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BAFILOMYCIN A1

Product Name
BAFILOMYCIN A1
CAS No.
88899-55-2
Chemical Name
BAFILOMYCIN A1
Synonyms
CS-1163;afilomycin A1;BAFILOMYCIN A1;BAFILOMYCIN A1 95%;Bafilomycin A1,95%;BAFILOMYCIN A1, 98+%;Bafilomycin A1(Baf-A1);BAFILOMYCIN A1 USP/EP/BP;BAFILOMYCIN A1, STREPTOMYCES GRISEUS;BafilomycinA1fromStreptomycesgriseus
CBNumber
CB3743951
Molecular Formula
C35H58O9
Formula Weight
622.83
MOL File
88899-55-2.mol
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BAFILOMYCIN A1 Property

Melting point:
>106°C (dec.)
Boiling point:
582.86°C (rough estimate)
Density 
1.0594 (rough estimate)
refractive index 
1.5000 (estimate)
RTECS 
RN9781000
Flash point:
87℃
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 5 mg/ml, with warming).
form 
Powder or Solid
pka
12.66±0.70(Predicted)
color 
White to off-white
Water Solubility 
Soluble in methanol, ethanol, acetone and chloroform. Insoluble in water.
BRN 
4730700
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
3172
WGK Germany 
3
F 
10
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29419090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B1793
Product name
Bafilomycin A1 from Streptomyces griseus
Purity
≥90% (HPLC)
Packaging
2μg
Price
$86.8
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1661
Product name
Bafilomycin A1 Ready Made Solution
Purity
0.16?mMinDMSO,fromStreptomycesgriseus
Packaging
0.1ml
Price
$220
Updated
2024/03/01
Sigma-Aldrich
Product number
B1793
Product name
Bafilomycin A1 from Streptomyces griseus
Purity
≥90% (HPLC)
Packaging
10μg
Price
$210
Updated
2024/03/01
Sigma-Aldrich
Product number
5.08409
Product name
InSolution Bafilomycin A1, ≥97% by HPLC - CAS 88899-55-2 - Calbiochem
Purity
A 100 μM (15 μg/241 μL) sterile-filtered solution of Bafilomycin A1,
Packaging
15μG
Price
$280
Updated
2024/03/01
Sigma-Aldrich
Product number
196000
Product name
Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem
Purity
Bafilomycin A1, CAS 88899-55-2, acts as a highly potent and specific inhibitor of vacuolar-type H+-ATPase (Ki = 500 pM). Blocks the fusion of autophagosome with lysosome.
Packaging
10μG
Price
$201
Updated
2024/03/01
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BAFILOMYCIN A1 Chemical Properties,Usage,Production

Description

Bafilomycin A1 is a fungal metabolite that has been found in Streptomyces and has diverse biological activities. It is an inhibitor of vacuolar H+-ATPases (V-ATPases; Ki = 0.5 nM in N. crassa vacuolar membranes) and is greater than 1,000-fold selective for V-ATPases over Na+/K+-, Ca2+-, and H+-ATPases. Bafilomycin A1 (100 nM) inhibits autophagosome maturation and protein degradation in H-4-II-E cells. It inhibits chloroquine-induced apoptosis in primary cerebellar granule neurons (CGNs) but not chloroquine-induced inhibition of macroautophagy. Bafilomycin A1 (100 nM) reduces viral yield in the culture supernatant of Vero E6 and Huh7 cells, as well as HEK293T cells expressing human angiotensin-converting enzyme 2 (ACE2), infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It also reduces lung RNA copy numbers and viral pneumonia in ACE2 transgenic mice infected with SARS-CoV-2 when administered at a dose of 0.1 mg/kg.

Chemical Properties

white to off-white powder

Uses

Bafilomycin A1 is a member of a potent family of macrocyclic lactones with broad spectrum biological activity, including activity against bacteria, yeast, fungi, nematodes, insects and tumour cell lines. Bafilomycin A1 is an inhibitor of vacuolar-type ATPase.

