg/d |
| Administration: | Intraperitoneal injection, twice daily, for 21 days |
| Result: | Strikingly decreased the expressions of (a microglia marker) and GFAP (an astrocyte marker) LPS-induced in the substantia nigra pars compacta (SNpc). |
storage
Store at RT
References
[1] ANDREW A PIEPER. Discovery of a proneurogenic, neuroprotective chemical.[J]. Cell, 2010: 39-51. DOI:10.1016/j.cell.2010.06.018
[2] RACHEL TESLA. Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis.[J]. ACS Catalysis , 2012: 17016-17021. DOI:10.1073/pnas.1213960109
[3] HÉCTOR DE JESÚS-CORTÉS. Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease.[J]. ACS Catalysis , 2012: 17010-17015. DOI:10.1073/pnas.1213956109
[4] SARAH E. LATCHNEY . Erratum to “Chronic P7C3 treatment restores hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome” [Neurosci. Lett. 591 (2015) 86–92][J]. Neuroscience Letters, 2015, 597: Page 25. DOI:10.1016/j.neulet.2015.04.024
[5] GELIN WANG. P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage.[J]. Cell, 2014: 1324-1334. DOI:10.1016/j.cell.2014.07.040
P7C3 Preparation Products And Raw materials
Raw materials
Preparation Products
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