LDN-57444
- Product Name
- LDN-57444
- CAS No.
- 668467-91-2
- Chemical Name
- LDN-57444
- Synonyms
- CS-988;LDN-57444;UCH-L1 Inhibitor;LDN 57444, >=98%;LDN-57444/LDN57444;LDN-57444 USP/EP/BP;UCH-L1 INHIBITOR;LDN57444;UCH-L1 Inhibitor - CAS 668467-91-2 - Calbiochem;3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one;(Z)-3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one
- CBNumber
- CB5804575
- Molecular Formula
- C17H11Cl3N2O3
- Formula Weight
- 397.64
- MOL File
- 668467-91-2.mol
LDN-57444 Property
- Boiling point:
- 534.4±60.0 °C(Predicted)
- Density
- 1.50±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble16mg/mL
- form
- solid
- pka
- -2.57±0.20(Predicted)
- color
- Yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- L4170
- Product name
- LDN-57444
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- 662086
- Product name
- UCH-L1 Inhibitor
- Packaging
- 10mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 15396
- Product name
- LDN-57444
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 15396
- Product name
- LDN-57444
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $78
- Updated
- 2024/03/01
- Product number
- L4170
- Product name
- LDN-57444
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $470
- Updated
- 2024/03/01
LDN-57444 Chemical Properties,Usage,Production
Description
The ubiquitin C-terminal hydrolase L1 (UCH-L1) is a member of a family of de-ubiquitinating enzymes that can generate free ubiquitin from ubiquitin precursors via its ubiquitin ligase activity. By associating with free ubiquitin, it also prevents its degradation. Neuronal UCH-L1 has been linked to Parkinson’s disease, the development of tumors, and neuropathic pain. LDN-57444 is an inhibitor of UCH-L1 activity (IC50 = 0.88, Ki = 0.4 μM) that demonstrates selectivity for UCH-L1 compared to UCH-L3 (IC50 = 25 μM). Loss of UCH-L1 activity causes cell death through the apoptosis pathway due to an impaired ubiquitin-proteasome pathway. LDN-57444-induced reduction of free ubiquitin has been shown to create dramatic alterations in synaptic structure and function, increasing spine size while decreasing spine density in hippocampal neurons.
Uses
LDN 57444 is an inhibitor of UCH-L1, an enzyme expressed by certain lung tumor-derived cell lines, suggesting that this enzyme plays a role in tumor progression.
Biochem/physiol Actions
LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1
References
1) Liu et al. (2003), Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line; Chem. Biol., 10 837 2) Tan et al. (2008), Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor; Mol. Cell. Biochem., 318 109 3) Cartier et al. (2009), Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1; J. Neurosci., 29 7857
LDN-57444 Preparation Products And Raw materials
Raw materials
Preparation Products
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