SGC707

Product Name: SGC707
CAS No.: 1687736-54-4
Chemical Name: SGC707
Synonyms: SGC707;CS-2192;SGC 707;SGC707;N-6-Isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]urea;Urea, N-6-isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-
CBNumber: CB73067021
Molecular Formula: C16H18N4O2
Formula Weight: 298.34
MOL File: 1687736-54-4.mol

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SGC707 Property

storage temp.: -20°C
solubility: Soluble in DMSO (up to 35 mg/ml)
form: solid
color: Beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17017
Product name: SGC707
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17017
Product name: SGC707
Purity: ≥98%
Packaging: 10mg
Price: $169
Updated: 2024/03/01

Cayman Chemical

Product number: 17017
Product name: SGC707
Purity: ≥98%
Packaging: 25mg
Price: $381
Updated: 2024/03/01

Cayman Chemical

Product number: 17017
Product name: SGC707
Purity: ≥98%
Packaging: 50mg
Price: $669
Updated: 2024/03/01

Tocris

Product number: 5367
Product name: SGC707
Purity: ≥98%(HPLC)
Packaging: 50
Price: $731
Updated: 2021/12/16

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SGC707 Chemical Properties,Usage,Production

Description

SGC707 (1687736-54-4) is a potent (IC50?= 31 nM) and selective allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).1? Selective against 31 other methyltransferases. An extremely useful probe for investigating the role of PRMT3 in normal and pathophysiology. Cell permeable and active in vivo.

Uses

SGC 707 is a potent, selective and cell-active allosteric inhibitor of PRMT3.

in vitro

the ic50 and kd value of sgc707 against prmt3was 31 ± 2 nm and 53 ± 2 nm respectively. sgc707 showed an outstanding selectivity for prmt3 against 31 other methyltransferases and a broad range of 250 non-epigenetic targets, g protein-coupled receptors (gpcrs), ion channels, and transporters. the residence time of sgc707 was 9.7 min. in both hek293 and a549 cells, sgc707 stabilized prmt3 with ec50 values of 1.3 μm and 1.6 μm, respectively. sgc707 treatment at high concentrations 50 and 100 mm for 72 h lead to some toxicity [1].

in vivo

in cd-1 male mice, intraperitoneal injection of sgc707 at 30 mg/kg for over 6 h showed good plasma exposure with the peak plasma level of 38 μm. after injection 6 h, the plasma level of sgc707 decreased to 208 nm. the half-life of sgc707 was about 1 h. the 30 mg/kg dose was well tolerated in the tested mouse model [1].

storage

Store at +4°C

References

1) Kaniskan?et al. (2015), A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3); Angew. Chem. Int. Ed. Engl., 54?5166

SGC707 Preparation Products And Raw materials

Raw materials

Preparation Products

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SGC707 Suppliers

China 84 India 1 United States 13 Global 98

Shanghai Boyle Chemical Co., Ltd.

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1687736-54-4, SGC707Related Search:

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SGC707

N-6-Isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]urea

SGC 707;SGC707

CS-2192

Urea, N-6-isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-

1687736-54-4

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