2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione

Product Name: 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione
CAS No.: 332382-54-4
Chemical Name: 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione
Synonyms: ML-SA1;STK095286;EU-0040486;BAS 01520422;MLS000526272;SMR000116746;Oprea1_383174;Oprea1_593964;CBMicro_009667;ChemDiv1_023217
CBNumber: CB92555129
Molecular Formula: C22H22N2O3
Formula Weight: 362.42
MOL File: 332382-54-4.mol

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2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione Property

Boiling point:: 546.7±43.0 °C(Predicted)
Density: 1.226±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL, clear (warmed)
form: powder
pka: 1.16±0.60(Predicted)
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

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Safety

Hazard Codes: T
Risk Statements: 25-50/53
Safety Statements: 60-61
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0627
Product name: ML-SA1
Purity: ≥95% (HPLC)
Packaging: 25mg
Price: $156
Updated: 2024/03/01

Cayman Chemical

Product number: 29958
Product name: ML-SA1
Packaging: 10mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 29958
Product name: ML-SA1
Packaging: 250mg
Price: $586
Updated: 2024/03/01

Cayman Chemical

Product number: 29958
Product name: ML-SA1
Packaging: 50mg
Price: $183
Updated: 2024/03/01

Cayman Chemical

Product number: 29958
Product name: ML-SA1
Packaging: 100mg
Price: $321
Updated: 2024/03/01

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2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione Chemical Properties,Usage,Production

Description

ML-SA1 (332382-54-4) is a?TRPML 1,2 and 3 channel activator.1?Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels.2?ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is comparable (10 μM) to the effect of the endogenous TRPML agonist, PI(3,5)P2?(1 μM).2?Thus it is a useful chemical tool for studying the functions of TRPMLs. It induces TRPML-mediated Ca2+?release from lysosomes which corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.2,3?Reduces intralysosomal Ca2+?level rescuing abnormal lysosomal storage in FIG4-deficient cells.4

Uses

ML-SA1 has been used as a transient receptor potential cation channel mucolipin 1 (TRPML1/ML1) agonist.

Biochem/physiol Actions

ML-SA1 is a potent and selective cell permeable agonist of lysosomal mucolipin transient receptor potential channels (TRPML) 1, 2, 3 that significantly increases [Ca2+]cyt in HEK293 cells stably- or transiently-expressing mutant TRPML1 channels ML1-4A.

storage

Store at +4°C

References

1) Grimm?et al. (2010),?Small molecule activators of TRPML3; Mol. Chem. Biol.,?17?135 2) Shen?et al. (2012),?Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release; Nature Commun.,?3?731 3) Weiss?et al. (2012),?Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases; Commun. Integer. Biol.,?5?111 4) Zou?et al. (2015),?Reactivation of lysosomal Ca2+ Efflux Rescues Abnormal Lysosomal Storage in FIG4-Deficient Cells;J. Neurosci., 35?6801

2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione Suppliers

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332382-54-4, 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dioneRelated Search:

1H-Purine-2,6-dione, 1-[11-(dodecylamino)-10-hydroxyundecyl]-3,7-dihydro-3,7-dimethyl- 2-BROMOHEXADECANOIC ACID LDN-57444 Endosidin 2

2-[2-oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1-yl)ethyl]isoindole-1,3-dione

TRPML Agonist, ML-SA1 - CAS 332382-54-4 - Calbiochem

2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione

2-[2-oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1-yl)ethyl]isoindoline-1,3-dione

BAS 01520422

BIM-0009825.P001

CBMicro_009667

ChemDiv1_023217

EU-0040486

MLS000526272

Oprea1_383174

Oprea1_593964

SMR000116746

STK095286

TRPML Agonist, ML-SA1

2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione

1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)acetyl]-1,2,3,4-tetrahydro-2,2,4-trimethyl-quinoline

2-(2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione

ML-SA1

Mucolipin Synthetic Agonist 1

2-[2-keto-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1-yl)ethyl]isoindoline-1,3-quinone

2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydro-2H-quinolin-1-yl)-ethyl]-isoindole-1,3-dione

1H-Isoindole-1,3(2H)-dione, 2-[2-(3,4-dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-

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332382-54-4