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DBeQ

Product Name
DBeQ
CAS No.
177355-84-9
Chemical Name
DBeQ
Synonyms
JRF;DBeQ;JRF 12;CS-982;DBeQ (JRF 12);DBeQ USP/EP/BP;JRF 12; JRF12; JRF-12;N,N'-Dibenzylquinazoline-2,4-diamine;N,N'-Dibenzylquinazoline-2,4-diamine;N,N'-Dibenzyl-2,4-quinazolinediamine
CBNumber
CB02569682
Molecular Formula
C22H20N4
Formula Weight
340.42
MOL File
177355-84-9.mol
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DBeQ Property

Melting point:
149 °C
Boiling point:
573.1±52.0 °C(Predicted)
Density 
1.259±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: ≥20mg/mL
form 
powder
pka
7.78±0.30(Predicted)
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey
QAIMUUJJAJBPCL-UHFFFAOYSA-N
CAS DataBase Reference
177355-84-9
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36
Safety Statements 
26
WGK Germany 
3
HS Code 
2933.59.8000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0031
Product name
DBeQ
Purity
≥98% (HPLC)
Packaging
5mg
Price
$111
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0031
Product name
DBeQ
Purity
≥98% (HPLC)
Packaging
25mg
Price
$451
Updated
2024/03/01
TCI Chemical
Product number
D5476
Product name
DBeQ
Purity
>98.0%(HPLC)
Packaging
25mg
Price
$103
Updated
2024/03/01
TCI Chemical
Product number
D5476
Product name
DBeQ
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$308
Updated
2024/03/01
Cayman Chemical
Product number
15318
Product name
DBeQ
Purity
≥98%
Packaging
5mg
Price
$86
Updated
2024/03/01
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DBeQ Chemical Properties,Usage,Production

Description

DBeQ (177355-84-9) is a potent, selective and reversible inhibitor of the AAA-ATPase p97 (ATPase associated with diverse cellular activities). Ki=3.2 μM. DBeQ blocks ubiquitin-dependent protein clearance pathways. Cell permeable.

Uses

The ATPase p97 is an ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. DBeQ is a selective, reversible, and ATP-competitive inhibitor of the ATPase p97 (Ki = 3.2 μM; IC50 = 1.5 μM). It does not exhibit activity when tested against a panel 170 protein kinases at concentrations as high as 15 μM. At 10 μM it blocks endoplasmic reticulum-associated degradation, impairing the autophagy pathway and promoting the activation of caspase-3 and -7 in cancer cells.[Cayman Chemical]

Uses

HeLa cells were treated with DBeQ and the effects on in vivo ubiquitination and protein dislocation were studied by live cell imaging.

Biochem/physiol Actions

DBeQ is a potent and specific inhibitor of ATPase p97, an integral component of the ubiquitin-fusion degradation (UFD) pathway. DBeQ inhibits the degradation of ubiquitinated proteins, the endoplasmic reticulum-associated degradation pathway, and autophagosome maturation. The compound also potently inhibits cellular proliferation and induces caspase 3/7 activity and apoptosis.

storage

Store at +4°C

References

1) Chou et al. (2011), Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways; Proc. Natl. Acad. Sci. USA, 108 4834

DBeQ Preparation Products And Raw materials

Raw materials

Preparation Products

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DBeQ Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4727
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4674
Advantage
55
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58

177355-84-9, DBeQRelated Search:


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  • CS-982
  • DBeQ (JRF 12)
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  • N,N'-Dibenzyl-2,4-quinazolinediamine
  • 177355-84-9
  • API
  • Inhibitors