DBeQ

Product Name: DBeQ
CAS No.: 177355-84-9
Chemical Name: DBeQ
Synonyms: JRF;DBeQ;JRF 12;CS-982;DBeQ (JRF 12);DBeQ USP/EP/BP;JRF 12; JRF12; JRF-12;N,N'-Dibenzylquinazoline-2,4-diamine;N,N'-Dibenzylquinazoline-2,4-diamine;N2,N4-Dibenzylquinazoline-2,4-diamine
CBNumber: CB02569682
Molecular Formula: C22H20N4
Formula Weight: 340.42
MOL File: 177355-84-9.mol

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DBeQ Property

Melting point:: 149 °C
Boiling point:: 573.1±52.0 °C(Predicted)
Density: 1.259±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: ≥20mg/mL
form: powder
pka: 7.78±0.30(Predicted)
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey: QAIMUUJJAJBPCL-UHFFFAOYSA-N
CAS DataBase Reference: 177355-84-9

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Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26
WGK Germany: 3
HS Code: 2933.59.8000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0031
Product name: DBeQ
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $111
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0031
Product name: DBeQ
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $451
Updated: 2024/03/01

TCI Chemical

Product number: D5476
Product name: DBeQ
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $103
Updated: 2024/03/01

TCI Chemical

Product number: D5476
Product name: DBeQ
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $308
Updated: 2024/03/01

Cayman Chemical

Product number: 15318
Product name: DBeQ
Purity: ≥98%
Packaging: 5mg
Price: $86
Updated: 2024/03/01

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DBeQ Chemical Properties,Usage,Production

Description

DBeQ (177355-84-9) is a potent, selective and reversible inhibitor of the AAA-ATPase p97 (ATPase associated with diverse cellular activities). Ki=3.2 μM. DBeQ blocks ubiquitin-dependent protein clearance pathways. Cell permeable.

Uses

The ATPase p97 is an ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. DBeQ is a selective, reversible, and ATP-competitive inhibitor of the ATPase p97 (Ki = 3.2 μM; IC50 = 1.5 μM). It does not exhibit activity when tested against a panel 170 protein kinases at concentrations as high as 15 μM. At 10 μM it blocks endoplasmic reticulum-associated degradation, impairing the autophagy pathway and promoting the activation of caspase-3 and -7 in cancer cells.[Cayman Chemical]

Uses

HeLa cells were treated with DBeQ and the effects on in vivo ubiquitination and protein dislocation were studied by live cell imaging.

Biochem/physiol Actions

DBeQ is a potent and specific inhibitor of ATPase p97, an integral component of the ubiquitin-fusion degradation (UFD) pathway. DBeQ inhibits the degradation of ubiquitinated proteins, the endoplasmic reticulum-associated degradation pathway, and autophagosome maturation. The compound also potently inhibits cellular proliferation and induces caspase 3/7 activity and apoptosis.

storage

Store at +4°C

References

1) Chou et al. (2011), Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways; Proc. Natl. Acad. Sci. USA, 108 4834

DBeQ Preparation Products And Raw materials

Raw materials

Preparation Products

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DBeQ Suppliers

Americas 1 China 98 Europe 1 India 2 Japan 1 The Netherlands 1 United Kingdom 1 United States 19 Global 124

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

TCI Europe

Tel: 320-37350700
Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
ProdList: 23671
Advantage: 75

TCI AMERICA

Tel: 800-4238616
Fax: +1-888-520-1075 / +1-503-283-1987
Email: sales@tciamerica.com
Country: Americas
ProdList: 23653
Advantage: 75

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

177355-84-9, DBeQRelated Search:

Pevonedistat BAFILOMYCIN A1 AZD6738 SGC707 MS023 2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide Enasidenib Epacadostat (INCB024360) indoleaMine-2,3-dioxygenase inhibitor INCB024360 LLY-507 4-BroMo-N-(4-broMophenyl)-3-[[(phenylMethyl)aMino]sulfonyl]benzaMide NMS 873 Ezetimibe Cabozantinib Fingolimod hydrochloride Veliparib Givinostat (ITF2357)

DBeQ

2,4-QuinazolinediaMine, N2,N4-bis(phenylMethyl)-

2,4-QuinazolinediaMine, N,N'-bis(phenylMethyl)-

JRF 12

N,N'-Dibenzylquinazoline-2,4-diamine

N2,N4-Dibenzylquinazoline-2,4-diamine

JRF

N,N'-Dibenzylquinazoline-2,4-diamine DBeQ

N2,N4-Dibenzylquinazoline-2,4-diamine DBeQ

N,N'-Dibenzyl-2,4-quinazolinediamine, 99%

N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine

JRF 12; JRF12; JRF-12

CS-982

DBeQ (JRF 12)

DBeQ USP/EP/BP

N,N'-Dibenzylquinazoline-2,4-diamine

177355-84-9

API

Inhibitors