SKI II
- Product Name
- SKI II
- CAS No.
- 312636-16-1
- Chemical Name
- SKI II
- Synonyms
- SphK-I2;CS-1145;SKI II;SKI-II;SKI II - SKI 2;SKI II (SphK-I2);SKI II USP/EP/BP;SKIII(SphK-I2), >98%;Sphingosine Kinase Inhibitor;Sphingosine Kinase Inhibitor 2;SKI II (Sphingosine Kinase Inhibitor)
- CBNumber
- CB1498400
- Molecular Formula
- C15H11ClN2OS
- Formula Weight
- 302.78
- MOL File
- 312636-16-1.mol
SKI II Property
- Boiling point:
- 507.1±60.0 °C(Predicted)
- Density
- 1.415±0.06 g/cm3(Predicted)
- RTECS
- SK5900000
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥20 mg/mL
- form
- solid
- pka
- 10.17±0.26(Predicted)
- color
- off-white
- Sensitive
- Air & Light Sensitive
- CAS DataBase Reference
- 312636-16-1
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S5696
- Product name
- SKI II
- Purity
- ≥98% (HPLC), solid
- Packaging
- 10mg
- Price
- $209
- Updated
- 2024/03/01
- Product number
- S5696
- Product name
- SKI II
- Purity
- ≥98% (HPLC), solid
- Packaging
- 50mg
- Price
- $639
- Updated
- 2024/03/01
- Product number
- J67479
- Product name
- SKI-II, 98%
- Packaging
- 10mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 10009222
- Product name
- Sphingosine Kinase Inhibitor 2
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- 10009222
- Product name
- Sphingosine Kinase Inhibitor 2
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $76
- Updated
- 2024/03/01
SKI II Chemical Properties,Usage,Production
Uses
SKI II is a nonlipid inhibitor of sphingosine kinase. SKI II s orally bioavailable and has shown significant inhibition of tumor growth in mice.
Definition
ChEBI: 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]phenol is a substituted aniline.
Biological Activity
Selective non-lipid inhibitor of sphingosine kinase (IC 50 = 0.5 μ M); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKC α at concentrations up to 60 μ M. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC 50 = 0.9-4.6 μ M).
Biochem/physiol Actions
Sphingosine kinase (SK) plays a pivotal role in regulating tumor growth and SK can act as an oncogene. Expression of SK RNA is significantly elevated in a variety of solid tumors, compared with normal tissue from the same patient. A number of novel inhibitors of human SK were identified, and several representative compounds were characterized in detail. These compounds demonstrated activity at sub- to micromolar concentrations, making them more potent than any other reported SK inhibitor, and were selective toward SK compared with a panel of human lipid and protein kinases. Kinetic studies revealed that the compounds were not competitive inhibitors of the ATP-binding site of SK. 4-[4-(4-chloro-phenyl)-thiazol-2-ylamino]-phenol (SKI-II) inhibitor is orally bioavailable, detected in the blood for at least 8 h, and showed a significant inhibition of tumor growth in mice with IC50 = 0.5 μM; SKI II does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCa at concentrations up to 60 μM.SKI II induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC50 = 0.9-4.6 μM).
storage
Store at -20°C
References
[1] french kj, schrecengost rs, lee bd, zhuang y, smith sn, eberly jl, yun jk, smith cd. discovery and evaluation of inhibitors of human sphingosine kinase. cancer res. 2003 sep 15;63(18):5962-9.
SKI II Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from SKI II manufacturers
- Product
- SKI II 312636-16-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- Min98% HPLC/GC
- Supply Ability
- g/kg/ton Coreychem-Nicole406
- Release date
- 2020-11-06