ChemicalBook > CAS DataBase List > SGC707

SGC707

Product Name
SGC707
CAS No.
1687736-54-4
Chemical Name
SGC707
Synonyms
SGC707;CS-2192;SGC 707;SGC707;N-6-Isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]urea;Urea, N-6-isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-
CBNumber
CB73067021
Molecular Formula
C16H18N4O2
Formula Weight
298.34
MOL File
1687736-54-4.mol
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SGC707 Property

storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 35 mg/ml)
form 
solid
color 
Beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17017
Product name
SGC707
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17017
Product name
SGC707
Purity
≥98%
Packaging
10mg
Price
$169
Updated
2024/03/01
Cayman Chemical
Product number
17017
Product name
SGC707
Purity
≥98%
Packaging
25mg
Price
$381
Updated
2024/03/01
Cayman Chemical
Product number
17017
Product name
SGC707
Purity
≥98%
Packaging
50mg
Price
$669
Updated
2024/03/01
Tocris
Product number
5367
Product name
SGC707
Purity
≥98%(HPLC)
Packaging
50
Price
$731
Updated
2021/12/16
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SGC707 Chemical Properties,Usage,Production

Description

SGC707 (1687736-54-4) is a potent (IC50?= 31 nM) and selective allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).1? Selective against 31 other methyltransferases. An extremely useful probe for investigating the role of PRMT3 in normal and pathophysiology. Cell permeable and active in vivo.

Uses

SGC 707 is a potent, selective and cell-active allosteric inhibitor of PRMT3.

in vitro

the ic50 and kd value of sgc707 against prmt3was 31 ± 2 nm and 53 ± 2 nm respectively. sgc707 showed an outstanding selectivity for prmt3 against 31 other methyltransferases and a broad range of 250 non-epigenetic targets, g protein-coupled receptors (gpcrs), ion channels, and transporters. the residence time of sgc707 was 9.7 min. in both hek293 and a549 cells, sgc707 stabilized prmt3 with ec50 values of 1.3 μm and 1.6 μm, respectively. sgc707 treatment at high concentrations 50 and 100 mm for 72 h lead to some toxicity [1].

in vivo

in cd-1 male mice, intraperitoneal injection of sgc707 at 30 mg/kg for over 6 h showed good plasma exposure with the peak plasma level of 38 μm. after injection 6 h, the plasma level of sgc707 decreased to 208 nm. the half-life of sgc707 was about 1 h. the 30 mg/kg dose was well tolerated in the tested mouse model [1].

storage

Store at +4°C

References

1) Kaniskan?et al. (2015), A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3); Angew. Chem. Int. Ed. Engl., 54?5166

SGC707 Preparation Products And Raw materials

Raw materials

Preparation Products

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SGC707 Suppliers

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1687736-54-4, SGC707Related Search:

6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Sulfanilamide SGC-GAK-1 SGC2085 SGC0946 SGC2085 AZD6738 MS023 2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide Enasidenib Epacadostat (INCB024360) indoleaMine-2,3-dioxygenase inhibitor INCB024360 LLY-507 4-BroMo-N-(4-broMophenyl)-3-[[(phenylMethyl)aMino]sulfonyl]benzaMide DBeQ

  • SGC707
  • N-6-Isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]urea
  • SGC 707;SGC707
  • CS-2192
  • Urea, N-6-isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-
  • 1687736-54-4
  • API