Uses

A macrolide antibiotic and potent and selective inhibitor of vacuolar-type (v-type) H+ ATPase

Uses

Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases.It is used as an antibacterial, antifungal, antineoplastic and an immunosuppressive. It prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes and is a macrolide antibiotic and potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase).

Definition

ChEBI: The most used of the bafilomycins, a family of toxic macrolide antibiotics derived from Streptomyces griseus.

General Description

A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay. Reported to selectively inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). The InSolution format with a purity of ≥97% by HPLC in 90% DMSO is also available (Cat. No. 508409).

Biological Activity

Highly potent, selective inhibitor of vacuolar H + -ATPases (IC 50 = 500 pM as measured in chromaffin granule membranes). Selective over other ATP hydrolyzing enzymes such as F-ATPases, Ca 2+ -ATPases, Na + /K + -ATPases and plasma membrane H + -ATPases.

Biochem/physiol Actions

Bafilomycin A1 is a macrolide antibiotic. Bafilomycin A1 acts as a potent and selective inhibitor of vacuolar-type H+-ATPase.

storage

-20°C

References

1) Werner?et al.? (1984) Metabolic products of microorganisms. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity; J. Antibiot.,?37?110 2) Drose and Altendorf? (1997)?Bafilomycins and concanamycins as inhibitors of V-ATPase and P-ATPase;?J. Exp. Biol.,?200?1 3) Yamamoto?et al. (1998)?Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells;?Cell Struct. Func.,?23?33

BAFILOMYCIN A1 Preparation Products And Raw materials

Raw materials

Preparation Products

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BAFILOMYCIN A1 Suppliers

Australia 2 Belgium 1 China 154 France 1 Germany 4 India 1 Japan 3 Poland 1 South Korea 1 Switzerland 2 United Kingdom 10 United States 32 USA 1 Global 213
Shanghai Aitixi Biotechnology Co., Ltd
Tel
18721763493 18721763493
Email
2493172863@qq.com
Country
China
ProdList
1009
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58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 13675144456
Fax
025-85563444
Email
sean.lv@synzest.com
Country
China
ProdList
11438
Advantage
58
Xianning Shen Lan Biomedical Research and Development Co., Ltd.
Tel
18171815831
Email
1341138380@qq.com
Country
China
ProdList
3577
Advantage
58
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Hefei fuya biotechnology co. LTD
Tel
18096409024
Email
sales02@foreversyn.com
Country
China
ProdList
1904
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4727
Advantage
58
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View Lastest Price from BAFILOMYCIN A1 manufacturers

Dideu Industries Group Limited
Product
BAFILOMYCIN A1 88899-55-2
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-16
Career Henan Chemical Co
Product
BAFILOMYCIN A1 88899-55-2
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-24

88899-55-2, BAFILOMYCIN A1Related Search:

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  • (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-((1S,2R,3S)-2-hydroxy-1-methyl-3-((2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5
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  • (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
  • (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-Methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-Methyl-6-(1-Methylethyl)-2H-pyran-2-yl]butyl]-3,15-diMethoxy-5,7,9,11-tetraMethyloxacyclohexadeca-3,5,11,13-tetraen-2-o
  • Oxacyclohexadeca-3,5,11,13-tetraen-2-one, 8-hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-, (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-
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  • BAFILOMYCIN A1 USP/EP/BP
  • (3Z,5Z,7R,8S,9S,11E,13E,15S,16R)-16-((2S,3R,4S)-4-((2R,4R,5S,6R)-2,4-Dihydroxy-6-isopropyl-5-methyltetrahydro-2H-pyran-2-yl)-3-hydroxypentan-2-yl)-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
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  • (3Z,5E,11E,13E)-16-[4-(2,4-dihydroxy-5-methyl-6-propan-2-yloxan-2-yl)-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one
  • 88899-55-2
  • C35H58O9
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